Results 101 to 110 of about 5,262 (204)

Elevated Anxiety and Impaired Attention in Super-Smeller, Kv1.3 Knockout Mice

Frontiers in Behavioral Neuroscience, 2018
It has long been recognized that olfaction and emotion are linked. While chemosensory research using both human and rodent models have indicated a change in emotion can contribute to olfactory dysfunction, there are few studies addressing the ...
Zhenbo Huang, Zhenbo Huang, Carlie A. Hoffman, Brandon M. Chelette, Brandon M. Chelette, Nicolas Thiebaud, Nicolas Thiebaud, Debra A. Fadool, Debra A. Fadool, Debra A. Fadool   +9 more
doaj   +1 more source

Therapeutic potential of voltage-dependent potassium channel subtype 1.3 blockade in alleviating macrophage-related renal inflammation and fibrogenesis

Cell Death Discovery
Macrophage polarization and infiltration are notable characteristics of kidney injury and fibrosis. Although voltage-dependent potassium channel subtype (Kv) 1.3 is involved in macrophage-induced inflammation, its precise mechanism has not been ...
Sha-sha Li, Yan Liang, Jia-wei Kong, Qi Zhang, Jing-rong Qian, Li-xia Yu, Qi-feng Liu   +6 more
doaj   +1 more source

A sex-dependent role of Kv1.3 channels from macrophages in metabolic syndrome

Frontiers in Physiology
IntroductionCoronary artery disease (CAD) is the foremost single cause of mortality and disability globally. Patients with type 2 diabetes (T2DM) have a higher incidence of CAD, and poorer prognosis.
Diego A. Peraza, Diego A. Peraza, Lucía Benito-Salamanca, Lucía Benito-Salamanca, Sara Moreno-Estar, Sara Moreno-Estar, Esperanza Alonso, Esperanza Alonso, José R. López-López, José R. López-López, M. Teresa Pérez-Garcia, M. Teresa Pérez-Garcia, Pilar Cidad, Pilar Cidad   +13 more
doaj   +1 more source

ROLE OF KV1.3 CHANNELS IN INTIMAL HYPERPLASIA

Journal of the American College of Cardiology, 2012
Resumen del poster presentado al American College of Cardiology - 61st Annual Scientific Seesion & Expo celebrado en Chicago (US) del 24 al 27 de marzo de 2012.
Novensa, Mercè Roquè. Laura, Cidad, Pilar, Batlle, Montserrat, Miguel-Velado, Eduardo, Alonso, Esperanza, Pérez-García, Teresa, López, José Ramón, Heras, Magda   +7 more
openaire   +1 more source

Exploring the mechanism accounting for Kv1.3-STAT3 interaction and consequent alterations of cancer-relevant pathways

reservedKv1.3, a member of the Shaker Kv1 channel family, has wide expression in excitable and non-excitable cells and it is involved in different physiological processes. Aberrant expression of Kv1.3 has also been correlated to many pathological states,
PUTNIK, MILENA
core  

Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation

, 2000
Microglia activate following numerous acute insults to the brain, including oxygen/glucose deprivation (OGD), and both protein tyrosine kinases (PTKs) and K+ channels have been implicated in their activation.
Schlichter, Lyanne C., Lyanne C Schlichter, Francisco S Cayabyab, Khanna, Rajesh, Cayabyab, Francisco S., Owen T Jones, Rajesh Khanna, Jones, Owen T.   +7 more
core   +1 more source

Long‐term obesogenic diet and targeted deletion of potassium channel Kv1.3 have differing effects on voluntary exercise in mice

Physiological Reports, 2019
Voluntary exercise is frequently employed as an intervention for obesity. The voltage‐gated potassium channel Kv1.3 is also receiving attention as a therapeutic target for obesity, in addition to potential therapeutic capabilities for neuroinflammatory ...
Brandon M. Chelette, Abigail M. Thomas, Debra Ann Fadool   +2 more
doaj   +1 more source

Meth increased Kv1.3 protein expression rather than Kv1.5.

, 2014
Microglial cells were incubated with Meth, and the level of Kv1.3, Kv1.5 proteins were detected by western-blot. (A) Meth (0, 100,300 µM) up-regulated Kv1.3 protein in a concentration dependent manner.
Jun Wang (5906), Hang Xiao (400864), Rong Gao (476219), Wenyi Qian (522582), Jing Zhou (168494), Pan Yu (522583), Jingjing Zhao (129177), Lei Jiang (73366), Jingli Liu (296642)   +8 more
core   +1 more source

The Phosphorylation of Kv1.3

The voltage-dependent potassium channel Kv1.3 is a potential target for cancer therapies. This channel exhibits a complex repertoire of physiological functions such as proliferation, activation, insulin sensitivity, nerve action potential and apoptosis among others.
Navarro-Pérez, María||, Estadella, Irene||, Benavente-Garcia, Anna, Orellana Fernández, Ruth||, Petit Montserrat, Anna||, Ferreres Piñas, Joan Carles||, Felipe, Antonio||   +6 more
openaire   +1 more source

Kv1.3: The perfect opening of the platelet voltage gate

The Journal of Physiology, 2010
Potassium channels are a vast family of transmembrane molecules with diverse functions in many cell types. They are subdivided according to mechanistic and structural criteria; the largest subclass comprising the voltage-gated K+-selective (Kv) channels.
openaire   +3 more sources