Results 71 to 80 of about 16,279 (223)

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds

BMC Veterinary Research, 2020
Background Classical scrapie susceptibility in sheep has been linked to three polymorphisms at codon 136, 154, and 171 in the prion protein gene (PRNP) whereas atypical scrapie susceptibility is related to polymorphisms at codon 141.
Eden Yitna Teferedegn, Yalcin Yaman, Cemal Un   +2 more
doaj   +1 more source

Prion Protein Gene Variability in Spanish Goats. Inference through Susceptibility to Classical Scrapie Strains and Pathogenic Distribution of Peripheral PrPsc

PLoS ONE, 2013
Classical scrapie is a neurological disorder of the central nervous system (CNS) characterized by the accumulation of an abnormal, partially protease resistant prion protein (PrPsc) in the CNS and in some peripheral tissues in domestic small ruminants ...
C. Acín, I. Martín-Burriel, E. Monleón, J. Lyahyai, J. Pitarch, C. Serrano, M. Monzón, P. Zaragoza, J. Badiola   +8 more
semanticscholar   +1 more source

Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer, Lea T. Grinberg, Jared T. Ahrendsen, Thomas G. Beach, Kevin F. Bieniek, Rudolph J. Castellani, Rati Chkheidze, Inma Cobos, Mark Cohen, John F. Crary, Dennis W. Dickson, Brittany N. Dugger, Sara R. Dunlop, Kurt Farrell, Bernardino Ghetti, Mohammad Haeri, William Harrison, Elizabeth Head, Annie Hiniker, Eric J. Huang, Anita Huttner, Pouya Jamshidi, Alifiya Kapasi, C. Dirk Keene, Julia Kofler, Caitlin S. Latimer, Ann C. McKee, Karin Mente, Michael B. Miller, Thomas J. Montine, Meaghan Morris, Melissa E. Murray, Peter T. Nelson, Kathy L. Newell, Richard J. Perrin, Biswarathan Ramani, R. Ross Reichard, Subhojit Roy, Johannes C. M. Schlachetzki, William W. Seeley, Geidy E. Serrano, Salvatore Spina, Andrew F. Teich, Shih‐Hsiu J. Wang, Thomas Wisniewski, Edward B. Lee   +45 more
wiley   +1 more source

Evidence of effective scrapie transmission via colostrum and milk in sheep

BMC Veterinary Research, 2013
BackgroundEvidence for scrapie transmission from VRQ/VRQ ewes to lambs via milk was first reported in 2008 but in that study there were concerns that lateral transmission may have contributed to the high transmission rate observed since five control ...
T. Konold, S. J. Moore, S. J. Moore, S. Bellworthy, L. Terry, L. Thorne, Andrew M. Ramsay, Francisco J. Salguero, M. Simmons, H. Simmons   +9 more
semanticscholar   +1 more source

The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland

Acta Veterinaria Scandinavica, 2010
Background Previous studies indicated that the iron (Fe)/manganese (Mn) ratio in forage of sheep was significantly higher on scrapie-afflicted farms than on farms in other scrapie categories.
Jóhannesson Torkell, Kristinsson Jakob, Gudmundsdóttir Kristín, Björnsson Hólmgeir, Eiríksson Tryggvi   +4 more
doaj   +1 more source

The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep

BMC Veterinary Research, 2010
Background Atypical scrapie was first identified in Norwegian sheep in 1998 and has subsequently been identified in many countries. Retrospective studies have identified cases predating the initial identification of this form of scrapie, and ...
Bellworthy Susan J, Thurston Lisa, Konold Timm, Simmons Marion M, Chaplin Melanie J, Moore S   +5 more
doaj   +1 more source

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

Journal of Biological Chemistry, 1991
A common feature of scrapie and related transmissible spongiform encephalopathies is the accumulation of an abnormal protease-resistant form of PrP which may be the major component of the infectious agent. While it is known that both the normal (protease-
B. Caughey, G. J. Raymond
semanticscholar   +1 more source

Partial Copurification of Scrapie-Associated Fibrils and Scrapie Infectivity

Intervirology, 1986
The association between scrapie infectivity and scrapie-associated fibrils (SAF) during a partial purification procedure for infectivity was investigated. Scrapie infectivity and SAF can be separated from most membrane components by subcellular fractionation of infected mouse brain to obtain a synaptosomal fraction, followed by detergent treatment and ...
R A, Somerville, P A, Merz, R I, Carp
openaire   +2 more sources

Japanese Scrapie Cases

Japanese Journal of Infectious Diseases, 2000
Worldwide attention has been given to scrapie, because bovine spongiform encephalopathy (BSE) could be experimentally transmitted to sheep. This ovine form of BSE was clinically identical to scrapie. In Japanese scrapie cases, a majority of the diseased sheep were from Suffolk, while 8 cases were from Corriedale.
Onodera, Takashi, Saeki, Keiichi
openaire   +2 more sources