The envenomation of general physiology throughout the last century. [PDF]
, 2017 Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders.
Sack, Jon T
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Molecular Characterization of a Three-disulfide Bridges Beta-like Neurotoxin from Androctonus crassicauda Scorpion Venom [PDF]
Archives of Razi Institute, 2019 Scorpion venom is the richest source of peptide toxins with high levels of specific interactions with different ion-channel membrane proteins. The present study involved the amplification and sequencing of a 310-bp cDNA fragment encoding a beta-like ...
A. Jolodar
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Bounded Coordinate-Descent for Biological Sequence Classification in High Dimensional Predictor Space [PDF]
, 2010 We present a framework for discriminative sequence classification where the learner works directly in the high dimensional predictor space of all subsequences in the training set.
Ifrim, Georgiana, Wiuf, Carsten
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Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds [PDF]
, 2016 Anuroctoxin (AnTx), a 35-amino-acid scorpion toxin containing four disulfide bridges, is a high affinity blocker of the voltage-gated potassium channel Kv1.3, but also blocks Kv1.2.
Bartok, Adam +9 more
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Target-Driven Evolution of Scorpion Toxins [PDF]
Scientific Reports, 2015 AbstractIt is long known that peptide neurotoxins derived from a diversity of venomous animals evolve by positive selection following gene duplication, yet a force that drives their adaptive evolution remains a mystery. By using maximum-likelihood models of codon substitution, we analyzed molecular adaptation in scorpion sodium channel toxins from a ...
Shangfei Zhang, Bin Gao, Shunyi Zhu
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Revista do Instituto de Medicina Tropical de São Paulo, 1989 Intravenous injection of scorpion toxin (Tityus serrulatus) in normal and Trypanosoma cruzi infected rats did not cause ultrastructural morphologic changes on enterochromaffin-like (ECL) cells of the stomach, although it induced a significant increase of
N. H. Toppa +6 more
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hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]
PLoS ONE, 2013 The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma +5 more
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: Maurocalcine transduction into cells [PDF]
, 2005 International audienceMaurocalcine (MCa) is a 33-amino-acid residue peptide toxin isolated from the scorpion Scorpio maurus palmatus. External application of MCa to cultured myotubes is known to produce Ca2+ release from intracellular stores.
Altafaj, Xavier +11 more
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Rapidly improving acute myocarditis after a scorpion sting
Türk Kardiyoloji Derneği Arşivi, 2013 Scorpion stings are usually benign, but especially cardiovascular death has been reported due to complications. Local reactions at the site of the sting as well as organ dysfunction may be due to the effects of a systemic toxin.
Nermin Bayar +3 more
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Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin [PDF]
, 2009 TsTX is an a-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for ...
BARRETO, S. A +5 more
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