Results 81 to 90 of about 1,258,603 (180)

Molecular Determinants of Selectivity for Kv1.3 K+ Channels [PDF]

Biophysical Journal, 2013
The voltage-gated Kv1.3 potassium channel plays a key role in the activation of T lymphocytes by maintaining a negative membrane potential. By blocking these channels the proliferation of T cells can be inhibited. Anuroctoxin (AnTX), a 35-amino-acid peptide isolated and characterized previously from the venom of the scorpion Anuroctonus phaiodactylus ...
Bartok, Adam, Panyi, Gyorgy, Domingos Possani, Lourival, Varga, Zoltan   +3 more
openaire   +1 more source

Bioelectrical Interfaces Beyond Excitable Cells: Cancer, Aging, and Gene Expression Modulation

Advanced Materials Interfaces, Volume 13, Issue 10, 19 May 2026.
ABSTRACT The investigation of biological conductivity has evolved from its classical foundation based on ionic fluxes underpinning cardiac and neuronal excitability to a multifaceted regulator of cellular physiology. Traditional approaches for probing electrical events in living matter focused largely on action potentials recording.
Paolo Cadinu, Matthew K. Burgess, Catarina Franco Jones, Marzia Iarossi, Manuel Schröter, Nako Nakatsuka, Mustafa B. A. Djamgoz, Gil Gonçalves, Sidahmed Abayzeed, Paola Sanjuán‐Alberte, Paula M. Mendes, Frankie J. Rawson, Malavika Nair, Michael Levin, Rosalia Moreddu   +14 more
wiley   +1 more source

Cancer: A bioelectric disease?

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
The membrane potential (Vm) has emerged as a systems‐level regulator of cancer cell behaviour, linking ion channel activity to processes such as proliferation, differentiation and therapeutic response. This framework provides a roadmap for translating Vm measurement and validation into bioelectric precision medicine, integrating multi‐omics and ...
Celine Desoyer, Roko Šupe, Sahar Ghorbanpour, Debkalpa Goswami, Mina Khalaj, Nazanin Karami, Dagmar Brislinger, Charlotte A. E. Hauser, Christian Baumgartner   +8 more
wiley   +1 more source

Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley   +1 more source

Kv1.3 channels in mitochondria: A key coupling in cellular proliferation? [PDF]

, 2019
The Kv1.3 channel increases cellular proliferation and migration in multiple cell types. Various mechanisms have been proposed to explain how the channel stimulates proliferation, but the topic remains controversial.
Styles, Faye Louise
core   +4 more sources

Lack of Structural Change in Olfactory Circuitry Following Fecal Microbiome Transplant From Donors Subjected to Diet‐induced Obesity

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Fecal microbiome transplant from obese donor mice evokes microbiota changes that are not sufficient to change olfactory synaptic structure or glucose sensitivity in control‐fat (CF) fed recipient mice. FMT CF, fecal microbiome transplantation from control‐fat (CF) fed donors; FMT MHF, fecal microbiome transplantation from moderately high‐fat (MHF) fed ...
Ashley M. Loeven, Franklin A. Pacheco, Amber N. Brown, Debra Ann Fadool   +3 more
wiley   +1 more source

Towards a digital cancer cell twin: External pharmacological validation of a mechanistic A549 electrophysiology model

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
A mechanistic in‐silico model of A549 lung adenocarcinoma electrophysiology reproduces drug‐modulated ion‐channel responses across wild‐type and erlotinib‐resistant phenotypes. By accurately capturing KCa1.1 and KCa3.1 inhibition and phenotype‐specific KCa remodelling within biologically plausible bounds, the model provides a validated foundation for ...
Celine Desoyer, Martin Ruf, Christian Baumgartner   +2 more
wiley   +1 more source

Models of cardiomyocyte–non‐myocyte electrical interactions

The Journal of Physiology, Volume 604, Issue 4, Page 1607-1628, 15 February 2026.
Abstract figure legend Cardiomyocyte–non‐myocyte (CM–NM) electrotonic coupling. Left: conceptual contact‐based interactions between CM and other NM via connexin (Cx) proteins. Three basic scenarios are proposed: (i) ‘zero‐sided coupling’ where there are no electrical connections between CM and NM, (ii) ‘single‐sided coupling’ where NM are connected to ...
Ana Simon‐Chica, Axel Loewe, Peter Kohl   +2 more
wiley   +1 more source

The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer [PDF]

Frontiers in Physiology, 2013
Voltage-dependent K(+) channels (Kv) are involved in a number of physiological processes, including immunomodulation, cell volume regulation, apoptosis as well as differentiation. Some Kv channels participate in the proliferation and migration of normal and tumor cells, contributing to metastasis. Altered expression of Kv1.3 and Kv1.5 channels has been
Comes i Beltrán, Núria, Bielanska, Joanna, Vallejo Gracia, Albert, Serrano-Albarrás, Antonio, Marruecos, Laura, Gómez Fernández, Diana Lucía, Soler Prat, Concepció, Condom i Mundó, Enric, Ramón y Cajal Agüeras, Santiago, Hernández Losa, Javier, Ferreres, Joan C., Felipe Campo, Antonio   +11 more
openaire   +4 more sources

Silencing of SLC6A1 Enhanced Cell Apoptosis in Prostate Cancer Through a Mitochondrial Mechanism

Advances in Urology, Volume 2026, Issue 1, 2026.
Objective The present study aims to elucidate the molecular mechanisms underlying the association between solute carrier family 6 member 1 (SLC6A1) and the aggressive progression of prostate cancer, with a particular emphasis on its relationship with mitochondrial function.
Chaojiang Chen, Ranting Wang, Zhuoyuan Lin, Jianxin Li, Yu Zheng, Kostis Gyftopoulos   +5 more
wiley   +1 more source