Results 111 to 120 of about 5,262 (204)

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

, 2017
Voltage-gated Kv1.3 and Ca2+-dependent KCa3.1 are the most prevalent K+ channels expressed by human and rat T cells. Despite the preferential upregulation of Kv1.3 over KCa3.1 on autoantigen-experienced effector memory T cells, whether Kv1.3 is required ...
Wyne P. Lee, Jun Chen, Juan Zhang, Susmith Mukund, David H. Hackos, Jason DeVoss, Jane L. Grogan, Eugene Y. Chiang, Surinder Jeet, Patrick Caplazi, Tianbo Li, Ivan Peng, Søren Warming, Christopher M. Koth   +13 more
core   +1 more source

OsK1 peptide inhibited voltage-gated Kv1.3 currents in human CD4 T cells and CHO cells transfected with recombinant human Kv1.3.

, 2017
OsK1 peptide inhibited human Kv1.3 mediated whole cell currents in a concentration dependent manner in human CD4 T cells (A). Potency of OsK1 peptide on Kv1.3 currents in purified human CD4 T cells and Kv1.3 transfected CHO cells were determined and IC50
Yi Liu (36759), Alan D. Wickenden (1971214), Wai-Ping Fung-Leung (509891), Xuejun Liu (427262), Ronald V. Swanson (2948145), Karen Ngo (509893), Nancy Wu (816673), Wilson Edwards (3687064), Julianty Angsana (3687061), Glenda Castro (3687058)   +9 more
core   +1 more source

Kv1.3 csatorna funkcionális expressziójának vizsgálata melanoma sejtvonalban

A Kv1.3 feszültségfüggő káliumcsatorna fontos szerepet játszik az immunsejtek működésében, valamint egyes daganattípusokban is megfigyelhető az expressziója, ezért potenciális terápiás célpontként szolgálhat.
Bakondi, Blanka
core  

Kv1.3 channels regulate synaptic transmission in the nucleus of solitary tract

, 2011
The voltage-gated K+channel Kv1.3 has been reported to regulate transmitter release in select central and peripheral neurons. In this study, we evaluated its role at the synapse between visceral sensory afferents and secondary neurons in the nucleus of ...
Patricia A. Glazebrook, Caroline Padro, Michelle Kane-Sutton, Diana L. Kunze, Angelina Ramirez-Navarro, David D. Kline   +5 more
core   +1 more source

Kv1.3 and Kv1.5 channels in leukocytes

, 2016
[eng] Voltage dependent potassium channels are a group of plasma membrane ion channels with a key role in the immune system as the predominant ion channels controlling the resting membrane potential and tuning intracellular Ca2+ signaling in lymphocytes, monocytes, macrophages, and dendritic cells.
openaire   +2 more sources

Potassium channels as an ionic checkpoint in tumor immunity. [PDF]

Front Pharmacol
Wang H, Zhang Y, Jiang S, Li X, Zheng Y, Wang Y, Xu Y, Xia C, Yan Y.   +8 more
europepmc   +1 more source

Selective Kv1.3 inhibition promotes M2 microglial polarization, accelerates hematoma resolution, and improves neurological recovery following collagenase-induced spontaneous intracerebral hemorrhage in mice. [PDF]

Vet World
Saleeon W, Vattarakorn A, Thongta N, Boondam Y, Wanasuntronwong A, Watanapa WB, Tapechum S, Pakaprot N.   +7 more
europepmc   +1 more source

Heteroligomeric interactions of the Kv1.3 channelosome

, 2017
Voltage-gated potassium channels are proteins that allow the flux of potassium ions across the plasma membrane in response to a voltage stimulus. Those proteins were initially described in nervous system as the repolarization entities posterior to a depolarization.
openaire   +1 more source

<i>Kcna3</i> Deficiency Promotes Renin-Associated Hypertension Through Ca²⁺-Dependent AKT-PKA-CREB Signaling. [PDF]

Biomolecules
Wang Y, Sun S, Zhang Y, Li G, Xu Y, Shi Y, Jose PA, Yang Z, Liu X, Jiang X.   +9 more
europepmc   +1 more source

Potassium channel Kv1.3 (KCNA3) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources