Results 141 to 150 of about 1,258,603 (180)

Scorpion venom peptides: Novel therapeutic approaches for inflammatory and hepatic disorders. [PDF]

ILIVER
Doctor J, Parikh Z, Chauhan A, Raina A.
europepmc   +1 more source

Selective Kv1.3 inhibition promotes M2 microglial polarization, accelerates hematoma resolution, and improves neurological recovery following collagenase-induced spontaneous intracerebral hemorrhage in mice. [PDF]

Vet World
Saleeon W, Vattarakorn A, Thongta N, Boondam Y, Wanasuntronwong A, Watanapa WB, Tapechum S, Pakaprot N.   +7 more
europepmc   +1 more source

A designer pore-blocking peptide reveals an electrostatic complementation mechanism for the inhibition-resistant Kv1.5 channel. [PDF]

Sci Adv
Zhao R, Nayak M, Shen R, Dai H, Hua P, Perozo E, Goldstein SAN.   +6 more
europepmc   +1 more source

Comparative Interactome Analysis Reveals Architectural Principles Governing K⁺ Channel Function in Cancer. [PDF]

Int J Mol Sci
Sadeghi S, Capera J, Battistello G, Carpanese V, Felipe A, Szabò I, Checchetto V.   +6 more
europepmc   +1 more source

Comparison of the anti-inflammatory effects of esomeprazole and fexuprazan in lipopolysaccharide-stimulated RAW 264.7 macrophages. [PDF]

BMC Pharmacol Toxicol
Ju GB, Kim SJ, Lee D, Kim MJ, Ko WK, Cho MJ, Sohn S.   +6 more
europepmc   +1 more source

The Secret Life of Ion Channels: Kv1.3 Potassium Channels and Proliferation

American Journal of Physiology - Cell Physiology, 2018
Kv1.3 channels are involved in the switch to proliferation of normally quiescent cells, being implicated in the control of cell cycle in many different cell types and in many different ways. They modulate membrane potential controlling K+ fluxes, sense changes in potential, and interact with many signaling molecules through their intracellular domains.
Maria Teresa Pérez-García, José Ramón López López, Pilar Cidad   +2 more
exaly   +4 more sources

Molecular Determinants of Kv1.3 Potassium Channels-Induced Proliferation [PDF]

Journal of Biological Chemistry, 2016
Changes in voltage-dependent potassium channels (Kv channels) associate to proliferation in many cell types, including transfected HEK293 cells. In this system Kv1.5 overexpression decreases proliferation, whereas Kv1.3 expression increases it independently of K(+) fluxes.
Inés Alvarez-Miguel, Maria Teresa Pérez-García, José Ramón López López   +2 more
exaly   +5 more sources

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Open channel block of Kv1.3 by rosiglitazone and troglitazone: Kv1.3 as the pharmacological target for rosiglitazone

Naunyn-Schmiedeberg's Archives of Pharmacology, 2006
The effects of rosiglitazone and troglitazone were examined on cloned Kv1.3 channels stably expressed in Chinese hamster ovary cells using the whole-cell configuration of the patch-clamp technique. Rosiglitazone decreased the Kv1.3 currents and accelerated the decay rate of current inactivation in a concentration-dependent manner with an IC(50) of 18.6
Hye Sook, Ahn, Sung Eun, Kim, Hyun-Jong, Jang, Myung-Jun, Kim, Duck-Joo, Rhie, Shin-Hee, Yoon, Yang-Hyeok, Jo, Myung-Suk, Kim, Ki-Wug, Sung, Seong Yun, Kim, Sang June, Hahn   +10 more
openaire   +2 more sources

Benzamide derivatives as blockers of Kv1.3 ion channel

Bioorganic & Medicinal Chemistry Letters, 2003
The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of immune responses in vivo. A class of benzamide Kv1.3 channel inhibitors has been identified.
Shouwu, Miao, Jianming, Bao, Maria L, Garcia, Joung L, Goulet, Xingfang J, Hong, Gregory J, Kaczorowski, Frank, Kayser, Gloria C, Koo, Andrew, Kotliar, William A, Schmalhofer, Kashmira, Shah, Peter J, Sinclair, Robert S, Slaughter, Marty S, Springer, Mary Jo, Staruch, Nancy N, Tsou, Frederick, Wong, William H, Parsons, Kathleen M, Rupprecht   +18 more
openaire   +2 more sources

Kv1.3 potassium channels in human alveolar macrophages

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2003
Human alveolar macrophages were obtained from macroscopically normal lung tissue obtained at surgical resections, isolated by adherence, and identified by morphology. Whole cell recordings were made from cells 1-3 h in culture, using electrodes containing potassium chloride.
Mackenzie, Amanda B., Chirakkal, Hari, North, R. Alan   +2 more
openaire   +3 more sources