Results 121 to 130 of about 29,784 (268)

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

Proceedings of the National Academy of Sciences of the United States of America, 1993
K. Pan, M. Baldwin, J. Nguyen, M. Gasset, A. Serban, D. Groth, I. Mehlhorn, Zehuan Huang, R. Fletterick, F. Cohen   +9 more
semanticscholar   +1 more source

Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration

, 2013
Prion diseases are characterized by accumulation of misfolded protein, gliosis, synaptic dysfunction, and ultimately neuronal loss. This sequence, mirroring key features of Alzheimer disease, is modeled well in ME7 prion disease.
Asuni, Ayodeji A, Bailey, Joanne, Gray, Bryony, O'Connor, Vincent, Perry, V Hugh, Skipp, Paul   +5 more
core   +1 more source

Mice devoid of PrP are resistant to scrapie.

Cell, 1993
H. Büeler, A. Aguzzi, A. Sailer, R. Greiner, P. Autenried, M. Aguet, C. Weissmann   +6 more
semanticscholar   +1 more source

Water and the Biology of Prions and Plaques [PDF]

, 2007
This is an attempt to account for the insolubility and/or aggregation of prions and plaques in terms of a model of water consisting of an equilibrium between high density and low density microdomains.
Graham K. Steel, Phillippa M. Wiggins
core   +1 more source

Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion.

Journal of General Virology, 2016
R. Dassanayake, C. Orrú, A. Hughson, B. Caughey, T. Graça, D. Zhuang, Sally A. Madsen-Bouterse, D. Knowles, D. Schneider   +8 more
semanticscholar   +1 more source

Comparison of Two US Sheep Scrapie Isolates Supports Identification as Separate Strains

Veterinary Pathology-Supplement, 2016
S. J. Moore, Jodi D. Smith, M. Greenlee, E. Nicholson, Juergen A. Richt, J. Greenlee   +5 more
semanticscholar   +1 more source

Scrapie [PDF]

Journal of Comparative Pathology and Therapeutics, 1918
openaire   +3 more sources

Inspecção do sistema nervoso central em pequenos ruminantes

Millenium, 2016
O Scrapie é uma doença neurodegenerativa fatal que afecta ovinos e caprinos e é a forma mais comum das Encefalopatias Espongiformes Transmissíveis (EET's), que incluem a doença de Creutzfeldt – Jakob (CJD), em humanos, e a Encefalopatia Espongiforme ...
Helena Vala, João Mesquita, Fernando Esteves   +2 more
doaj  

Scrapie-resistant sheep show certain coat colour characteristics [PDF]

, 2009
Bell, L., Brotherstone, S., Sawalha, R. M., Villanueva, B., White, I., Wilson, A. J.   +5 more
core   +1 more source

In vitro generation of infectious scrapie prions.

Cell, 2005
J. Castilla, Paula Saá, C. Hetz, C. Soto   +3 more
semanticscholar   +1 more source