Results 41 to 50 of about 146,692 (204)

Neutralizing Dromedary-Derived Nanobodies Against BotI-Like Toxin From the Most Hazardous Scorpion Venom in the Middle East and North Africa Region

Frontiers in Immunology, 2022
Scorpion envenoming is a severe health problem in many regions causing significant clinical toxic effects and fatalities. In the Middle East/North Africa (MENA) region, Buthidae scorpion stings are responsible for devastating toxic outcomes in human. The
Rahma Ben Abderrazek, Ayoub Ksouri, Faten Idoudi, Sayda Dhaouadi, Emna Hamdi, Cécile Vincke, Cécile Vincke, Azer Farah, Zakaria Benlasfar, Hafedh Majdoub, Mohamed El Ayeb, Serge Muyldermans, Balkiss Bouhaouala-Zahar, Balkiss Bouhaouala-Zahar, Balkiss Bouhaouala-Zahar   +14 more
doaj   +1 more source

Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus

Journal of Toxicology, 2012
K+ channels selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitable and nonexcitable cells. Their activation allows the cell to repolarize after action potential firing and reduces excitability ...
Marie-France Martin-Eauclaire, Pierre E. Bougis   +1 more
doaj   +1 more source

Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.: Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin

, 2006
International audienceVoltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown.
Scheuer, Todd, Cestèle, Sandrine, Qu, Yusheng, Sampieri, François, Catterall, William, A., Yarov-Yarovoy, Vladimir, Catterall, William,   +6 more
core   +1 more source

Bioactivity profiling of linear venom peptides from Italian small wood‐scorpion (Euscorpius italicus)

Pest Management Science, EarlyView.
Functional screening pipeline of venom peptides from Euscorpius italicus reveal their activity towards globally important pest insects, bacteria, and cells – providing insight on the potential and function of arachnid venom peptides. Abstract BACKGROUND Rising host‐expansion and the global spread of pest insects, confront agricultural sectors with ...
Maurice Pierry, Ludwig Dersch, Jonas Krämer, Lennart Schulte, Ignazio Avella, Tobias Kessel, Kornelia Hardes, Michael Marner, Jens Grotmann, Maximilian Seip, Till F. Schäberle, Tim Lüddecke   +11 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Scorpion toxin peptide action at the ion channel subunit level [PDF]

, 2017
This review categorizes functionally validated actions of defined scorpion toxin (SCTX) neuropeptides across ion channel subclasses, highlighting key trends in this rapidly evolving field.
Housley, David M., Housley, Gary D., Jennings, Ernest A., Liddell, Michael J.   +3 more
core   +1 more source

Hadrurid Scorpion Toxins: Evolutionary Conservation and Selective Pressures

Toxins, 2019
Scorpion toxins are thought to have originated from ancestral housekeeping genes that underwent diversification and neofunctionalization, as a result of positive selection. Our understanding of the evolutionary origin of these peptides is hindered by the
Carlos E. Santibáñez-López, Matthew R. Graham, Prashant P. Sharma, Ernesto Ortiz, Lourival D. Possani   +4 more
doaj   +1 more source

Art v 1 and Amb a 4 Co‐Sensitization Identifies Italian Patients at Risk for Mugwort‐Celery‐Spice Syndrome

Allergy, EarlyView.
Three molecular profiles identified among Art v 1/Amb a 4‐sensitized patients: Art v 1 monosensitization, Amb a 4 monosensitization, and dual sensitization to both allergens. Art v 1 monosensitization was predominantly associated with allergic rhinitis, reflecting a classical airborne allergy pattern.
Enrico Scala, Gabriella Cusa, Valeria Villella, Damiano Abeni, Mauro Giani, Emma Cristina Guerra, Maria Locanto, Giorgia Meneguzzi, Lia Pirrotta, Donato Quaratino, Alessandra Zaffiro, Elisabetta Caprini, Maria Barrale, Ignazio Brusca, Valerio Pravettoni, Lorenzo Cecchi, Danilo Villalta, Martina Aumayr, Irene Mittermann, Christian Lupinek, Riccardo Asero   +20 more
wiley   +1 more source

X-ray Structure of Native Scorpion Toxin BmBKTx1 by Racemic Protein Crystallography Using Direct Methods

, 2016
X-ray Structure of Native Scorpion Toxin BmBKTx1 by Racemic Protein Crystallography Using Direct ...
Valentina Tereshko (2394763), Kalyaneswar Mandal (1395685), Anthony A. Kossiakoff (237521), Brad L. Pentelute (2176072), Stephen B. H. Kent (1395679)   +4 more
core   +1 more source

Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels

Toxins, 2018
Scorpion venoms are a complex mixture of components. Among them the most important are peptides, which presents the capacity to interact and modulate several ion channel subtypes, including voltage-gated sodium channels (NaV).
Daniel Oliveira da Mata, Diogo Vieira Tibery, Leandro Ambrósio Campos, Thalita Soares Camargos, Steve Peigneur, Jan Tytgat, Elisabeth Ferroni Schwartz   +6 more
doaj   +1 more source