Results 111 to 120 of about 1,258,603 (180)

Molecular determinants for the endocytosis of the voltage-gated K(+) channel Kv1.3

The voltage-gated potassium channel Kv1.3 contributes to action potential conduction in sensory neurons and to sustained increases in cytoplasmic Ca(2+) that activate immune cells.
Dustin, Michael L., Estadella, Irene, Felipe, Antonio, Colomer-Molera, Magal\ued, Navarro-P\ue9rez, Mar\ueda, Sorkin, Alexander, Capera, Jesusa   +6 more
core   +1 more source

Pharmacological blockade of KV1.3 channel as a promising treatment in autoimmune diseases. [PDF]

J Transl Autoimmun, 2022
Cañas CA, Castaño-Valencia S, Castro-Herrera F.   +2 more
europepmc   +1 more source

Kv1.3 and Kv1.5 channels in leukocytes

, 2016
[eng] Voltage dependent potassium channels are a group of plasma membrane ion channels with a key role in the immune system as the predominant ion channels controlling the resting membrane potential and tuning intracellular Ca2+ signaling in lymphocytes, monocytes, macrophages, and dendritic cells.
openaire   +2 more sources

Potassium channel Kv1.3 (KCNA3) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources

Kv1.3 Channel, a Targetable Piece in the Complex Jigsaw Puzzle of Vascular Calcification? [PDF]

Function (Oxf), 2021
Gomez MF.
europepmc   +1 more source

Activation/inactivation of Tregs mediated by Kv1.3 potassium channels synergistically with exosome secretion to regulate myocardial fibrosis

Scientific Reports
Transforming growth factor-β (TGF-β) can promote myocardial fibrosis (MF). However, it was reported that regulatory T cells (Tregs) can reverse MF via secretion of anti-inflammatory cytokine IL-10.
Mengjia Li, Yang Wu, Yongzheng Zhang, Zihang Wang, Lufeng Cheng, Xiang Xie   +5 more
doaj   +1 more source

Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease. [PDF]

Proc Natl Acad Sci U S A, 2021
Ramesha S, Rayaprolu S, Bowen CA, Giver CR, Bitarafan S, Nguyen HM, Gao T, Chen MJ, Nwabueze N, Dammer EB, Engstrom AK, Xiao H, Pennati A, Seyfried NT, Katz DJ, Galipeau J, Wulff H, Waller EK, Wood LB, Levey AI, Rangaraju S.   +20 more
europepmc   +1 more source

The toxin mimic FS48 from the salivary gland of Xenopsylla cheopis functions as a Kv1.3 channel-blocking immunomodulator of T cell activation. [PDF]

J Biol Chem, 2022
Zeng Q, Lu W, Deng Z, Zhang B, Wu J, Chai J, Chen X, Xu X.   +7 more
europepmc   +1 more source

Kv1.3 Channel Blockade Improves Inflammatory Profile, Reduces Cardiac Electrical Remodeling, and Prevents Arrhythmia in Type 2 Diabetic Rats. [PDF]

Cardiovasc Drugs Ther, 2023
Zayas-Arrabal J, Alquiza A, Rodríguez-de-Yurre A, Echeazarra L, Fernández-López V, Gallego M, Casis O.   +6 more
europepmc   +1 more source

Investigation of the Cell Surface Topology and Pharmacology of the Human T Lymphocyte Kv1.3 Channel [PDF]

, 2005
Knowledge gathered about the voltage-gated K+ channel Kv1.3 in recent years indicates the essential role of this channel in T cell activation and the killing process of cytotoxic cells.
Bagdány, Miklós
core