Results 71 to 80 of about 1,258,603 (180)

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers. [PDF]

PLoS ONE, 2017
Kv1.3 is a voltage-gated potassium channel expressed on T cells that plays an important role in T cell activation. Previous studies have shown that blocking Kv1.3 channels in human T cells during activation results in reduced calcium entry, cytokine ...
Wai-Ping Fung-Leung, Wilson Edwards, Yi Liu, Karen Ngo, Julianty Angsana, Glenda Castro, Nancy Wu, Xuejun Liu, Ronald V Swanson, Alan D Wickenden   +9 more
doaj   +1 more source

Venom‐Derived Bioactive Peptides: From Toxins to Therapeutics

Advanced Therapeutics, Volume 9, Issue 8, August 2026.
Venomics → Target Identification → Peptide Optimization → Therapeutic Translation Bioactive venom peptides targeting ion channels, enzymes, and receptors drive the development of next‐generation precision therapeutics. ABSTRACT Venoms are complex biochemical mixtures composed of diverse bioactive components, including proteins, enzymes, small molecules,
Eldho Sabu, Othman Al Musaimi
wiley   +1 more source

Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease

, 2020
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of these targets can provide potential treatments to halt disease ...
Harischandra, Dilshan, Kanthasamy, Anumantha G, Malovic, Emir, Ay, Muhammet, Palanisamy, Bharathi N, Jin, Huajun, Abdalla, Ahmed, Charli, Adhithiya, Rangaraju, Srikant, Singh, Neeraj, Gabrielle, Michelle, Langley, Monica, Luo, Jie, Wulff, Heike, Anantharam, Vellareddy, Sarkar, Souvarish, Nguyen, Hai M, Anantharam, Poojya, Singh, Vikrant, Manne, Sireesha, Neal, Matthew, Jin, Lee-Way, Panicker, Nikhil, Rokad, Dharmin   +23 more
core   +1 more source

Microglia Kv1.3 Channels Contribute to Their Ability to Kill Neurons [PDF]

The Journal of Neuroscience, 2005
Many CNS disorders involve an inflammatory response that is orchestrated by cells of the innate immune system: macrophages, neutrophils, and microglia (the endogenous CNS immune cell). Hence, there is considerable interest in anti-inflammatory strategies that target these cells.
Christopher B, Fordyce, Ravi, Jagasia, Xiaoping, Zhu, Lyanne C, Schlichter   +3 more
openaire   +2 more sources

New Screening System for Selective Blockers of Voltage-Gated K+ Channels Using Recombinant Cell Lines Dying Upon Single Action Potential

Journal of Pharmacological Sciences, 2013
To develop a simple screening system for blockers of voltage-gated Kv1.3 and Kv1.5 channels, new cell lines co-expressing mutated Nav1.5 (IFM/Q3), Kir2.1 (Kir), and Kv1.3 or Kv1.5 were introduced as IFM/Q3+Kir+Kv1.3 and IFM/Q3+Kir+Kv1.5, respectively ...
Masato Fujii, Keisuke Hayashi, Susumu Ohya, Hisao Yamamura, Yuji Imaizumi   +4 more
doaj   +1 more source

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway [PDF]

Kv1.3 is a multifunctional potassium channel implicated in multiple pathologies, including cancer. However, how it is involved in disease progression is not fully clear.
Bachmann M., Checchetto V., Varanita T., Bonesso D., Leanza L., Gulbins E., Romualdi C., Szabo I., Doni D., Carpanese V., Prosdocimi E., Peruzzo R., Carrer A., Rettel M., Felipe A., Perez-Verdaguer M., Muccioli S., Velle A., Festa M., Todesca L. M., Costantini P., Cendron L., Stein F., Edwards M. J.   +23 more
core   +1 more source

N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3 [PDF]

, 2015
The voltage-gated potassium channel Kv1.3 is an important target for the treatment of autoimmune diseases and asthma. Blockade of Kv1.3 by the sea anemone peptide K+-channel toxin from Stichodactyla helianthus (ShK) inhibits the proliferation of effector
Pennington, Michael W, Huq, Redwan, Beeton, Christine, Chhabra, Sandeep, Norton, Raymond S, Chang, Shih C, Smith, Brian J   +6 more
core   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Christopher M. Fanger, Khoury, Rosana M, Negulescu, Paul A, Cahalan, Michael D, Neben, Amber L, Hubert H. Kerschbaum, Fanger, Christopher M, Rosana M. Khoury, Kerschbaum, Hubert H, Claudia Eder, Amber L. Neben, George R. Ehring, Eder, Claudia, Michael D. Cahalan, Paul A. Negulescu, Ehring, George R, Negulescu, PA, Fanger, CM, Kerschbaum, HH, Khoury, RM, Ehring, GR, Eder, C, Cahalan, MD, Neben, AL   +23 more
core   +1 more source

A novel potassium channel in lymphocyte mitochondria [PDF]

, 2005
The margatoxin-sensitive Kv1.3 is the major potassium channel in the plasma membrane of T lymphocytes. Electron microscopy, patch clamp, and immunological studies identified the potassium channel Kv1.3, thought to be localized exclusively in the cell ...
J. , JEKLE, C. , LANG, M. , GULBINS, SZABO', ILDIKO', M. , ADAMS, E., I. , BOCK, A. , SODDEMANN, F. , ZORATTI, Szabò I, Adams C, Zoratti M, Lang F, Jeckle A, Gulbins E, Bock J, Soddeman M   +16 more
core   +1 more source