Results 101 to 110 of about 12,794 (224)

ACAT1, Cav-1, and PrP expression in brains and skin fibroblasts from Sarda breed sheep with scrapie-resistant and scrapie-susceptible genotype.

, 2007
Scrapie is an infective ovine neurodegenerative disease; the only identified component of the infectious agent being an aberrant isoform (PrPSc) of the cellular prion protein (PrPC). So far, no means for ante-mortem diagnosis are available for Scrapie as
Claudia Abete, Claudia Mulas, Marirosa Putzolu, Cristina D. Orrù, Sandra Dessì, Alessandra Pani, Paolo La Colla, Sergio Laconi, Claudia Norfo, M. Dolores Cannas   +9 more
core  

Epidemiological characteristics of classical scrapie outbreaks in 30 sheep flocks in the United Kingdom.

PLoS ONE, 2008
BackgroundMost previous analyses of scrapie outbreaks have focused on flocks run by research institutes, which may not reflect the field situation. Within this study, we attempt to rectify this deficit by describing the epidemiological characteristics of
K Marie McIntyre, Simon Gubbins, Wilfred Goldmann, Nora Hunter, Matthew Baylis   +4 more
doaj   +1 more source

The 37kDa/67kDa laminin receptor as a therapeutic target in prion diseases: potency of antisense LRP RNA, siRNAs specific for LRP mRNA and a LRP decoy mutant [PDF]

, 2006
Prion diseases are a group of rare, fatal neurodegenerative diseases, also known as transmissible spongiform encephalopathies (TSEs), that affect both animals and humans and include bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep ...
Vana, Karen
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High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age

, 2009
The factors influencing the microstructure of fresh cheese, particularly the particle size, and its reduction by mechanical post-processing, were studied.
Saunders, Ginny, Windl, O., Stuart Martin, Phelan, Laura, Dawson, Michael, Angel Ortiz-Peláez, Timm Konold, Laura Phelan, Martin, Stuart, Hope, James, Ortiz-Pelaez, A., Jeffrey, M., Michael Dawson, Ginny Saunders, Sisó, Sílvia, Dawson, M., James Hope, Stephen A.C. Hawkins, Siso, S., Paula Stewart, Hope, J., Lorenzo González, Wilfred Goldmann, Martin Jeffrey, Phelan, L., Goldmann, W., Martin, S., González, Lorenzo, Goldmann, Wilfred, Windl, Otto, Konold, T., Hawkins, S. A., Saunders, G., Sílvia Sisó, Stewart, Paula, Stewart, P., Gonzalez, L., Otto Windl, Jeffrey, Martin, Konold, Timm, Ortiz-Peláez, Angel, Hawkins, Stephen A.C.   +41 more
core   +1 more source

Characterization of the prion protein in relation to normal cellular function and in disease [PDF]

, 2012
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare and fatal neurodegenerative disorders that can affect both human and animals.
Wik, Lotta
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Changes of Microglial Cells in the Progression of Neurodegeneration in Natural Prion Disease

Frontiers in Bioscience-Landmark
Background: In recent years, neuroglia has become a therapeutic target for neurodegenerative diseases. Despite the recognition of a variety of microglial morphologies associated with the neuroinflammatory process that involve diverse ...
Marta Monzón, Juan Sauca Pérez, Rodrigo S. Hernández, Rocío Sarasa, Moisés Garcés, M José Luesma, Juan J Badiola   +6 more
doaj   +1 more source

Scrapie-infected brain homogenate causes PrP^C-dependent loss of dendritic spines.

, 2016
Primary hippocampal neurons from wild-type (WT) mice (A-F) or PrP knockout (Prn-p0/0) mice (G-J) were treated for 24 hr with brain homogenate (0.16% [w/v] final concentration) prepared from either normal mice (NBH) (A-C, G, I) or from terminally ill ...
David A. Harris (330039), Cheng Fang (611972), Maria Carmen Garza (2808418), Thibaut Imberdis (667337), Holger Wille (190809)   +4 more
core   +1 more source

MRI assessment of the blood-brain barrier in a hamster model of scrapie

, 1995
Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of ...
Williams, S.C.R., Cox, I.J., Williams, A., Beech, J.S., Bell, J.D., Hope, J., Chung, Y.L.   +6 more
core   +1 more source

Proteins as markers of TSE infection in sheep blood

, 2008
Transmissible spongiform encephalopathies (TSEs) are a group of fatal infectious neurodegenerative diseases affecting both humans and agricultural animals. TSE transmission via blood transfusion has been demonstrated experimentally in rodent, primate and
Martin, Joanne
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Atypical scrapie in a Swiss goat and implications for transmissible spongiform encephalopathy surveillance

, 2007
Different types of transmissible spongiform encephalopathies (TSEs) affect sheep and goats. In addition to the classical form of scrapie, both species are susceptible to experimental infections with the bovine spongiform encephalopathy (BSE) agent, and ...
Seuberlich, Torsten, Martina Friess, Zurbriggen, Andreas, Wyss, Reto, Brünisholz, Hervé, Nicolier, Alexandra, Kihm, Ulrich, Benestad, Sylvie L, Sylvie L. Benestad, Dagmar Heim, Andreas Zurbriggen, Heinzpeter Schwermer, Hervé Brünisholz, Botteron, Catherine, Friess, Martina, Heim, Dagmar, Catherine Botteron, Ulrich Kihm, Torsten Seuberlich, Schwermer, Heinzpeter, Alexandra Nicolier, Reto Wyss   +21 more
core   +1 more source