Results 101 to 110 of about 1,258,603 (180)
Role of Kv1.3 Potassium Channels in Auditory Function
Biophysical Journal, 2014 Kv1.3 is a low threshold voltage-dependent potassium channel involved in various physiological functions. Within the central nervous system, deletion of Kv1.3 gene from mitral cells of the olfactory bulb dramatically increased the sensitivity of the olfactory system. We have recently shown that Kv1.3 channels are present in presynaptic terminals of the
El-Hassar, Lynda +5 more
openaire +1 more source
Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease
Neurobiology of Disease, 2010 In Alzheimer's disease (AD), potassium channel abnormalities have been reported in both neural and peripheral tissues. Herein, using whole-cell patch-clamp, we demonstrate an aberrant glutamate-dependent modulation of KV1.3 channels in T lymphocytes of ...
Cornelia Poulopoulou +6 more
doaj +1 more source
Role for Kv1.3 channels in sympathetic neurovascular transmission
The FASEB Journal, 2009 We tested the hypothesis that Kv1.3 channels affect sympathetic neurovascular transmission using margatoxin (MgTX), a specific inhibitor. In isolated rat tail arteries during electrical field stimulation (4 Hz, 60 volts, 1 min) MgTX (10 nM) decreased release of 3
Deborah H. Damon +3 more
openaire +1 more source
Modeling the Binding of Three Toxins to the Voltage-Gated Potassium Channel (Kv1.3)
, 2011 The conduction properties of the voltage-gated potassium channel Kv1.3 and its modes of interaction with several polypeptide venoms are examined using Brownian dynamics simulations and molecular dynamics calculations.
Chen, Rong +7 more
core +1 more source
Up-Regulation of Voltage Gated K+ Channels Kv1.3 and Kv1.5 by Protein Kinase PKB/Akt
Cellular Physiology and Biochemistry, 2015 Background: The voltage gated K+ channels Kv1.3 and Kv1.5 contribute to the orchestration of cell proliferation. Kinases participating in the regulation of cell proliferation include protein kinase B (PKB/Akt). The present study thus explored whether PKB/
Jamshed Warsi +4 more
doaj +1 more source
, 2016 A polypeptide toxin extracted from scorpion venom, OSK1, is modified such that its potency is drastically enhanced in blocking one class of voltage-gated potassium channels, Kv1.3, which is a pharmacological target for immunosuppressive therapy.
Rong Chen (29176) +1 more
core +1 more source
Protein kinase-dependent Kv1.3 biology [PDF]
, 2023 [eng] The voltage gated potassium channel Kv1.3 is a transmembrane protein that selectively drives potassium ions participating in the electrochemical gradient of cell membranes.
Estadella Pérez, Irene
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reservedKv1.3, a member of the Shaker Kv1 channel family, has wide expression in excitable and non-excitable cells and it is involved in different physiological processes. Aberrant expression of Kv1.3 has also been correlated to many pathological states,
PUTNIK, MILENA
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A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis. [PDF]
Proc Natl Acad Sci U S A, 2023 Wang Y +7 more
europepmc +1 more source
Cytotoxıc effect of KV1.3 potassium channel blocker clofazimine on hematological cancer cell lines
, 2015 Introduction / Aim: Potassium ion channels play an important role in regulating cell proliferation by maintenance of the membrane potential and subsequent Ca2+ signaling.
Ipek, Durusu +3 more
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