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Extreme Diversity of Scorpion Venom Peptides and Proteins Revealed by Transcriptomic Analysis: Implication for Proteome Evolution of Scorpion Venom Arsenal

Journal of Proteomics, 2012
Venom is an important genetic development crucial to the survival of scorpions for over 400 million years. We studied the evolution of the scorpion venom arsenal by means of comparative transcriptome analysis of venom glands and phylogenetic analysis of shared types of venom peptides and proteins between buthids and euscorpiids.
Zhijian Cao, Yibao Ma, Yingliang Wu
exaly   +3 more sources

Characterization of Peptide Components in the Venom of the Scorpion Liocheles Australasiae (Hemiscorpiidae)

Toxicon, 2007
Scorpion venoms are composed of a number of neurotoxic peptides. A variety of toxins have been isolated from the venoms of scorpions of the family Buthidae, however, little interest has been paid to non-Buthidae scorpions. In this study, we examined the toxicity of the venom of Liocheles australasiae (Hemiscorpiidae) to mice and crickets, and ...
Masahiro Miyashita   +2 more
exaly   +3 more sources

Evidence for the Existence of Insect Defensin‐Like Peptide in Scorpion Venom

IUBMB Life, 2000
AbstractInsect defensin refers to a group of antibacterial peptides derived from a variety of insect species as well as from scorpion and possessing a three‐dimensional structure highly similar to that of scorpion toxins. A full‐length cDNA encoding an insect defensin‐like peptide was isolated from the venom gland cDNA library of the Chinese ...
S, Zhu, W, Li, D, Jiang, X, Zeng
openaire   +2 more sources

Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch

Peptides, 2019
The scorpion Buthus martensii Karsch (BmK) has generated significant interest due to the presence of biologically active peptides in its venom. In the past decade, dozens of different peptides from BmK have been identified. Most of the peptides are neurotoxins and are responsible for the toxicity of BmK venom.
Zhongjie Li   +3 more
openaire   +2 more sources

Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution

Toxicon, 2015
Scorpion venoms include several compounds with different pharmacological activities. Within these compounds, toxins affecting ion channels are among the most studied. They are all peptides that have been classified based on their 3D structure, chain size and function.
Carlos E. Santibáñez-López   +1 more
openaire   +2 more sources

Anticancer and antimicrobial activities of scorpion venoms and their peptides

Toxin Reviews, 2017
AbstractScorpion venom is a natural biological resource that contains several components, which are not only responsible for death but also have a potential therapeutic activity. Scorpion venom has been used as traditional and folk therapy in various pathophysiological conditions.
openaire   +1 more source

Tityus serrulatus Hypotensins: A new family of peptides from scorpion venom

Biochemical and Biophysical Research Communications, 2008
Using a proteomic approach, a new structural family of peptides was put in evidence in the venom of the yellow scorpion Tityus serrulatus. Tityus serrulatus Hypotensins (TsHpt) are random-coiled linear peptides and have a similar bradykinin-potentiating peptide (BPP) amino acid signature.
Verano-Braga, T.   +8 more
openaire   +2 more sources

Scorpion Venom Peptides in Ophthalmology: Insights from the Babylonian Talmud

American Journal of Ophthalmology
Historical medical texts can reveal overlooked therapeutic approaches relevant to modern ophthalmology. This perspective revisits a remedy from the Babylonian Talmud prescribing a mixture of scorpion and kohl for an eye condition called buruqti (also transliterated as beroketi), traditionally translated as cataract.
David Maskill, Robert Morgan Blizzard
openaire   +2 more sources

Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins

Amino Acids, 2018
Besides key roles in prey capture and predator defense, scorpion venom also functions as internal immune agents protecting the venom gland from infection and external immune agents cleaning saprophytic microbes from their own body surfaces. However, antimicrobials (typically antimicrobial peptides, AMPs) in the venom often exist in low abundance that ...
Bin, Gao   +3 more
openaire   +2 more sources

Chlorotoxin and related peptides: Short insect toxins from scorpion venom

Russian Journal of Bioorganic Chemistry, 2014
Scorpion venom is a complex multicomponent mixture of biologically active substances, some of which possess very interesting properties and are used in quite unexpected fields. The family of chlorotoxin (CTX)-like peptides serves a good example. These toxins exhibit insecticidal activity, however, their molecular mechanism of action on insect organism ...
A A, Arzamasov   +2 more
openaire   +2 more sources

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