Results 81 to 90 of about 5,262 (204)

The potassium channel Kv1.3 as a therapeutic target for immunocytoprotection after reperfusion

Annals of Clinical and Translational Neurology, 2021
Objective The voltage‐gated potassium channel Kv1.3, which is expressed on activated, disease‐associated microglia and memory T cells, constitutes an attractive target for immunocytoprotection after endovascular thrombectomy (EVT).
Yi‐Je Chen, Yanjun Cui, Latika Singh, Heike Wulff   +3 more
doaj   +1 more source

Lack of Structural Change in Olfactory Circuitry Following Fecal Microbiome Transplant From Donors Subjected to Diet‐induced Obesity

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Fecal microbiome transplant from obese donor mice evokes microbiota changes that are not sufficient to change olfactory synaptic structure or glucose sensitivity in control‐fat (CF) fed recipient mice. FMT CF, fecal microbiome transplantation from control‐fat (CF) fed donors; FMT MHF, fecal microbiome transplantation from moderately high‐fat (MHF) fed ...
Ashley M. Loeven, Franklin A. Pacheco, Amber N. Brown, Debra Ann Fadool   +3 more
wiley   +1 more source

Towards a digital cancer cell twin: External pharmacological validation of a mechanistic A549 electrophysiology model

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
A mechanistic in‐silico model of A549 lung adenocarcinoma electrophysiology reproduces drug‐modulated ion‐channel responses across wild‐type and erlotinib‐resistant phenotypes. By accurately capturing KCa1.1 and KCa3.1 inhibition and phenotype‐specific KCa remodelling within biologically plausible bounds, the model provides a validated foundation for ...
Celine Desoyer, Martin Ruf, Christian Baumgartner   +2 more
wiley   +1 more source

The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer

Frontiers in Physiology, 2013
Voltage-dependent K+ channels (Kv) are involved in a number of physiological processes, including immunomodulation, cell volume regulation, apoptosis as well as differentiation.
Núria eComes, Joanna eBielanska, Albert eVallejo-Gracia, Antonio eSerrano-Albarrás, Laura eMarruecos, Diana eGómez, Concepció eSoler, Enric eCondom, Santiago eRamón y Cajal, Javier eHernández-Losa, Joan Carles eFerreres, Antonio eFelipe   +11 more
doaj   +1 more source

Models of cardiomyocyte–non‐myocyte electrical interactions

The Journal of Physiology, Volume 604, Issue 4, Page 1607-1628, 15 February 2026.
Abstract figure legend Cardiomyocyte–non‐myocyte (CM–NM) electrotonic coupling. Left: conceptual contact‐based interactions between CM and other NM via connexin (Cx) proteins. Three basic scenarios are proposed: (i) ‘zero‐sided coupling’ where there are no electrical connections between CM and NM, (ii) ‘single‐sided coupling’ where NM are connected to ...
Ana Simon‐Chica, Axel Loewe, Peter Kohl   +2 more
wiley   +1 more source

Differential localization of Kv1.3 and KCa3.1 in migrating T cells.

, 2012
A. Distribution of Kv1.3 and KCa3.1 at the uropod. T cells were transiently transfected with either YFP-KCa3.1 or GFP-Kv1.3 (green) and stained with anti-CD44 antibody (uropod; red) without permeabilization.
Zerrin Kuras (139695), Laura Conforti (105916), Ameet A. Chimote (139698), Yeo-Heung Yun (139696), Lisa Neumeier (139700)   +4 more
core   +1 more source

Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation

Pharmacological Research
Macrophages play crucial roles in regulating both homeostatic and inflammatory responses, with classical activated (M1) and alternatively activated (M2) subsets defined by the surrounding micro-environment.
Yanshan Chen, Yuanxing Zhi, Hailin Zhong, Liang Ma, Xinpei Gu, Yijing Cai, Jingjing Huang, Xin Yi, Xiaoyan Wu, Ken Kin Lam Yung, Pingzheng Zhou   +10 more
doaj   +1 more source

Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation

Cell Communication and Signaling, 2018
Background In T cells, the Kv1.3 and the KCa3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during TEM cell activation, the number of Kv1.3 channels on the cell membrane dramatically increases.
José Ignacio Veytia-Bucheli, Juana María Jiménez-Vargas, Erika Isabel Melchy-Pérez, Monserrat Alba Sandoval-Hernández, Lourival Domingos Possani, Yvonne Rosenstein   +5 more
doaj   +1 more source

Silencing of SLC6A1 Enhanced Cell Apoptosis in Prostate Cancer Through a Mitochondrial Mechanism

Advances in Urology, Volume 2026, Issue 1, 2026.
Objective The present study aims to elucidate the molecular mechanisms underlying the association between solute carrier family 6 member 1 (SLC6A1) and the aggressive progression of prostate cancer, with a particular emphasis on its relationship with mitochondrial function.
Chaojiang Chen, Ranting Wang, Zhuoyuan Lin, Jianxin Li, Yu Zheng, Kostis Gyftopoulos   +5 more
wiley   +1 more source

Immunosuppressive effects of new thiophene-based KV1.3 inhibitors

, 2023
: Voltage-gated potassium channel KV1.3 inhibitors have been shown to be effective in preventing T-cell proliferation and activation by affecting intracellular Ca2+ homeostasis.
Sala, Cesare, Montalbano, Alberto, Hendrickx, Louise Antonia, Altadonna, Ginevra Chioccioli, Pinheiro-Junior, Ernesto Lopes, Tomasic, Tihomir, Becchetti, Andrea, Van Theemsche, Kenny, Masic, Lucija Peterlin, Peigneur, Steve, Labro, Alain J., Arcangeli, Annarosa, Ilas, Janez, Pardo, Luis A., Gubic, Spela, Tytgat, Jan   +15 more
core