Results 21 to 30 of about 5,262 (204)
Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. [PDF]
PLoS ONE, 2013 Diphenyl phosphine oxide-1 (DPO-1) is a potent Kv1.5 channel inhibitor that has therapeutic potential for the treatment of atrial fibrillation. Many other Kv1.5 channel blockers also potently inhibit the Kv1.3 channel, but whether DPO-1 blocks Kv1.3 ...
Ning Zhao +5 more
doaj +1 more source
Voltage‐dependent conformational changes of Kv1.3 channels activate cell proliferation [PDF]
, 2020 The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation.
López López, José Ramón +6 more
core +2 more sources
Calmodulin-dependent KCNE4 dimerization controls membrane targeting
Scientific Reports, 2021 The voltage-dependent potassium channel Kv1.3 participates in the immune response. Kv1.3 is essential in different cellular functions, such as proliferation, activation and apoptosis. Because aberrant expression of Kv1.3 is linked to autoimmune diseases,
Sara R. Roig +9 more
doaj +1 more source
Multiple Binding Sites for Melatonin on Kv1.3 [PDF]
Biophysical Journal, 2001 Melatonin is a small amino acid derivative hormone of the pineal gland. Melatonin quickly and reversibly blocked Kv1.3 channels, the predominant voltage-gated potassium channel in human T-lymphocytes, acting from the extracellular side. The block did not show state or voltage dependence and was associated with an increased inactivation rate of the ...
Varga, Zoltán +6 more
openaire +2 more sources
Arteriosclerosis, Thrombosis, and Vascular Biology, 2010 Cellular proliferation requires an increase in expression and function of K+ channels.1–3 Blockade of K+ channels inhibits proliferation of many cell types,1,3 including vascular smooth muscle cells.2,4–7 Previous studies have shown growth factor-induced upregulation of KCa3.1 (sK4, IK1, locus KCNN4 ) in cultured smooth muscle cells; selective ...
openaire +1 more source
Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes [PDF]
, 2008 The potassium channel Kv1.3 has recently been located to the inner mitochondrial membrane of lymphocytes. Here, we show that mouse and human cells that are genetically deficient in either Kv1.3 or transfected with siRNA to suppress Kv1.3-expression ...
GULBINS E. +9 more
core +1 more source
Kv1.3: a potential pharmacological target for diabetes [PDF]
Acta Pharmacologica Sinica, 2010 K(+) channels, which are ubiquitous membrane proteins, play a central role in regulating the resting membrane potential and the shape and duration of the action potential in pancreatic beta-cells. There are at least three types of K(+) channels (K(ATP), K(Ca), and Kv2.1 channels) that are involved in glucose-stimulated insulin secretion in pancreatic ...
Bok Hee, Choi, Sang June, Hahn
openaire +2 more sources
Platelets, 2022 Kv1.3 is a voltage-gated K+-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution to platelet function is
Joy R Wright +7 more
doaj +1 more source
Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis
Frontiers in Pharmacology, 2021 Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation.
Ioannis Markakis +13 more
doaj +1 more source
Molecular determinants of the Kv1.3/KCNE4 interaction [PDF]
, 2022 [eng] Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4.
Sastre Martinez, Daniel
core +2 more sources