Optimizing Scorpion Toxin Processing through Artificial Intelligence [PDF]
ToxinsScorpion toxins are relatively short cyclic peptides (
Adam Psenicnik +6 more
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Transcriptomic Analysis Reveals Diverse Expression of Scorpion Toxin Genes in Mesobuthus martensii [PDF]
ToxinsScorpions, an ancient group of venomous invertebrates, have existed for over 430 million years. Their toxins, important for predation and defense, exhibit a variety of biological and pharmacological activities.
Zhongxian Yang +5 more
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Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin [PDF]
Nature Communications, 2021 The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique ...
Daohua Jiang +6 more
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Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel [PDF]
Toxins, 2015 The intense pain induced by scorpion sting is a frequent clinical manifestation. To date, there is no established protocol with significant efficacy to alleviate the pain induced by scorpion envenomation.
Md Abdul Hakim +6 more
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Venom gland transcriptomics and bioactivity profiling suggest bifunctional hyaluronidase activity in the venom of Mesobuthus crucittii (Scorpiones: Buthidae) [PDF]
Frontiers in Molecular BiosciencesIntroductionScorpion venom is a rich source of bioactive molecules with promising biomedical applications. Hyaluronidases are venom-associated enzymes that facilitate toxin diffusion by degrading extracellular matrix glycosaminoglycans, yet their ...
Masoumeh Baradaran +5 more
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Electrophysiological Characterization of the Venom and Toxins from the Scorpion Tityus championi Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief [PDF]
BiomoleculesScorpion neurotoxins are small peptides that target ion channels and offer opportunities for novel therapeutic discovery. This study analyzed the functional effects of the venom and toxins from the Costa Rican endemic scorpion, Tityus championi ...
Galit Akerman-Sánchez +9 more
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A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain [PDF]
Cell, 2019 John V Lin King +2 more
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Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations [PDF]
Nature CommunicationsScorpion toxins block potassium channels, disrupting cellular excitability and causing symptoms such as pain, muscle spasms, or paralysis. Here, we use an integrated structural biology approach to uncover the binding mode of the scorpion toxin ...
Denis Qoraj +12 more
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Toxins, 2021 Body tissue and venom glands from an eastern population of the scorpion Centruroides vittatus (Say, 1821) were homogenized and molecular constituents removed to characterize putative sodium β toxin gene diversity, RT-qPCR, transcriptomic, and proteomic ...
Aimee Bowman +4 more
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The European Zoological Journal, 2022 Scorpion venom plays an important role in scorpion predation, competition, communication, and defense. In this study, the species identification of Shandong scorpion and the analysis of venom extracted from male and female scorpion at the transcriptome ...
Y. Yang +12 more
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