Results 41 to 50 of about 12,794 (224)
Evidence in sheep for pre-natal transmission of scrapie to lambs from infected mothers.
PLoS ONE, 2013 Natural scrapie transmission from infected ewes to their lambs is thought to occur by the oral route around the time of birth. However the hypothesis that scrapie transmission can also occur before birth (in utero) is not currently favoured by most ...
James D Foster +2 more
doaj +1 more source
PLoS ONE, 2011 The possibility of the agent causing bovine spongiform encephalopathy (BSE) infecting small ruminants is of serious concern for human health. Among scrapie cases, the CH1641 source in particular appears to have certain biochemical properties similar to ...
Anna Bencsik, Thierry Baron
doaj +1 more source
The limits of test-based scrapie eradication programs in goats. [PDF]
PLoS ONE, 2013 Small ruminant post-mortem testing programs were initially designed for monitoring the prevalence of prion disease. They are now considered as a potential alternative to genetic selection for eradicating/controlling classical scrapie at population level.
Fabien Corbière +10 more
doaj +1 more source
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, EarlyView.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure
, 2005 The accumulation of the scrapie agent in lymphoid tissues following inoculation via the skin is critical for efficient neuroinvasion, but how the agent is initially transported from the skin to the draining lymph node is not known. Langerhans cells (LCs)
Hopkins, John +5 more
core +1 more source
Evidence of scrapie transmission via milk
BMC Veterinary Research, 2008 Background The risk of scrapie infection increases with increased duration and proximity of contact between sheep at lambing. Scrapie infectivity has not been detected in milk but cellular prion protein, the precursor of disease-associated prion protein ...
Moore S Jo +3 more
doaj +1 more source
PLoS Pathogens, 2023 Prion agents occur in strains that are encoded by the structure of the misfolded prion protein (PrPSc). Prion strains can influence disease phenotype and the potential for interspecies transmission.
Robyn D Kokemuller +4 more
doaj +1 more source
HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone +2 more
wiley +1 more source
Genotyping and surveillance for scrapie in Finnish sheep
BMC Veterinary Research, 2012 Background The progression of scrapie is known to be influenced by the amino acid polymorphisms of the host prion protein (PrP) gene. There is no breeding programme for TSE resistance in sheep in Finland, but a scrapie control programme has been in place
Hautaniemi Maria +3 more
doaj +1 more source
Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie
Scientific Reports, 2021 Pigs are susceptible to infection with the classical bovine spongiform encephalopathy (C-BSE) agent following experimental inoculation, and PrPSc accumulation was detected in porcine tissues after the inoculation of certain scrapie and chronic wasting ...
Belén Marín +12 more
doaj +1 more source