Results 51 to 60 of about 10,029 (219)

Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels

Toxins, 2018
Scorpion venoms are a complex mixture of components. Among them the most important are peptides, which presents the capacity to interact and modulate several ion channel subtypes, including voltage-gated sodium channels (NaV).
Daniel Oliveira da Mata, Diogo Vieira Tibery, Leandro Ambrósio Campos, Thalita Soares Camargos, Steve Peigneur, Jan Tytgat, Elisabeth Ferroni Schwartz   +6 more
doaj   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Environmental adaptation and functional diversity of calcin peptides from the venom of East Asian scorpions

Ecotoxicology and Environmental Safety
Toxins as naturally occurring hazardous substances, have evolved as a defense mechanism in organisms for survival. The expression of toxins is profoundly influenced by environmental factors, and the investigation of their correlation holds significant ...
Xiaoyu Hua, Zhixiao Yang, Li Xiao, Songyu Gao, Fengling Yang, Bilin Tao, Yi Wang, Jianguo Wang, Carmen R. Valdivia, Wei Chen, Wengeng Jiang, He Sun, Diguyan Wu, Marina Pozzolini, Lingxin Chen, Héctor H. Valdivia, Liang Xiao   +16 more
doaj   +1 more source

Scorpion envenomation-induced acute thrombotic inferior myocardial infarction

Türk Kardiyoloji Derneği Arşivi, 2016
The occurrence of a serious cardiac emergency following scorpion envenomation has rarely been reported and, when so, mostly presented as non-ST segment elevation myocardial infarction, cardiogenic shock, or myocarditis.
Ahmet Oytun Baykan, Mustafa Gür, Armağan Acele, Taner Şeker, Murat Çaylı   +4 more
doaj   +1 more source

First Assessment of Genetic Damage in the Speckled Cockroach (Nauphoeta cinerea) After Consumption of Lettuce (Lactuca sativa) Cultivated and Commercialized in Northeastern, Brazil

Environmental Toxicology, EarlyView.
ABSTRACT This study reports, for the first time, the use of the speckled cockroach Nauphoeta cinerea as a promising bioindicator for genotoxic monitoring. It was validated through control groups (both positive and negative) in addition to testing lettuce (Lactuca sativa ) samples from public street markets consumed by N. cinerea specimens in Pernambuco,
Aleson Aparecido da Silva, Eduardo Henrique da Silva Melo, Érima Maria de Amorim, Maria Gislaine Pereira, Claudia Rohde   +4 more
wiley   +1 more source

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

Toxins, 2016
To date, several families of peptide toxins specifically interacting with ion channels in scorpion venom have been described. One of these families comprise peptide toxins (called KTxs), known to modulate potassium channels.
Caroline M. Cremonez, Mohitosh Maiti, Steve Peigneur, Juliana Silva Cassoli, Alexandre A. A. Dutra, Etienne Waelkens, Eveline Lescrinier, Piet Herdewijn, Maria Elena de Lima, Adriano M. C. Pimenta, Eliane C. Arantes, Jan Tytgat   +11 more
doaj   +1 more source

The scorpion toxin and the potassium channel. [PDF]

Elife, 2013
The structure of a complex containing a toxin bound to a potassium ion channel has been solved for the first time, revealing how scorpions have designed toxins that can recognize and target the filter that controls the movement of potassium ions through these channels.
Swartz KJ.
europepmc   +4 more sources

Art v 1 and Amb a 4 Co‐Sensitization Identifies Italian Patients at Risk for Mugwort‐Celery‐Spice Syndrome

Allergy, EarlyView.
Three molecular profiles identified among Art v 1/Amb a 4‐sensitized patients: Art v 1 monosensitization, Amb a 4 monosensitization, and dual sensitization to both allergens. Art v 1 monosensitization was predominantly associated with allergic rhinitis, reflecting a classical airborne allergy pattern.
Enrico Scala, Gabriella Cusa, Valeria Villella, Damiano Abeni, Mauro Giani, Emma Cristina Guerra, Maria Locanto, Giorgia Meneguzzi, Lia Pirrotta, Donato Quaratino, Alessandra Zaffiro, Elisabetta Caprini, Maria Barrale, Ignazio Brusca, Valerio Pravettoni, Lorenzo Cecchi, Danilo Villalta, Martina Aumayr, Irene Mittermann, Christian Lupinek, Riccardo Asero   +20 more
wiley   +1 more source

Ligation of the abdominal esophagus decreases scorpion toxin-induced gastric secretion in rats Ligadura do esôfago abdominal diminui a secreção gástrica induzida por toxina de escorpião em ratos

Acta Cirúrgica Brasileira, 2004
PURPOSE: Scorpion toxin purified from Tityus serrulatus venom (Tx) induces an increase in volume, acidity and pepsin secretion in the gastric juice of rats. Ligation of oesophagus has been shown to reduce the acid gastric secretion in rats.
Claudia S. Vidal, Marcus Vinicius Melo Andrade, Gisele Viana, Alcino L. Silva, Tasso Moraes-Santos, Heloísa M. S. Gonzaga, José Renan Cunha-Melo   +6 more
doaj   +1 more source

Insects and Survival: A Review of Primary and Secondary Defense Strategies

Entomologia Experimentalis et Applicata, EarlyView.
Based on a review of three decades of literature, insect defense mechanisms are classified into primary (I) and secondary (II) mechanisms of behavioral, morphological, and chemical nature. These mechanisms have been recorded in 22 (I) and 20 (II) orders, respectively.
Lucas Fernandes Silva, Rodrigo Almeida Pinheiro, José Cola Zanuncio, Conceição Aparecida dos Santos   +3 more
wiley   +1 more source