Results 91 to 100 of about 12,794 (224)

Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon

, 1991
Current models of the virus-like agents of scrapie and bovine spongiform encephalopathy (BSE) have to take into account that structural changes in a host-encoded protein (PrP protein) exhibit an effect on the time course of these diseases and the ...
Dawson, M, Hunter, N., Martin, T., Hunter, N, Goldmann, W., Goldmann, W, Dawson, M., Hope, J, Hope, J., Martin, T   +9 more
core   +1 more source

Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds

BMC Veterinary Research, 2020
Background Classical scrapie susceptibility in sheep has been linked to three polymorphisms at codon 136, 154, and 171 in the prion protein gene (PRNP) whereas atypical scrapie susceptibility is related to polymorphisms at codon 141.
Eden Yitna Teferedegn, Yalcin Yaman, Cemal Un   +2 more
doaj   +1 more source

Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scarpie strains within Europe

, 2010
Variability of pathological phenotypes within classical sheep scrapie cases has been reported for some time, but in many instances it has been attributed to differences in the PRNP genotype of the host.
González, L., E. Monleon, L. J. M. van Keulen, Jeffrey, M., Balkema-Buschmann, A., C. Hoffmann, Badiola, J.J., Lulini, B., Keulen, L.J.M., van, van Keulen, L.J.M., A. Balkema-Buschmann, Monleón, E., S. Siso, A. Ortiz-Pelaez, Langeveld, J.P.M., Hoffmann, C., J. J. Badiola, Sisó, S., Acín, C., Ortiz-Peláez, A., J. P. M. Langeveld, B. Iulini, M. Jeffrey, L. Gonzalez, C. Casalone, Casalone, C., C. Acin   +26 more
core   +1 more source

The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep

BMC Veterinary Research, 2010
Background Atypical scrapie was first identified in Norwegian sheep in 1998 and has subsequently been identified in many countries. Retrospective studies have identified cases predating the initial identification of this form of scrapie, and ...
Bellworthy Susan J, Thurston Lisa, Konold Timm, Simmons Marion M, Chaplin Melanie J, Moore S   +5 more
doaj   +1 more source

PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer

, 2002
Up to 15% of free-ranging mule deer in northeastern Colorado and southeastern Wyoming, USA, are afflicted with a prion disease, or transmissible spongiform encephalopathy (TSE), known as chronic wasting disease (CWD).
Keulen, L.J.M., van, van Keulen, L.J.M., Miller, M.W., Oesch, B., Hoover, E.A., Langeveld, J.P.M., Sigurdson, C.J., Barillas-Mury, C.   +7 more
core   +1 more source

The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland

Acta Veterinaria Scandinavica, 2010
Background Previous studies indicated that the iron (Fe)/manganese (Mn) ratio in forage of sheep was significantly higher on scrapie-afflicted farms than on farms in other scrapie categories.
Jóhannesson Torkell, Kristinsson Jakob, Gudmundsdóttir Kristín, Björnsson Hólmgeir, Eiríksson Tryggvi   +4 more
doaj   +1 more source

Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene

Veterinary Research, 2012
Susceptibility of sheep to scrapie, a transmissible spongiform encephalopathy of small ruminants, is strongly influenced by polymorphisms of the prion protein gene (PRNP).
Acutis Pier Luigi, Martucci Francesca, D'Angelo Antonio, Peletto Simone, Colussi Silvia, Maurella Cristiana, Porcario Chiara, Iulini Barbara, Mazza Maria, Dell'Atti Luana, Zuccon Fabio, Corona Cristiano, Martinelli Nicola, Casalone Cristina, Caramelli Maria, Lombardi Guerino   +15 more
doaj   +1 more source

Partial Copurification of Scrapie-Associated Fibrils and Scrapie Infectivity

Intervirology, 1986
The association between scrapie infectivity and scrapie-associated fibrils (SAF) during a partial purification procedure for infectivity was investigated. Scrapie infectivity and SAF can be separated from most membrane components by subcellular fractionation of infected mouse brain to obtain a synaptosomal fraction, followed by detergent treatment and ...
R A, Somerville, P A, Merz, R I, Carp
openaire   +2 more sources

Small critical RNAs in the scrapie agent

, 2009
Unconventional infectious agents cause transmissible spongiform encephalopathy (TSE) diseases including scrapie and bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease in humans. The protein only hypothesis claims that the TSE
Marie-Madeleine Ruchoux, Jean-Philippe Deslys, Nicolas Vignier, Pierre Lebon, Jean-Guy Fournier, Sophie Freire, Emmanuel Comoy, Steve Simoneau   +7 more
core  

SCRAPIE

Ankara Üniversitesi Veteriner Fakültesi Dergisi, 1964
Scrapie is a progressive disease of sheep characterised by nervoussymptoms and by a diffuse or focal degeneration of the grey matterof the subcortical centers along the neuroaxis of the central nervoussystem. The disease as far as we are aware is invariably fataL.The clinical symptoms in the shcep consist of incoordination ofgait, trembling and severe ...
openaire   +3 more sources