Results 31 to 40 of about 146,692 (204)
hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]
PLoS ONE, 2013 The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma +5 more
doaj +1 more source
Rapidly improving acute myocarditis after a scorpion sting
Türk Kardiyoloji Derneği Arşivi, 2013 Scorpion stings are usually benign, but especially cardiovascular death has been reported due to complications. Local reactions at the site of the sting as well as organ dysfunction may be due to the effects of a systemic toxin.
Nermin Bayar +3 more
doaj +1 more source
Toxins, 2014 Long-chain scorpion toxins with four disulfide bridges exhibit various pharmacological features towards the different voltage-gated sodium channel subtypes. However, the toxin production still remains a huge challenge.
Tian Li +6 more
doaj +1 more source
Wheat germ in vitro translation to produce one of the most toxic sodium channel specific toxins
Bioscience Reports, 2014 Envenoming following scorpion sting is a common emergency in many parts of the world. During scorpion envenoming, highly toxic small polypeptides of the venom diffuse rapidly within the victim causing serious medical problems.
Wael Gad +6 more
doaj +1 more source
Turning a Scorpion Toxin into an Antitumor Miniprotein [PDF]
Journal of the American Chemical Society, 2008 The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53 and are important molecular targets for anticancer therapy. Grafting four residues of p53 critical for MDM2/MDMX binding to the N-terminal alpha-helix of BmBKTx1, a scorpion toxin isolated from the venom of the Asian scorpion Buthus ...
Chong, Li +8 more
openaire +2 more sources
Evolution Stings: The Origin and Diversification of Scorpion Toxin Peptide Scaffolds
Toxins, 2013 The episodic nature of natural selection and the accumulation of extreme sequence divergence in venom-encoding genes over long periods of evolutionary time can obscure the signature of positive Darwinian selection.
Kartik Sunagar +6 more
doaj +1 more source
Basal ganglia hemorrhage secondary to scorpion sting: a fatal presentation
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2020 Introduction Cerebrovascular manifestations are uncommon presentations of scorpion sting in the Indian subcontinent. Encephalopathy, cerebral edema, subarachnoid hemorrhage, non-hemorrhagic strokes, and cortical necrosis are a few CNS complications ...
Avirup Majumdar +4 more
doaj +1 more source
Target-Driven Evolution of Scorpion Toxins [PDF]
Scientific Reports, 2015 AbstractIt is long known that peptide neurotoxins derived from a diversity of venomous animals evolve by positive selection following gene duplication, yet a force that drives their adaptive evolution remains a mystery. By using maximum-likelihood models of codon substitution, we analyzed molecular adaptation in scorpion sodium channel toxins from a ...
Shangfei Zhang, Bin Gao, Shunyi Zhu
openaire +2 more sources
, 1969 The Scorpion has stung KSC. The interest shown in our first meager effort has been more than enough motivation to continue. But the rude manner in which the Scorpion was treated upon its arrival was shocking. There was nothing the Scorpion that warranted
The Scorpion Staff
core +1 more source
Accurate prediction of scorpion toxin functional properties from primary structures
, 2005 Scorpion toxins are common experimental tools for studies of biochemical and pharmacological properties of ion channels. The number of functionally annotated scorpion toxins is steadily growing, but the number of identified toxin sequences is increasing ...
Koh, JLY +13 more
core +1 more source