Results 61 to 70 of about 5,262 (204)

Kv1.3 channels in mitochondria: A key coupling in cellular proliferation? [PDF]

, 2019
The Kv1.3 channel increases cellular proliferation and migration in multiple cell types. Various mechanisms have been proposed to explain how the channel stimulates proliferation, but the topic remains controversial.
Styles, Faye Louise
core   +4 more sources

Connexin 37 Regulates the Kv1.3 Pathway and Promotes the Development of Atherosclerosis

Mediators of Inflammation, 2022
Objective. To investigate the mechanism of Connexin 37 (Cx37) and Kv1.3 pathways in atherosclerosis (AS). Methods. ApoE-/- mice were given a high-fat diet to establish atherosclerosis (AS) model, and macrophages in mice were isolated and extracted to ...
Minqi Liao, Lihua Chen, Jiongbin Lu, Guangzhu Liang, Yongzhao Yao, Shumin Ouyang, Yanhua Yang, Zhengwei Jian, Suxia Guo   +8 more
doaj   +1 more source

Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels

Frontiers in Pharmacology, 2021
Loureirin B (LrB) is a constituent extracted from traditional Chinese medicine Resina Draconis. It has broad biological functions and an impressive immunosuppressive effect that has been supported by numerous studies.
Shujuan Shi, Qianru Zhao, Caihua Ke, Siru Long, Feng Zhang, Xu Zhang, Yi Li, Xinqiao Liu, Hongzhen Hu, Shijin Yin   +9 more
doaj   +1 more source

Fighting rheumatoid arthritis: Kv1.3 as a therapeutic target [PDF]

Biochemical Pharmacology, 2019
Rheumatoid arthritis (RA) is a serious autoimmune disease that has severe impacts on both the wellbeing of patients and the economy of the health system. Similar to many autoimmune diseases, RA concurs with a long evolution, which eventually results in highly debilitating symptoms. Therapeutic treatments last for long periods during RA.
Serrano-Albarrás, Antonio, Cirera-Rocosa, Sergi, Sastre Martinez, Daniel, Estadella, Irene, Felipe Campo, Antonio   +4 more
openaire   +3 more sources

Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease

, 2021
Kv1.3 potassium channels, expressed by proinflammatory central nervous system mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating neuroinflammation in Alzheimer's disease (AD).
Seyfried, Nicholas T, Wood, Levi B, Rayaprolu, Sruti, Gao, Tianwen, Galipeau, Jacques, Bitarafan, Sara, Chen, Michael J, Rangaraju, Srikant, Ramesha, Supriya, Dammer, Eric B, Katz, David J, Wulff, Heike, Bowen, Christine A, Engstrom, Amanda K, Nguyen, Hai M, Xiao, Hailian, Levey, Allan I, Giver, Cynthia R, Nwabueze, Ngozi, Pennati, Andrea, Waller, Edmund K, Hai M. Nguyen, Cynthia R. Giver, Supriya Ramesha, Andrea Pennati, Hailian Xiao, Sruti Rayaprolu, Allan I. Levey, Christine A. Bowen, Jacques Galipeau, David J. Katz, Ngozi Nwabueze, Sara Bitarafan, Levi B. Wood, Srikant Rangaraju, Tianwen Gao, Edmund K. Waller, Amanda K. Engstrom, Michael J. Chen, Eric B. Dammer, Heike Wulff, Nicholas T. Seyfried   +41 more
core   +1 more source

Physiological role of Kv1.3 channel in T lymphocyte cell investigated quantitatively by kinetic modeling.

PLoS ONE, 2014
Kv1.3 channel is a delayed rectifier channel abundant in human T lymphocytes. Chronic inflammatory and autoimmune disorders lead to the over-expression of Kv1.3 in T cells.
Panpan Hou, Rong Zhang, Yongfeng Liu, Jing Feng, Wei Wang, Yingliang Wu, Jiuping Ding   +6 more
doaj   +1 more source

Kv1.3: a multifunctional channel with many pathological implications [PDF]

Expert Opinion on Therapeutic Targets, 2017
Ion channels are transmembrane proteins that form aqueous pores driving ions through the plasma membrane in favor of an electrochemical gradient.
Antonio, Serrano-Albarrás, Irene, Estadella, Sergi, Cirera-Rocosa, María, Navarro-Pérez, Antonio, Felipe   +4 more
openaire   +2 more sources

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway [PDF]

Kv1.3 is a multifunctional potassium channel implicated in multiple pathologies, including cancer. However, how it is involved in disease progression is not fully clear.
Bachmann M., Checchetto V., Varanita T., Bonesso D., Leanza L., Gulbins E., Romualdi C., Szabo I., Doni D., Carpanese V., Prosdocimi E., Peruzzo R., Carrer A., Rettel M., Felipe A., Perez-Verdaguer M., Muccioli S., Velle A., Festa M., Todesca L. M., Costantini P., Cendron L., Stein F., Edwards M. J.   +23 more
core   +1 more source

Chlorpromazine directly inhibits Kv1.3 channels by facilitating the inactivation of channels

Molecular Brain
Kv1.3 channels in microglia are pivotal in regulating neuroinflammation. The antipsychotic chlorpromazine (CPZ) demonstrates anti-inflammatory effects by decreasing Kv1.3 activity in mPFC microglia.
Seo-In Park, Soobeen Hwang, Young Lee, Hee-Yoon Lee, Soohyun Kim, Junseo Hong, Su-Hyun Jo, Se-Young Choi   +7 more
doaj   +1 more source

Review on Biological Characteristics of Kv1.3 and Its Role in Liver Diseases

Frontiers in Pharmacology, 2021
The liver accounts for the largest proportion of macrophages in all solid organs of the human body. Liver macrophages are mainly composed of cytolytic cells inherent in the liver and mononuclear macrophages recruited from the blood. Monocytes recruitment
Junda Liu, Junda Liu, Junda Liu, Xiong-Wen Lv, Xiong-Wen Lv, Lei Zhang, Lei Zhang, Hua Wang, Hua Wang, Jun Li, Jun Li, Baoming Wu, Baoming Wu   +12 more
doaj   +1 more source