Results 51 to 60 of about 1,258,603 (180)

Biophysical Characterization and Expression Analysis of Kv1.3 Potassium Channel in Primary Human Leukemic B Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Pharmacological inhibition of the potassium channel Kv1.3 has been shown to selectively kill B cells from patients with chronic lymphocytic leukemia (B-CLL).
Ildiko Szabo, Livio Trentin, Valentina Trimarco, Gianpietro Semenzato, Luigi Leanza   +4 more
doaj   +1 more source

Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2019
Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage ...
Isadora S Oliveira, Isabela G Ferreira, Gabriel M Alexandre-Silva, Felipe A Cerni, Caroline M Cremonez, Eliane C Arantes, Umberto Zottich, Manuela B Pucca   +7 more
openaire   +5 more sources

Commentary on 'Immler et al. (2021) The voltage‑gated potassium channel Kv1.3 regulates neutrophil recruitment during inflammation' Cardiovasc Res 2021 (doi:10.1093/cvr/cvab133) : Roll over—Kv1.3 ! The function of a voltage-gated potassium channel in leucocytes revealed

, 2021
Roll over - Kv1.3!
Roeper, Jochen, Jochen Roeper
core   +1 more source

Characterization of the role of Kv1.3 Potassium channel in Macrophages and regulatory T lymphocytes

, 2023
reservedSeveral evidences have documented a close relationship between ion channels and cancer, supporting a pivotal role for Potassium channels in cancer therapy.
BONETTO, VITTORIA
core  

Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug [PDF]

, 2022
We report two structures of the human voltage-gated potassium channel (Kv) Kv1.3 in immune cells alone (apo-Kv1.3) and bound to an immunomodulatory drug called dalazatide (dalazatide–Kv1.3).
Vorobyov, Igor, Tyagi, A., Ahmed, T., Jian, Shi, Goay, S., Bajaj, Saumya, Bhushan, S., Zhao, Y., Bhushan, Shashi, Zhao, Yue, Ahmed, Tofayel, Tian, Changlin, Chandy, K George, Goay, Stephanie Shee Min, Jian, S., Ong, S., Vorobyov, I., Bajaj, S., Tian, C., Chandy, K., Tyagi, Anu, Ong, Seow Theng, Chandy, K. George, Shi Jian, Saumya Bajaj, Yue Zhao, K. George Chandy, Stephanie Shee Min Goay, Tofayel Ahmed, Changlin Tian, Anu Tyagi, Shashi Bhushan, Seow Theng Ong, Igor Vorobyov   +33 more
core   +1 more source

The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression [PDF]

Drug Development Research, 2011
AbstractThe voltage‐gated Kv1.3 and the calcium‐activated KCa3.1 potassium channel modulate many calcium‐dependent cellular processes in immune cells, including T‐cell activation and proliferation and have therefore been proposed as novel therapeutic targets for immunomodulation.
Jenny, Lam, Heike, Wulff
openaire   +2 more sources

Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma

Cancers, 2022
Despite several new developments in the treatment of multiple myeloma, all available therapies are only palliative without curative potential and all patients ultimately relapse. Thus, novel therapeutic options are urgently required to prolong survival of or to even cure myeloma.
Stephanie Kadow, Fabian Schumacher, Melanie Kramer, Gabriele Hessler, René Scholtysik, Sara Oubari, Patricia Johansson, Andreas Hüttmann, Hans Christian Reinhardt, Burkhard Kleuser, Mario Zoratti, Andrea Mattarei, Ildiko Szabò, Erich Gulbins, Alexander Carpinteiro   +14 more
openaire   +4 more sources

Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K+ current conducted by KV1.3

Neurobiology of Disease, 2017
Brain white matter damage is frequently detected in patients infected with human immunodeficiency virus type 1 (HIV-1). White matter is composed of neuronal axons sheathed by oligodendrocytes (Ols), the myelin-forming cells in central nervous system. Ols
Han Liu, Jianuo Liu, Enquan Xu, Guihua Tu, Minglei Guo, Shangdong Liang, Huangui Xiong   +6 more
doaj   +1 more source

ROLE OF KV1.3 CHANNELS IN INTIMAL HYPERPLASIA

Journal of the American College of Cardiology, 2012
Resumen del poster presentado al American College of Cardiology - 61st Annual Scientific Seesion & Expo celebrado en Chicago (US) del 24 al 27 de marzo de 2012.
Novensa, Mercè Roquè. Laura, Cidad, Pilar, Batlle, Montserrat, Miguel-Velado, Eduardo, Alonso, Esperanza, Pérez-García, Teresa, López, José Ramón, Heras, Magda   +7 more
openaire   +1 more source

KCNE4 Is an Inhibitory Subunit to Kv1.1 and Kv1.3 Potassium Channels [PDF]

Biophysical Journal, 2003
Kv1 potassium channels are widely distributed in mammalian tissues and are involved in a variety of functions from controlling the firing rate of neurons to maturation of T-lymphocytes. Here we show that the newly described KCNE4 beta-subunit has a drastic inhibitory effect on currents generated by Kv1.1 and Kv1.3 potassium channels.
Grunnet, Morten, Rasmussen, Hannne B, Hay-Schmidt, Anders, Rosenstierne, Maiken, Klaerke, Dan A, Olesen, Søren-Peter, Jespersen, Thomas   +6 more
openaire   +2 more sources