Results 41 to 50 of about 5,262 (204)
Cell & Bioscience, 2017 Background Specific and selective peptidic blockers of Kv1.3 channels can serve as a valuable drug lead for treating T cell-mediated autoimmune diseases, and scorpion venom is an important source of kv1.3 channel inhibitors.
Yan Zou +10 more
doaj +1 more source
Characterization of the role of Kv1.3 Potassium channel in Macrophages and regulatory T lymphocytes
, 2023 reservedSeveral evidences have documented a close relationship between ion channels and cancer, supporting a pivotal role for Potassium channels in cancer therapy.
BONETTO, VITTORIA
core
Use of Kv1.3 Blockers for Inflammatory Skin Conditions [PDF]
Current Medicinal Chemistry, 2010 Recent results using animal models of inflammatory skin conditions have shown that blockers of the voltage-gated potassium channel, Kv1.3 hold great promise for clinical utility. Kv1.3 blockers act as immunosuppressants by modulating the various subsets of inflammatory T and B cells involved in autoimmune disorders.
W, Nguyen +6 more
openaire +2 more sources
Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
Nature Communications, 2022 The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune responses. Here, the authors report structures of the Kv1.3 potassium channel with and without immunoglobulin modulators, shedding light on the ...
Purushotham Selvakumar +10 more
doaj +1 more source
Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States
Glia, Volume 74, Issue 10, October 2026.Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar +3 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2015 Background/Aims: Pharmacological inhibition of the potassium channel Kv1.3 has been shown to selectively kill B cells from patients with chronic lymphocytic leukemia (B-CLL).
Ildiko Szabo +4 more
doaj +1 more source