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Native Kv1.3 Channels are Upregulated by Protein Kinase C
Journal of Membrane Biology, 1997The voltage-gated potassium channel, Kv1.3, which is highly expressed in a number of immune cells, contains concensus sites for phosphorylation by protein kinase C (PKC). In lymphocytes, this channel is involved in proliferation-through effects on membrane potential, Ca2+ signalling, and interleukin-2 secretion-and in cytotoxic killing and volume ...
I, Chung, L C, Schlichter
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Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants
Bioorganic & Medicinal Chemistry Letters, 2009New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.
Stefano, Pegoraro +11 more
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Up-regulation of Kv1.3 Channels by Janus Kinase 2
The Journal of Membrane Biology, 2015The janus-activated kinase 2 JAK2 participates in the signalling of several hormones including interferon, a powerful regulator of lymphocyte function. Lymphocyte activity and survival depend on the activity of the voltage-gated K(+) channel KCNA3 (Kv1.3).
Hosseinzadeh, Zohreh +5 more
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Kv1.3 potassium channels as a therapeutic target in multiple sclerosis
Expert Opinion on Therapeutic Targets, 2009We discuss the potential use of inhibitors of Kv1.3 potassium channels in T lymphocytes as therapeutics for multiple sclerosis. Current treatment strategies target the immune system in a non-selective manner. The resulting general immunosuppression, toxic side-effects and increased risk of opportunistic infections create the need for more selective ...
Srikant, Rangaraju +3 more
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Induction of Apoptosis in Macrophages via Kv1.3 and Kv1.5 Potassium Channels
Current Medicinal Chemistry, 2012We have previously shown that the mitochondrial potassium channel Kv1.3 (mtKv1.3) in T lymphocytes is a novel target of Bax. Mutation of Bax at lysine 128 (BaxK128E) abrogates its inhibitory effects on mtKv1.3 and prevents apoptosis. The importance of mtKv1.3 inhibition was underscored by the finding that membrane-permeant Kv1.3 inhibitors induced Bax ...
LEANZA, LUIGI +3 more
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Kv1.3 potassium channel blockade as an approach to insulin resistance
Expert Opinion on Therapeutic Targets, 2005Diabetes mellitus is a devastating metabolic disease caused by either insulin deficiency or resistance and characterised by abnormal glucose, protein and lipid metabolism. It affects > 150 million people worldwide, 14 million in the US alone (90% Type II and 10% Type I) where it accounts for approximately 15% of healthcare expenditure.
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Actinomycin D-induced apoptosis involves the potassium channel Kv1.3
Biochemical and Biophysical Research Communications, 2002Several cytostatic agents are known to induce apoptosis in T-leukemic cells. Although a variety of studies show the central role of apoptosis in cytostatic drug-induced cell death, many molecular details require definition. Here, we demonstrate that cells genetically deficient for the potassium channel Kv1.3 are resistant to apoptosis initiated by the ...
BOCK J. +3 more
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Role of KV1.3 channels in intimal hyperlasia
2015Peer ...
Roqué, Mercé +8 more
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Kv1.3 channel inhibition by indolic compounds
Biophysical Journal, 2022María Baena Nuevo +7 more
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