Results 11 to 20 of about 10,029 (219)
Evolution Stings: The Origin and Diversification of Scorpion Toxin Peptide Scaffolds
Toxins, 2013 The episodic nature of natural selection and the accumulation of extreme sequence divergence in venom-encoding genes over long periods of evolutionary time can obscure the signature of positive Darwinian selection.
Kartik Sunagar +6 more
doaj +3 more sources
Hadrurid Scorpion Toxins: Evolutionary Conservation and Selective Pressures [PDF]
Toxins, 2019 Scorpion toxins are thought to have originated from ancestral housekeeping genes that underwent diversification and neofunctionalization, as a result of positive selection. Our understanding of the evolutionary origin of these peptides is hindered by the
Carlos E. Santibáñez-López +4 more
doaj +3 more sources
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain. [PDF]
Cell, 2019 Lin King JV +6 more
europepmc +2 more sources
Recombinant expression and antigenicity of two peptide families of neurotoxins from Androctonus sp.
Journal of Venomous Animals and Toxins including Tropical Diseases, 2022 Background: Scorpion neurotoxins such as those that modify the mammalian voltage-gated sodium ion channels (Nav) are the main responsible for scorpion envenomation. Their neutralization is crucial in the production of antivenoms against scorpion stings.
Samuel Cardoso-Arenas +7 more
doaj +1 more source
Toxins, 2020 Here, we report the neurotoxic effects aroused by the intracerebral injection (in rats) of Tb1, which is a neurotoxin isolated from Tityus bahiensis scorpion venom. Biochemical analyses have demonstrated that this toxin is similar to the gamma toxin from
Emidio Beraldo Neto +4 more
doaj +1 more source
Biotechnological Trends in Spider and Scorpion Antivenom Development [PDF]
, 2016 Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain.
Engmark, Mikael +5 more
core +6 more sources
Pharmacological Research, 2023 Animal venom is an important evolutionary innovation in nature. As one of the most representative animal venoms, scorpion venom contains an extremely diverse set of bioactive peptides.
Zhiqiang Xia +4 more
doaj +1 more source
Molecules, 2019 Scorpion toxins are well-known as the largest potassium channel peptide blocker family. They have been successfully proven to be valuable molecular probes for structural research on diverse potassium channels. The potassium channel pore region, including
Yonghui Zhao +4 more
doaj +1 more source
Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]
, 2014 BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A +4 more
core +2 more sources
PLoS ONE, 2021 Scorpion venoms are mixtures of proteins, peptides and small molecular compounds with high specificity for ion channels and are therefore considered to be promising candidates in the venoms-to-drugs pipeline.
Freek J Vonk +8 more
doaj +2 more sources