Results 71 to 80 of about 12,794 (224)

Prion protein self-peptides modulate prion interactions and conversion [PDF]

, 2009
Background: Molecular mechanisms underlying prion agent replication, converting host-encoded cellular prion protein (PrPC) into the scrapie associated isoform (PrPSc), are poorly understood.
Bossers, A., Fred G van Zijderveld, Priem, J., Drophatie Timmers-Parohi, Rigter, A., Alex Bossers, Alan Rigter, Timmers-Parohi, D., Jan PM Langeveld, van Zijderveld, F.G., Zijderveld, F.G., van, Jan Priem, Langeveld, J.P.M.   +12 more
core   +1 more source

Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

Animal, 2016
Scrapie is a naturally occurring transmissible spongiform encephalopathy in sheep and goat. It has been known for ~250 years and is characterised by the accumulation of an abnormal isoform of a host-encoded prion protein that leads to progressive ...
L. Curcio, C. Sebastiani, P. Di Lorenzo, E. Lasagna, M. Biagetti   +4 more
doaj   +1 more source

Epigenetic Modifications Influence Reproductive Traits in Small Ruminants

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
The epigenome undergoes dynamic changes shaped by the intricate interplay of genetic and environmental factors, which are crucial for individual growth and development. Recent studies suggest that factors such as nutrition, thermal stress (TS), infections, and assisted reproductive technologies (ARTs) can influence epigenetic changes in small ruminants
Galma Boneya Arero, Ozge Ozmen, Lipi Buch   +2 more
wiley   +1 more source

Neurofilaments in blood is a new promising preclinical biomarker for the screening of natural scrapie in sheep.

PLoS ONE, 2019
Scrapie is a fatal neurodegenerative disease of sheep and goats belonging to the group of Transmissible Spongiform Encephalopathy or prion diseases. The EU has adopted mandatory measures for scrapie surveillance to safeguard public and animal health ...
Henrik Zetterberg, Elena Bozzetta, Alessandra Favole, Cristiano Corona, Maria Concetta Cavarretta, Francesco Ingravalle, Kaj Blennow, Maurizio Pocchiari, Daniela Meloni   +8 more
doaj   +1 more source

Advice on animal and public health risks of insects reared on former foodstuffs as raw material for animal feed

Food Risk Assess Europe, Volume 4, Issue 1, January 2026.
Abstract In the coming decades, there is expected to be a sharply increased demand for dietary proteins for humans and animals. As a result, there is an increasing focus on reared insects as a new source of protein. According to the Ministry of Agriculture, Nature and Food Quality (LNV), the use of food chain residual flows such as former foodstuffs as
L.F.F. Kox, D.T.H.M. Sijm
wiley   +1 more source

A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrPres

, 2006
Prion diseases are associated with the conversion of the normal cellular prion protein, PrPC, to the abnormal, disease-associated form, PrPSc. This conversion can be mimicked in vitro by using a cell-free conversion assay. It has recently been shown that
Kirby, Louise, Manson, Jean C., Houston, Fiona, Goldmann, Wilfred, Gill, Andrew C.   +4 more
core   +1 more source

Atypical/Nor98 scrapie infectivity in sheep peripheral tissues. [PDF]

PLoS Pathogens, 2011
Atypical/Nor98 scrapie was first identified in 1998 in Norway. It is now considered as a worldwide disease of small ruminants and currently represents a significant part of the detected transmissible spongiform encephalopathies (TSE) cases in Europe ...
Olivier Andréoletti, Leonor Orge, Sylvie L Benestad, Vincent Beringue, Claire Litaise, Stéphanie Simon, Annick Le Dur, Hubert Laude, Hugh Simmons, Séverine Lugan, Fabien Corbière, Pierrette Costes, Nathalie Morel, François Schelcher, Caroline Lacroux   +14 more
doaj   +1 more source

Crosstalk Between Cancer‐Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer‐associated fibroblasts (CAFs) are widely engaged in tumor progression in the tumor microenvironment. CAFs interact actively with immunocytes including tumor‐associated macrophages, T cells, neutrophils, and NK cells in a positive‐feedback loop to sculpt tumor immune microenvironment and participate in tumor activities and antitumor therapy ...
Ya Li, Xingpeng Di, Jiawei Chen, Jingwen Wei, Tianyue Li, Kunjie Wang, Banghua Liao, Deyi Luo   +7 more
wiley   +1 more source

TSE pathogenesis in cattle and sheep

, 2008
Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts ...
Bossers, A., Fred van Zijderveld, Lucien J.M. van Keulen, van Zijderveld, Fred, Keulen, L.J.M., van, van Keulen, L.J.M., van Zijderveld, F.G., Zijderveld, F.G., van, Bossers, Alex, van Keulen, Lucien, Alex Bossers   +10 more
core   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source