Results 51 to 60 of about 5,262 (204)
HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity. [PDF]
PLoS ONE, 2013 Microglia plays a crucial role in the pathogenesis of HIV-1-associated neurocognitive disorders. Increasing evidence indicates the voltage-gated potassium (Kv) channels are involved in the regulation of microglia function, prompting us to hypothesize Kv ...
Jianuo Liu +6 more
doaj +1 more source
Toxins, 2022 The voltage-gated potassium Kv1.3 channel is an essential component of vital cellular processes which is also involved in the pathogenesis of some autoimmune, neuroinflammatory and oncological diseases.
Nikita A. Orlov +6 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville +6 more
wiley +1 more source
Toxins, 2016 The Kv1.3 channel-acting scorpion toxins usually adopt the conserved anti-parallel β-sheet domain as the binding interface, but it remains challenging to discover some highly selective Kv1.3 channel-acting toxins.
Fang Ye +7 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen +6 more
wiley +1 more source
Acacetin Blocks Kv1.3 Channels and Inhibits Human T Cell Activation
Cellular Physiology and Biochemistry, 2014 Backgrounds/Aims: Acacetin, a natural flavonoid compound, has been proven to exert anti-inflammatory and immunomodulatory effects. Kv1.3 channels, highly expressed in human T cells, are attractive therapeutic targets to treat inflammatory and ...
Ning Zhao +6 more
doaj +1 more source
The effect of lentinan on the gene expression of major ion channels in T lymphocytes isolated from mice exposed to chronic radiation [PDF]
Nuclear Technology and Radiation Protection, 2013 It is known that Kv1.3, KCa3.1, CRAC, TRPM7, and Clswell are five important ion channels in T lymphocytes. To investigate the mechanism underlying the protective effects of lentinan against T lymphocytes injury induced by chronic radiation in mice, we
Fu Qing-Jie +7 more
doaj +1 more source
Venom‐Derived Bioactive Peptides: From Toxins to Therapeutics
Advanced Therapeutics, Volume 9, Issue 8, August 2026.Venomics → Target Identification → Peptide Optimization → Therapeutic Translation Bioactive venom peptides targeting ion channels, enzymes, and receptors drive the development of next‐generation precision therapeutics. ABSTRACT Venoms are complex biochemical mixtures composed of diverse bioactive components, including proteins, enzymes, small molecules,
Eldho Sabu, Othman Al Musaimi
wiley +1 more source
Purification, Visualization, and Biophysical Characterization of Kv1.3 Tetramers [PDF]
Journal of Biological Chemistry, 1997 The voltage-gated K+ channel of T-lymphocytes, Kv1.3, was heterologously expressed in African Green Monkey kidney cells (CV-1) using a vaccinia virus/T7 hybrid expression system; each infected cell exhibited 10(4) to 5 x 10(5) functional channels on the cell surface.
R H, Spencer +11 more
openaire +2 more sources
Potency of different Kv1.3 blockers on human Kv1.3 channels on transfected CHO cells.
, 2017 Potency of different Kv1.3 blockers on human Kv1.3 channels on transfected CHO cells.
Yi Liu (36759) +9 more
core +1 more source