Results 31 to 40 of about 5,262 (204)

Mitochondrial ultrastructure and glucose signaling pathways attributed to the Kv1.3 ion channel

Frontiers in Physiology, 2016
Gene-targeted deletion of the potassium channel Kv1.3 (Kv1.3-/-) results in ‘Super-smeller’ mice with a sensory phenotype that includes an increased olfactory ability linked to changes in olfactory circuitry, increased abundance of olfactory cilia, and ...
Christopher P. Kovach, Dolly eAl Koborssy, Zhenbo eHuang, Brandon Michael Chelette, James Michael Fadool, Debra Ann Fadool   +5 more
doaj   +1 more source

Pleiotropic Effects of Simvastatin on the Regulation of Potassium Channels in Monocytes

Frontiers in Pharmacology, 2020
PurposeThe underlying mechanism of pleiotropic effects of statins on atherosclerosis is still unclear. Kv1.3 and KCa3.1 are two potassium channels that might be involved in monocyte migration and atherosclerosis formation.
Shaoping Wang, Yuhua Ran, Xuejun Chen, Chungang Li, Shujuan Cheng, Jinghua Liu   +5 more
doaj   +1 more source

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads

Channels, 2023
The voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactivating mutant of
K. George Chandy, Karoline Sanches, Raymond S. Norton   +2 more
doaj   +1 more source

Kv1.3 - EBV

, 2020
Kv1.3 raw data recordings on EBV ...
Alberto Montalbano
core   +1 more source

Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K+ current conducted by KV1.3

Neurobiology of Disease, 2017
Brain white matter damage is frequently detected in patients infected with human immunodeficiency virus type 1 (HIV-1). White matter is composed of neuronal axons sheathed by oligodendrocytes (Ols), the myelin-forming cells in central nervous system. Ols
Han Liu, Jianuo Liu, Enquan Xu, Guihua Tu, Minglei Guo, Shangdong Liang, Huangui Xiong   +6 more
doaj   +1 more source

Deciphering the Kv1.3/Caveolin Interaction [PDF]

Biophysical Journal, 2017
Lipid rafts are specialized membrane microdomains rich in sphingolipids and cholesterol where signaling molecules and their targets converge. These domains are more ordered and tightly packed than the surrounding bilayer. Rafts contain caveolins, which are implicated in many physiological processes such as cholesterol transport to the membrane surface.
Perez-Verdaguer, Mireia, Capera, Jesusa, Martinez-Marmol, Ramon, Camps, Marta, Comes, Nuria, Tamkun, Michael M., Felipe, Antonio   +6 more
openaire   +2 more sources

New Screening System for Selective Blockers of Voltage-Gated K+ Channels Using Recombinant Cell Lines Dying Upon Single Action Potential

Journal of Pharmacological Sciences, 2013
To develop a simple screening system for blockers of voltage-gated Kv1.3 and Kv1.5 channels, new cell lines co-expressing mutated Nav1.5 (IFM/Q3), Kir2.1 (Kir), and Kv1.3 or Kv1.5 were introduced as IFM/Q3+Kir+Kv1.3 and IFM/Q3+Kir+Kv1.5, respectively ...
Masato Fujii, Keisuke Hayashi, Susumu Ohya, Hisao Yamamura, Yuji Imaizumi   +4 more
doaj   +1 more source

The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane [PDF]

Scientific Reports, 2018
AbstractKv1.3 channels are expressed in several cell types including immune cells, such as T lymphocytes. The targeting of Kv1.3 to the plasma membrane is essential for T cell clonal expansion and assumed to be guided by the C-terminus of the channel.
Vörös, Orsolya, Szilágyi, Orsolya, Balajthy, András, Somodi, Sándor, Panyi, György, Hajdu, Péter   +5 more
openaire   +3 more sources

Temporal profiling of Kv1.3 channel expression in brain mononuclear phagocytes following ischemic stroke

Journal of Neuroinflammation, 2019
Background Microglia and CNS-infiltrating monocytes/macrophages (CNS-MPs) perform pro-inflammatory and protective anti-inflammatory functions following ischemic stroke.
Tianwen Gao, Syed Ali Raza, Supriya Ramesha, Ngozi V. Nwabueze, Amelia J. Tomkins, Lihong Cheng, Hailian Xiao, Manuel Yepes, Srikant Rangaraju   +8 more
doaj   +1 more source

Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein

Kidney & Blood Pressure Research, 2014
Background/Aims: Klotho, a protein mainly produced in the kidney and released into circulating blood, contributes to the negative regulation of 1,25(OH)2D3 formation and is thus a powerful regulator of mineral metabolism. As β-glucuronidase, alpha Klotho
Ahmad Almilaji, Sabina Honisch, Guilai Liu, Bernat Elvira, Sumant Singh Ajay, Zohreh Hosseinzadeh, Musaab Ahmed, Carlos Munoz, Mentor Sopjani, Florian Lang   +9 more
doaj   +1 more source