Results 31 to 40 of about 10,029 (219)

Characterization of a Novel BmαTX47 Toxin Modulating Sodium Channels: The Crucial Role of Expression Vectors in Toxin Pharmacological Activity

open access: yesToxins, 2014
Long-chain scorpion toxins with four disulfide bridges exhibit various pharmacological features towards the different voltage-gated sodium channel subtypes. However, the toxin production still remains a huge challenge.
Tian Li   +6 more
doaj   +1 more source

Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components [PDF]

open access: yes, 2010
Background Lychas mucronatus is one scorpion species widely distributed in Southeast Asia and southern China. Anything is hardly known about its venom components, despite the fact that it can often cause human accidents.
Zhao Ruiming   +6 more
core   +2 more sources

Inhibition of gastric emptying and intestinal transit in anesthetized rats by a Tityus serrulatus scorpion toxin

open access: yesBrazilian Journal of Medical and Biological Research, 2000
The effects of a fraction (T1) of Tityus serrulatus scorpion venom prepared by gel filtration on gastric emptying and small intestinal transit were investigated in male Wistar rats.
L.E.A. Troncon   +5 more
doaj   +1 more source

Spider neurotoxins targeting voltage-gated sodium channels [PDF]

open access: yes, 2005
The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides, and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate sodium channel gating and/or kinetics.
Little, MJ, Nicholson, GM
core   +1 more source

Southern African scorpion toxins: An overview

open access: yesToxicon, 2008
In southern Africa there are 130 species of scorpions and only a few species' venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the toxins and peptides identified up to date.
Du Plessis, L.H.   +2 more
openaire   +3 more sources

Basal ganglia hemorrhage secondary to scorpion sting: a fatal presentation

open access: yesThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2020
Introduction Cerebrovascular manifestations are uncommon presentations of scorpion sting in the Indian subcontinent. Encephalopathy, cerebral edema, subarachnoid hemorrhage, non-hemorrhagic strokes, and cortical necrosis are a few CNS complications ...
Avirup Majumdar   +4 more
doaj   +1 more source

Insect-selective spider toxins targeting voltage-gated sodium channels [PDF]

open access: yes, 2007
The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate Nav channel gating.
Nicholson, GM
core   +1 more source

Genomic organization of the KTX2 gene, encoding a `short' scorpion toxin active on K+ channels [PDF]

open access: yes, 1997
A single intron of 87 bp, close to the region encoding the C-terminal part of the signal peptide, was found in the gene of the `short' scorpion toxin kaliotoxin 2 of Androctonus australis acting on various types of K+ channels.
Legros, Christian   +2 more
core   +1 more source

Isolation, chemical and functional characterization of several new K+-channel blocking peptides from the venom of the scorpion Centruroides tecomanus [PDF]

open access: yes, 2018
K
Balajthy, András   +6 more
core   +1 more source

Neutralizing Dromedary-Derived Nanobodies Against BotI-Like Toxin From the Most Hazardous Scorpion Venom in the Middle East and North Africa Region

open access: yesFrontiers in Immunology, 2022
Scorpion envenoming is a severe health problem in many regions causing significant clinical toxic effects and fatalities. In the Middle East/North Africa (MENA) region, Buthidae scorpion stings are responsible for devastating toxic outcomes in human. The
Rahma Ben Abderrazek   +14 more
doaj   +1 more source

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