Results 41 to 50 of about 1,258,603 (180)
HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity. [PDF]
PLoS ONE, 2013 Microglia plays a crucial role in the pathogenesis of HIV-1-associated neurocognitive disorders. Increasing evidence indicates the voltage-gated potassium (Kv) channels are involved in the regulation of microglia function, prompting us to hypothesize Kv ...
Jianuo Liu +6 more
doaj +1 more source
Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes [PDF]
, 2008 The potassium channel Kv1.3 has recently been located to the inner mitochondrial membrane of lymphocytes. Here, we show that mouse and human cells that are genetically deficient in either Kv1.3 or transfected with siRNA to suppress Kv1.3-expression ...
GULBINS E. +9 more
core +1 more source
Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells [PDF]
Neurosignals, 2017 Glioblastoma (GBM) is one of the most aggressive cancers, counting for a high number of the newly diagnosed patients with central nervous system (CNS) cancers in the United States and Europe. Major features of GBM include aggressive and invasive growth as well as a high resistance to treatment.
Venturini, Elisa +13 more
openaire +5 more sources
Calmodulin-dependent KCNE4 dimerization controls membrane targeting
Scientific Reports, 2021 The voltage-dependent potassium channel Kv1.3 participates in the immune response. Kv1.3 is essential in different cellular functions, such as proliferation, activation and apoptosis. Because aberrant expression of Kv1.3 is linked to autoimmune diseases,
Sara R. Roig +9 more
doaj +1 more source
Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes [PDF]
Journal of Biological Chemistry, 2003 Kv1.3 is a voltage-gated potassium channel with roles in human T cell activation/proliferation, cell-mediated cytotoxicity, and volume regulation and is thus a target for therapeutic control of T cell responses. Kv1.3 is also present in some mouse thymocyte subsets and splenocytes, but its role in the mouse is less well understood.
Pandelakis A, Koni +6 more
openaire +2 more sources
The Phosphorylation of Kv1.3: A Modulatory Mechanism for a Multifunctional Ion Channel
Cancers, 2023 The voltage-gated potassium channel Kv1.3 plays a pivotal role in a myriad of biological processes, including cell proliferation, differentiation, and apoptosis. Kv1.3 undergoes fine-tuned regulation, and its altered expression or function correlates with tumorigenesis and cancer progression.
María Navarro-Pérez +6 more
openaire +4 more sources
BMC Neuroscience, 2009 Background Neurotrophins are important regulators of growth and regeneration, and acutely, they can modulate the activity of voltage-gated ion channels.
Marks David R +4 more
doaj +1 more source
K+ Channels in Membrane Potential Dynamics and Migration of Neutrophil Granulocytes [PDF]
Arch Pharm (Weinheim)Neutrophil membrane potential dynamics regulate directed migration. Kir2.1 regulates neutrophil membrane potential and indirectly LTB4 secretion. Together with KCa3.1 and KV1.3, it is required for efficient chemotaxis. KCa3.1 and KV1.3 influence neutrophil migration without altering membrane potential, potentially through reduced LTB4 release (KCa3.1 ...
Ulu T +7 more
europepmc +2 more sources
Structural basis of the selective block of Kv1.2 by maurotoxin from computer simulations. [PDF]
PLoS ONE, 2012 The 34-residue polypeptide maurotoxin (MTx) isolated from scorpion venoms selectively inhibits the current of the voltage-gated potassium channel Kv1.2 by occluding the ion conduction pathway. Here using molecular dynamics simulation as a docking method,
Rong Chen, Shin-Ho Chung
doaj +1 more source
Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations
Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić +27 more
wiley +2 more sources