Results 21 to 30 of about 146,692 (204)

Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. [PDF]

PLoS ONE, 2013
BACKGROUND: Recently, a new subfamily of long-chain toxins with a Kunitz-type fold was found in scorpion venom glands. Functionally, these toxins inhibit protease activity and block potassium channels.
Zongyun Chen, Fan Luo, Jing Feng, Weishan Yang, Danyun Zeng, Ruiming Zhao, Zhijian Cao, Maili Liu, Wenxin Li, Ling Jiang, Yingliang Wu   +10 more
doaj   +1 more source

The Pharmacological and Structural Basis of the AahII–NaV1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody

Frontiers in Pharmacology, 2022
Scorpion α-toxins are neurotoxins that target the fast inactivation mechanism of voltage-gated sodium (NaV) channels leading to several neuro- and cardiotoxic effects in mammals.
Riadh Hmaidi, Riadh Hmaidi, Ayoub Ksouri, Rahma Benabderrazek, Viviane Antonietti, Pascal Sonnet, Mathieu Gautier, Balkiss Bouhaouala-Zahar, Balkiss Bouhaouala-Zahar, Halima Ouadid-Ahidouch   +9 more
doaj   +1 more source

Tb1, a Neurotoxin from Tityus bahiensis Scorpion Venom, Induces Epileptic Seizures by Increasing Glutamate Release

Toxins, 2020
Here, we report the neurotoxic effects aroused by the intracerebral injection (in rats) of Tb1, which is a neurotoxin isolated from Tityus bahiensis scorpion venom. Biochemical analyses have demonstrated that this toxin is similar to the gamma toxin from
Emidio Beraldo Neto, Lucas Alves de Freitas, Daniel Carvalho Pimenta, Ivo Lebrun, Ana L. A. Nencioni   +4 more
doaj   +1 more source

Recombinant expression and antigenicity of two peptide families of neurotoxins from Androctonus sp.

Journal of Venomous Animals and Toxins including Tropical Diseases, 2022
Background: Scorpion neurotoxins such as those that modify the mammalian voltage-gated sodium ion channels (Nav) are the main responsible for scorpion envenomation. Their neutralization is crucial in the production of antivenoms against scorpion stings.
Samuel Cardoso-Arenas, Herlinda Clement, Iván Arenas, Felipe Olvera, Fernando Zamudio, Figen Caliskan, Ligia Luz Corrales-García, Gerardo Corzo   +7 more
doaj   +1 more source

The scorpion toxin and the potassium channel. [PDF]

Elife, 2013
The structure of a complex containing a toxin bound to a potassium ion channel has been solved for the first time, revealing how scorpions have designed toxins that can recognize and target the filter that controls the movement of potassium ions through these channels.
Swartz KJ.
europepmc   +4 more sources

Chaperone-mediated native folding of a β-scorpion toxin in the periplasm of E.coli [PDF]

, 2014
Background: Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Cole, Ambrose R., Lampert, A., Wallace, Bonnie A., O’Reilly, A.O., Lopes, J.L.S.   +4 more
core   +1 more source

Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers

Pharmacological Research, 2023
Animal venom is an important evolutionary innovation in nature. As one of the most representative animal venoms, scorpion venom contains an extremely diverse set of bioactive peptides.
Zhiqiang Xia, Dangui He, Yingliang Wu, Hang Fai Kwok, Zhijian Cao   +4 more
doaj   +1 more source

Molecular Characterization of a Three-disulfide Bridges Beta-like Neurotoxin from Androctonus crassicauda Scorpion Venom [PDF]

Archives of Razi Institute, 2019
Scorpion venom is the richest source of peptide toxins with high levels of specific interactions with different ion-channel membrane proteins. The present study involved the amplification and sequencing of a 310-bp cDNA fragment encoding a beta-like ...
A. Jolodar
doaj   +1 more source

Turning a Scorpion Toxin into an Antitumor Miniprotein

, 2016
Turning a Scorpion Toxin into an Antitumor ...
Changqing Li (333970), Min Liu (45756), Wei-Yue Lu (2064952), Juahdi Monbo (2414362), Weirong Yuan (483828), Guozhang Zou (1631764), Chong Li (120471), Davide Zella (2414365), Wuyuan Lu (363836)   +8 more
core   +2 more sources

A non-lethal method for studying scorpion venom gland transcriptomes, with a review of potentially suitable taxa to which it can be applied.

PLoS ONE, 2021
Scorpion venoms are mixtures of proteins, peptides and small molecular compounds with high specificity for ion channels and are therefore considered to be promising candidates in the venoms-to-drugs pipeline.
Freek J Vonk, Mátyás A Bittenbinder, Harald M I Kerkkamp, Dwin G B Grashof, John P Archer, Sandra Afonso, Michael K Richardson, Jeroen Kool, Arie van der Meijden   +8 more
doaj   +2 more sources