Results 91 to 100 of about 26,346 (266)

Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob disease [PDF]

, 2005
In recent studies, the amyloid form of recombinant prion protein (PrP) encompassing residues 89–230 (rPrP 89-230) produced in vitro induced transmissible prion disease in mice.
Adler, Andrew C. Gill, Barron, Barron, Bartz, Baskakov, Baskakov, Baskakov, Bessen, Bocharova, Caughey, Caughey, Chabry, Chen, Cohen, Deleault, Dickinson, Donne, Fischer, Fraser, Gabizon, Gabus, Gill, Gonzalez-Iglesias, Haire, Hill, Ilia V. Baskakov, Kocisko, Lasmézas, Lawson, Legname, Legname, Leonid Breydo, Manuelidis, McKinley, Notari, Oesch, Olga V. Bocharova, Pan, Paramithiotis, Parchi, Parchi, Pattison, Peretz, Peretz, Prusiner, Prusiner, Prusiner, Prusiner, Riek, Riek, Safar, Santoro, Satoh, Scott, Swietnicki, Tagliavini, Telling, Telling, Tremblay, Vadim V. Salnikov, Wadsworth, Warner, Wille, Wong, Yadavalli, Zou   +66 more
core   +2 more sources

Lessons learned and lingering uncertainties after seven years of chronic wasting disease management in Norway

Wildlife Biology, Volume 2025, Issue 5, September 2025.
Chronic wasting disease (CWD) is well known among cervids in North America. Nevertheless, management faced different types and degrees of uncertainty when CWD was first detected in reindeer Rangifer tarandus in Nordfjella, Norway in 2016. We present a timeline of the efforts to control CWD, and identify how the process, measurement, environmental, and ...
Atle Mysterud, Michael A. Tranulis, Olav Strand, Christer M. Rolandsen   +3 more
wiley   +1 more source

Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

Animal, 2016
Scrapie is a naturally occurring transmissible spongiform encephalopathy in sheep and goat. It has been known for ~250 years and is characterised by the accumulation of an abnormal isoform of a host-encoded prion protein that leads to progressive ...
L. Curcio, C. Sebastiani, P. Di Lorenzo, E. Lasagna, M. Biagetti   +4 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, Volume 9, Issue 8, August 2025.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

Veterinary Research, 2018
In animal prion diseases, including bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in cervids, and scrapie in sheep and goats, a disease-associated isoform of prion protein (PrPd) accumulates in the brains of affected animals ...
Kohtaro Miyazawa, Kentaro Masujin, Yuichi Matsuura, Yoshifumi Iwamaru, Takashi Yokoyama, Hiroyuki Okada   +5 more
doaj   +1 more source

Animal Industry News, 2009, Vol. 10, no. 1 [PDF]

, 2009
Newsletter produced by Department of Agriculture and Land Stewardship about the animal industry in ...

core  

Genetic Factors Contributing to the Susceptibility of Development of Prion Diseases [PDF]

, 2017
This paper won an honorable mention writing flag award in the research category. Claire Culbertson, writing for Katherine Bruner’s BIO 325L class, “Lab Experience in Genetics”.Bruner, KatherineUndergraduate ...
Culbertson, Claire
core   +1 more source

A Drosophila model of prion disease and its metabolic changes in the brain

Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1347-1363, August 2025.
We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang, Zhixin Sun, Pei Wen, Mengyang Zhao, Yuheng He, Fengting Gou, Jingjing Wang, Qing Fan, Xueyuan Li, Tianying Ma, Xiaoyu Wang, Wen Li, Sen Chen, Deming Zhao, Lifeng Yang   +14 more
wiley   +1 more source

ACAT1, Cav-1, and PrP expression in brains and skin fibroblasts from Sarda breed sheep with scrapie-resistant and scrapie-susceptible genotype. [PDF]

Scrapie is an infective ovine neurodegenerative disease; the only identified component of the infectious agent being an aberrant isoform (PrPSc) of the cellular prion protein (PrPC). So far, no means for ante-mortem diagnosis are available for Scrapie as
Alessandra Pani, Marirosa Putzolu, Claudia Mulas, Cristina D. Orrù, Claudia Abete, Claudia Norfo, M. Dolores Cannas, Sergio Laconi, Paolo La Colla, Sandra Dessì   +9 more
core   +1 more source