Results 101 to 110 of about 29,784 (268)

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease [PDF]

, 2019
Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD).
Dodel, Richard, Du, Eileen, Du, Yansheng, Farlow, Martin R., Gu, Huiying, Kirchhein, Yvonne, Liu, Junyi, Mastrianni, James A., Peng, Hongjun, Zhao, Gang, Zhu, Timothy   +10 more
core   +1 more source

Prion Protein Gene Variability in Spanish Goats. Inference through Susceptibility to Classical Scrapie Strains and Pathogenic Distribution of Peripheral PrPsc

PLoS ONE, 2013
Classical scrapie is a neurological disorder of the central nervous system (CNS) characterized by the accumulation of an abnormal, partially protease resistant prion protein (PrPsc) in the CNS and in some peripheral tissues in domestic small ruminants ...
C. Acín, I. Martín-Burriel, E. Monleón, J. Lyahyai, J. L. Pitarch, C. Serrano, M. Monzón, P. Zaragoza, J. Badiola   +8 more
semanticscholar   +1 more source

The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep

BMC Veterinary Research, 2010
Background Atypical scrapie was first identified in Norwegian sheep in 1998 and has subsequently been identified in many countries. Retrospective studies have identified cases predating the initial identification of this form of scrapie, and ...
Bellworthy Susan J, Thurston Lisa, Konold Timm, Simmons Marion M, Chaplin Melanie J, Moore S   +5 more
doaj   +1 more source

Human α2β1HI CD133+VE epithelial prostate stem cells express low levels of active androgen receptor [PDF]

, 2012
Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated.
A Birgersdotter, Anastasia C. Hepburn, AS Goldstein, AT Collins, AT Collins, C Cai, C Lin, CD Chen, CJ Shepherd, Claudia A. Ryan-Munden, CM van der Loos, Craig N. Robson, D Corbeil, DA Lawson, Deepali Pal, DJ Vander Griend, DM Owens, DT Ross, G Attard, G Buchanan, GD Richardson, GR Cunha, H Bonkhoff, H Bonkhoff, Hing Y. Leung, IV Litvinov, J Perez-Losada, J Yu, JA Kemppainen, JK Blackwood, Kelly Coffey, KG Leong, KM Bae, L Patrawala, Laura Wilson, LE Lamb, MC Haffner, N Platet, NT Gaisa, R Heer, R Heer, Rakesh Heer, S Kolli, S Mousses, SO Lee, Stuart C. Williamson, VK Rajasekhar, X Wang, Yao Liang Tang   +48 more
core   +4 more sources

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

Journal of Biological Chemistry, 1991
A common feature of scrapie and related transmissible spongiform encephalopathies is the accumulation of an abnormal protease-resistant form of PrP which may be the major component of the infectious agent. While it is known that both the normal (protease-
B. Caughey, G. J. Raymond
semanticscholar   +1 more source

The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland

Acta Veterinaria Scandinavica, 2010
Background Previous studies indicated that the iron (Fe)/manganese (Mn) ratio in forage of sheep was significantly higher on scrapie-afflicted farms than on farms in other scrapie categories.
Jóhannesson Torkell, Kristinsson Jakob, Gudmundsdóttir Kristín, Björnsson Hólmgeir, Eiríksson Tryggvi   +4 more
doaj   +1 more source

Targeting of the prion protein to the cytosol: mechanisms and consequences

, 2010
Prion diseases are characterized by the conformational transition of the cellular prion protein (PrPC) into an aberrant protein conformer, designated scrapie-prion protein (PrPSc).
Miesbauer, M., Rambold, A., Tatzelt, J., Winkelhofer, K.   +3 more
core  

Iowa Animal Industry News, 2012, Vol. 14, no. 1 [PDF]

, 2012
Newsletter produced by Department of Agriculture and Land Stewardship about the animal industry in Iowa.Previously titled Animal Industry ...

core  

SCRAPIE

Ankara Üniversitesi Veteriner Fakültesi Dergisi, 1964
Scrapie is a progressive disease of sheep characterised by nervoussymptoms and by a diffuse or focal degeneration of the grey matterof the subcortical centers along the neuroaxis of the central nervoussystem. The disease as far as we are aware is invariably fataL.The clinical symptoms in the shcep consist of incoordination ofgait, trembling and severe ...
openaire   +3 more sources