Results 1 to 10 of about 10,029 (219)

Optimizing Scorpion Toxin Processing through Artificial Intelligence [PDF]

Toxins
Scorpion toxins are relatively short cyclic peptides (
Adam Psenicnik, Andres A. Ojanguren-Affilastro, Matthew R. Graham, Mohamed K. Hassan, Mohamed A. Abdel-Rahman, Prashant P. Sharma, Carlos E. Santibáñez-López   +6 more
doaj   +5 more sources

Transcriptomic Analysis Reveals Diverse Expression of Scorpion Toxin Genes in Mesobuthus martensii [PDF]

Toxins
Scorpions, an ancient group of venomous invertebrates, have existed for over 430 million years. Their toxins, important for predation and defense, exhibit a variety of biological and pharmacological activities.
Zhongxian Yang, Haiquan Wang, Yan Zhao, Jianyu Huang, Chao Zhang, Zhiyong Di   +5 more
doaj   +2 more sources

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin [PDF]

Nature Communications, 2021
The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique ...
Daohua Jiang, Lige Tonggu, Tamer M. Gamal El-Din, Richard Banh, Régis Pomès, Ning Zheng, William A. Catterall   +6 more
doaj   +2 more sources

The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening. [PDF]

PLoS ONE, 2015
We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav)
Thalita S Camargos, Frank Bosmans, Frank Bosmans, Solange C Rego, Caroline B F Mourão, Elisabeth F Schwartz   +5 more
doaj   +6 more sources

Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel [PDF]

Toxins, 2015
The intense pain induced by scorpion sting is a frequent clinical manifestation. To date, there is no established protocol with significant efficacy to alleviate the pain induced by scorpion envenomation.
Md Abdul Hakim, Wenbin Jiang, Lei Luo, Bowen Li, Shilong Yang, Yuzhu Song, Ren Lai   +6 more
doaj   +2 more sources

Reduced Toxicity of Centruroides vittatus (Say, 1821) May Result from Lowered Sodium β Toxin Gene Expression and Toxin Protein Production

Toxins, 2021
Body tissue and venom glands from an eastern population of the scorpion Centruroides vittatus (Say, 1821) were homogenized and molecular constituents removed to characterize putative sodium β toxin gene diversity, RT-qPCR, transcriptomic, and proteomic ...
Aimee Bowman, Chloe Fitzgerald, Jeff F. Pummill, Douglas D. Rhoads, Tsunemi Yamashita   +4 more
doaj   +1 more source

Transcriptome analysis of Mesobuthus martensii revealed the differences of their toxins between females and males

The European Zoological Journal, 2022
Scorpion venom plays an important role in scorpion predation, competition, communication, and defense. In this study, the species identification of Shandong scorpion and the analysis of venom extracted from male and female scorpion at the transcriptome ...
Y. Yang, Y. Zhu, Y. Luo, Q. Liu, X. Hua, J. Li, F. Gao, J. Hofer, X. Gao, L. Xiao, X. Song, S. Gao, R. Hao   +12 more
doaj   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. [PDF]

PLoS ONE, 2013
BACKGROUND: Recently, a new subfamily of long-chain toxins with a Kunitz-type fold was found in scorpion venom glands. Functionally, these toxins inhibit protease activity and block potassium channels.
Zongyun Chen, Fan Luo, Jing Feng, Weishan Yang, Danyun Zeng, Ruiming Zhao, Zhijian Cao, Maili Liu, Wenxin Li, Ling Jiang, Yingliang Wu   +10 more
doaj   +1 more source

The Pharmacological and Structural Basis of the AahII–NaV1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody

Frontiers in Pharmacology, 2022
Scorpion α-toxins are neurotoxins that target the fast inactivation mechanism of voltage-gated sodium (NaV) channels leading to several neuro- and cardiotoxic effects in mammals.
Riadh Hmaidi, Riadh Hmaidi, Ayoub Ksouri, Rahma Benabderrazek, Viviane Antonietti, Pascal Sonnet, Mathieu Gautier, Balkiss Bouhaouala-Zahar, Balkiss Bouhaouala-Zahar, Halima Ouadid-Ahidouch   +9 more
doaj   +1 more source