Results 111 to 120 of about 29,784 (268)
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]
, 2008 Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano +8 more
core +3 more sources
Endogenous Viral Etiology of Prion Diseases [PDF]
, 2009 Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core +1 more source
Circles and analogies in public health reasoning [PDF]
, 2014 The study of the fallacies has changed almost beyond recognition since Charles Hamblin called for a radical reappraisal of this area of logical inquiry in his 1970 book Fallacies.
Cummings, L
core +1 more source
Partial Copurification of Scrapie-Associated Fibrils and Scrapie Infectivity
Intervirology, 1986 The association between scrapie infectivity and scrapie-associated fibrils (SAF) during a partial purification procedure for infectivity was investigated. Scrapie infectivity and SAF can be separated from most membrane components by subcellular fractionation of infected mouse brain to obtain a synaptosomal fraction, followed by detergent treatment and ...
R A, Somerville, P A, Merz, R I, Carp
openaire +2 more sources
Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222.
Gene, 2012 Scrapie is the transmissible spongiform encephalopathy (TSE) of sheep and goats, and scrapie eradication in sheep is based in part on strong genetic resistance to classical scrapie.
S. White +4 more
semanticscholar +1 more source
PLoS ONE, 2008 BackgroundMost previous analyses of scrapie outbreaks have focused on flocks run by research institutes, which may not reflect the field situation. Within this study, we attempt to rectify this deficit by describing the epidemiological characteristics of
K Marie McIntyre +4 more
doaj +1 more source
Cellular distribution of the prion protein in palatine tonsils of mule deer (Odocoileus hemionus) and Rocky Mountain elk (Cervus elaphus nelsoni) [PDF]
, 2019 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) that affects members of the Cervidae family, including deer (Odocoileus spp.), elk (Cervus Canadensis spp.), and moose (Alces alces spp.).
Belden, E. Lee +2 more
core +1 more source
Changes of Microglial Cells in the Progression of Neurodegeneration in Natural Prion Disease
Frontiers in Bioscience-LandmarkBackground: In recent years, neuroglia has become a therapeutic target for neurodegenerative diseases. Despite the recognition of a variety of microglial morphologies associated with the neuroinflammatory process that involve diverse ...
Marta Monzón +6 more
doaj +1 more source
A survey and a molecular dynamics study on the (central) hydrophobic region of prion proteins
, 2014 Prion diseases are invariably fatal neurodegenerative diseases that affect humans and animals. Unlike most other amyloid forming neurodegenerative diseases, these can be highly infectious. Prion diseases occur in a variety of species.
Wang, Feng, Zhang, Jiapu
core +1 more source
, 2009 In the template-assistance model, normal prion protein (PrPC), the pathogenic cause of prion diseases such as Creutzfeldt-Jakob (CJD) in human, Bovine Spongiform Encephalopathy (BSE) in cow, and scrapie in sheep, converts to infectious prion (PrPSc ...
A Aguzzi +40 more
core +1 more source