iNew MedicineOver the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide.
Wenjun Zhen +6 more
doaj +2 more sources
Kcna3 Deficiency Promotes Renin-Associated Hypertension Through Ca2+-Dependent AKT–PKA–CREB Signaling [PDF]
BiomoleculesHypertension is an important risk factor for cardiovascular and renal diseases, yet the mechanisms linking ion channel dysfunction to hypertension remain poorly understood.
Ye Wang +9 more
doaj +2 more sources
Insight Into the Mechanism of Cytotoxicity of Membrane-Permeant Psoralenic Kv1.3 Channel Inhibitors by Chemical Dissection of a Novel Member of the Family [PDF]
Redox Biology, 2020 Mario Zoratti +2 more
exaly +2 more sources
Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. [PDF]
PLoS ONE, 2013 Diphenyl phosphine oxide-1 (DPO-1) is a potent Kv1.5 channel inhibitor that has therapeutic potential for the treatment of atrial fibrillation. Many other Kv1.5 channel blockers also potently inhibit the Kv1.3 channel, but whether DPO-1 blocks Kv1.3 ...
Ning Zhao +5 more
doaj +1 more source
Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel. [PDF]
Sci Rep, 2016 AbstractThe potassium channel Kv 1.3 plays a vital part in the activation of T lymphocytes and is an attractive pharmacological target for autoimmune diseases. BmP02, a 28-residue peptide isolated from Chinese scorpion (Buthus martensi Karsch) venom, is a potent and selective Kv1.3 channel blocker.
Wu B, Wu BF, Feng YJ, Tao J, Ji YH.
europepmc +3 more sources
The Kv1.3 channel: Functional consequences of cellular and spatial reorganization [PDF]
[eng] The voltage-gated potassium channel Kv1.3 is a transmembrane protein that facilitates the selective flow of K+ ions across cell membranes, playing a crucial role in regulating cellular excitability and maintaining the electrochemical gradient. This
Navarro Pérez, María
core +5 more sources
Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
Nature Communications, 2022 The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune responses. Here, the authors report structures of the Kv1.3 potassium channel with and without immunoglobulin modulators, shedding light on the ...
Purushotham Selvakumar +10 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. IL-17 level is significantly increased in inflammatory conditions of the CNS, including but not limited to post-stroke and multiple sclerosis.
Han Liu +7 more
doaj +1 more source
Kv1.3: a multifunctional channel with many pathological implications [PDF]
Expert Opinion on Therapeutic Targets, 2017 Ion channels are transmembrane proteins that form aqueous pores driving ions through the plasma membrane in favor of an electrochemical gradient.
Antonio, Serrano-Albarrás +4 more
openaire +2 more sources
Role of Kv1.3 Channels in Platelet Functions and Thrombus Formation [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020 Objective: Platelet activation by stimulatory factors leads to an increase in intracellular calcium concentration ([Ca 2+ ] i ), which is essential for almost all platelet functions. Modulation of Ca 2+ influx and [Ca
Cheng Fan +8 more
openaire +2 more sources