Results 61 to 70 of about 10,029 (219)

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

[Scorpion toxins and defensins].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 1998
Les venins de scorpion contiennent un grand nombre de neurotoxines peptidiques qui constituent un ensemble de familles molécu­laires à haut degré de polymorphisme, mais qui ont en commun une architecture semblable. Cette architecture se retrouve dans des peptides antibactériens circulants de la famille des défensines, qui s'apparentent tout ...
Goyffon, M, Landon, C.
openaire   +2 more sources

Revitalizing endangered mycocultural heritage in Mesoamerica: The case of the Tlahuica‐Pjiekakjoo culture

PLANTS, PEOPLE, PLANET, Volume 8, Issue 3, Page 907-923, May 2026.
The preservation and revitalization of mycocultural heritage, developed over centuries of human‐mushroom interaction, contributes to safeguarding both natural ecosystems and the promotion of sustainable rural development, one of the biggest global challenges currently faced by humankind.
Elisette Ramírez‐Carbajal, Magdalena Martínez‐Reyes, Olivia Ayala‐Vásquez, Rodríguez‐Evangelista Fabiola, Mayra Lagunes Reyes, Faustino Hernández‐Santiago, Mónica Rangel Villafranco, Fuqiang Yu, Jesús Pérez‐Moreno   +8 more
wiley   +1 more source

Pioneering Study on Rhopalurus crassicauda Scorpion Venom: Isolation and Characterization of the Major Toxin and Hyaluronidase

Frontiers in Immunology, 2020
Scorpionism is responsible for most accidents involving venomous animals in Brazil, which leads to severe symptoms that can evolve to death. Scorpion venoms consist of complexes cocktails, including peptides, proteins, and non-protein compounds, making ...
Caio B. Abreu, Karla C. F. Bordon, Felipe A. Cerni, Isadora S. Oliveira, Carla Balenzuela, Gabriel M. Alexandre-Silva, Karina F. Zoccal, Mouzarllem B. Reis, Mouzarllem B. Reis, Gisele A. Wiezel, Steve Peigneur, Ernesto L. Pinheiro-Júnior, Jan Tytgat, Tiago M. Cunha, Loic Quinton, Lúcia H. Faccioli, Eliane C. Arantes, Umberto Zottich, Manuela B. Pucca   +18 more
doaj   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source

Impact of Comorbidities on Clinical Outcomes and Quality of Life of Patients With Hormone Receptor‐Positive/Human Epidermal Growth Factor Receptor 2‐Negative (HR+/HER2−) Advanced Breast Cancer Treated With Palbociclib in the POLARIS Study

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Comorbidities, common in patients with advanced breast cancer (ABC), may impact survival outcomes and health‐related quality of life (HRQoL). Here, we report subgroup analyses on the basis of comorbidities of patients from POLARIS (NCT03280303), a prospective, observational study of patients with hormone receptor‐positive/human ...
Debu Tripathy, Joanne L. Blum, Meghan S. Karuturi, Steven McCune, Sobha Kurian, Mehdi M. Moezi, Daniel M. Anderson, Yan Ji, Timothy J. Pluard, John Migas, Shailendra Lakhanpal, Erin Jepsen, Yao Wang, Monica Z. Montelongo, Zhe Zhang, Joseph C. Cappelleri, Eric Gauthier, Gabrielle B. Rocque   +17 more
wiley   +1 more source

Scorpions from the primeval subgenus Archaeotityus produce putative homologs of Tityus serrulatus toxins active on voltage-gated sodium channels

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
It has been proposed that the subgenus Archaeotityus comprises the most ancient species group within the medically important scorpion genus Tityus. cDNA encoding sodium-channel active toxins from the type species of this subgenus, Tityus clathratus ...
A Borges, MJ Jowers, S Bónoli, L De Sousa   +3 more
doaj   +1 more source

Dysphagia as the Sole Presentation of Lateral Medullary Syndrome in an Octagerian: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Lateral medullary syndrome (LMS) or Wallenberg's syndrome is usually caused by a cerebrovascular accident of the vertebral artery or the posterior inferior cerebellar artery (PICA), leading to damage to the dorsolateral aspects of the medulla oblongata.
Abera Kuma, Bereket A. Tegene, Sosena Sheleme, Shamil Nuri, Abdulkerim Girma, Sinetibeb Tadesse Amsalu   +5 more
wiley   +1 more source

Turning a Scorpion Toxin into an Antitumor Miniprotein [PDF]

Journal of the American Chemical Society, 2008
The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53 and are important molecular targets for anticancer therapy. Grafting four residues of p53 critical for MDM2/MDMX binding to the N-terminal alpha-helix of BmBKTx1, a scorpion toxin isolated from the venom of the Asian scorpion Buthus ...
Chong, Li, Min, Liu, Juahdi, Monbo, Guozhang, Zou, Changqing, Li, Weirong, Yuan, Davide, Zella, Wei-Yue, Lu, Wuyuan, Lu   +8 more
openaire   +2 more sources

Assembling an arsenal, the scorpion way

BMC Evolutionary Biology, 2008
Background For survival, scorpions depend on a wide array of short neurotoxic polypeptides. The venoms of scorpions from the most studied group, the Buthida, are a rich source of small, 23–78 amino acid-long peptides, well packed by either three or four ...
Mishmar Dan, Bar-Shalom Adi, Kozminsky-Atias Adi, Zilberberg Noam   +3 more
doaj   +1 more source