Results 61 to 70 of about 8,594 (178)

Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds

open access: yesBMC Veterinary Research, 2020
Background Classical scrapie susceptibility in sheep has been linked to three polymorphisms at codon 136, 154, and 171 in the prion protein gene (PRNP) whereas atypical scrapie susceptibility is related to polymorphisms at codon 141.
Eden Yitna Teferedegn   +2 more
doaj   +1 more source

Epigenetic Modifications Influence Reproductive Traits in Small Ruminants

open access: yesVeterinary Medicine International, Volume 2026, Issue 1, 2026.
The epigenome undergoes dynamic changes shaped by the intricate interplay of genetic and environmental factors, which are crucial for individual growth and development. Recent studies suggest that factors such as nutrition, thermal stress (TS), infections, and assisted reproductive technologies (ARTs) can influence epigenetic changes in small ruminants
Galma Boneya Arero   +2 more
wiley   +1 more source

Advice on animal and public health risks of insects reared on former foodstuffs as raw material for animal feed

open access: yesFood Risk Assess Europe, Volume 4, Issue 1, January 2026.
Abstract In the coming decades, there is expected to be a sharply increased demand for dietary proteins for humans and animals. As a result, there is an increasing focus on reared insects as a new source of protein. According to the Ministry of Agriculture, Nature and Food Quality (LNV), the use of food chain residual flows such as former foodstuffs as
L.F.F. Kox, D.T.H.M. Sijm
wiley   +1 more source

Crosstalk Between Cancer‐Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications

open access: yesMedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer‐associated fibroblasts (CAFs) are widely engaged in tumor progression in the tumor microenvironment. CAFs interact actively with immunocytes including tumor‐associated macrophages, T cells, neutrophils, and NK cells in a positive‐feedback loop to sculpt tumor immune microenvironment and participate in tumor activities and antitumor therapy ...
Ya Li   +7 more
wiley   +1 more source

The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland

open access: yesActa Veterinaria Scandinavica, 2010
Background Previous studies indicated that the iron (Fe)/manganese (Mn) ratio in forage of sheep was significantly higher on scrapie-afflicted farms than on farms in other scrapie categories.
Jóhannesson Torkell   +4 more
doaj   +1 more source

The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep

open access: yesBMC Veterinary Research, 2010
Background Atypical scrapie was first identified in Norwegian sheep in 1998 and has subsequently been identified in many countries. Retrospective studies have identified cases predating the initial identification of this form of scrapie, and ...
Bellworthy Susan J   +5 more
doaj   +1 more source

Partial Copurification of Scrapie-Associated Fibrils and Scrapie Infectivity

open access: yesIntervirology, 1986
The association between scrapie infectivity and scrapie-associated fibrils (SAF) during a partial purification procedure for infectivity was investigated. Scrapie infectivity and SAF can be separated from most membrane components by subcellular fractionation of infected mouse brain to obtain a synaptosomal fraction, followed by detergent treatment and ...
R A, Somerville, P A, Merz, R I, Carp
openaire   +2 more sources

Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene

open access: yesVeterinary Research, 2012
Susceptibility of sheep to scrapie, a transmissible spongiform encephalopathy of small ruminants, is strongly influenced by polymorphisms of the prion protein gene (PRNP).
Acutis Pier Luigi   +15 more
doaj   +1 more source

SCRAPIE

open access: yesAnkara Üniversitesi Veteriner Fakültesi Dergisi, 1964
Scrapie is a progressive disease of sheep characterised by nervoussymptoms and by a diffuse or focal degeneration of the grey matterof the subcortical centers along the neuroaxis of the central nervoussystem. The disease as far as we are aware is invariably fataL.The clinical symptoms in the shcep consist of incoordination ofgait, trembling and severe ...
openaire   +3 more sources

Changes of Microglial Cells in the Progression of Neurodegeneration in Natural Prion Disease

open access: yesFrontiers in Bioscience-Landmark
Background: In recent years, neuroglia has become a therapeutic target for neurodegenerative diseases. Despite the recognition of a variety of microglial morphologies associated with the neuroinflammatory process that involve diverse ...
Marta Monzón   +6 more
doaj   +1 more source

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