Results 121 to 130 of about 1,258,603 (180)

Early-stage Determinants of T1–S1 Conformations in Kv1.3 Channels

Journal of Molecular Biology
ABSTRACT Early-stage biogenesis of voltage-gated potassium channels (Kv) remains remarkably understudied yet is key to defining co- and post-translational acquisition of Kv secondary, tertiary, and quaternary conformations. Thus, we have studied nascent folding events and their determinants in Kv1.3, a tetrameric ion channel highly ...
Liwei Tu, Aaron Sykes, Therese Davis, Sophia Gross, Carol Deutsch   +4 more
openaire   +2 more sources

Kv1.3 Channel Inhibition Limits Uremia-Induced Calcification in Mouse and Human Vascular Smooth Muscle. [PDF]

Function (Oxf), 2021
Cazaña-Pérez V, Cidad P, Navarro-González JF, Rojo-Mencía J, Jaisser F, López-López JR, Alvarez de la Rosa D, Giraldez T, Pérez-García MT.   +8 more
europepmc   +1 more source

Pharmacological inhibition of Kv1.3 channel reduces sevoflurane-induced cognitive impairment through NLRP3-dependent microglial modulation

Brain Research Bulletin
Sevoflurane anesthesia is frequently linked to cognitive dysfunction in elderly individuals, with neuroinflammation, particularly microglial activation, playing a critical role in this pathology.
Bowen Li, Ying Gao, Huiyue Han, Zhu Wang, Yang Zhang, Li Yu, Yunzhi Ling   +6 more
doaj   +1 more source

Potassium channel Kv1.3 (KCNA3) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Corrigendum to "Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family" [Redox Biol. 37 (2020 Sep 6) 101705-101721]. [PDF]

Redox Biol, 2021
Peruzzo R, Mattarei A, Azzolini M, Becker-Flegler KA, Romio M, Rigoni G, Carrer A, Biasutto L, Parrasia S, Kadow S, Managò A, Urbani A, Rossa A, Semenzato G, Soriano ME, Trentin L, Ahmad S, Edwards M, Gulbins E, Paradisi C, Zoratti M, Leanza L, Szabò I.   +22 more
europepmc   +1 more source

Piezo1 agonists are potent off-target inhibitors of the Kv1.3 channel via gating modification. [PDF]

Mol Pharmacol
Huang K, Shim H, Wulff H, Nguyen HM.
europepmc   +1 more source

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function. [PDF]

J Gen Physiol
Colomer-Molera M, Sastre D, Felipe A.
europepmc   +1 more source

β1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells. [PDF]

J Clin Invest, 2020
Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, Zipp F, Bittner S.   +12 more
europepmc   +1 more source

Kv1.3 Channel inhibition by nanoformulated MeuKTx as a therapeutic strategy in breast cancer. [PDF]

Sci Rep
Kazemi-Lomedasht F, Eftekhari Z, Safarpour H.   +2 more
europepmc   +1 more source

Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer's Disease: Possible Therapeutic Role of K_V1.3 Channel Blockade. [PDF]

Front Cell Neurosci, 2022
Revuelta M, Urrutia J, Villarroel A, Casis O.   +3 more
europepmc   +1 more source