Results 41 to 50 of about 16,279 (223)
PLoS Pathogens, 2023 Prion agents occur in strains that are encoded by the structure of the misfolded prion protein (PrPSc). Prion strains can influence disease phenotype and the potential for interspecies transmission.
Robyn D Kokemuller +4 more
doaj +1 more source
The Exceptions to the Central Dogma of Biology—Bending the Rules and Extending the Scope
Natural Sciences, Volume 6, Issue 4, October 2026.ABSTRACT The central dogma is an organizing framework for how information flows in biological systems. First presented in 1957 by Francis Crick in his talk “On Protein Synthesis” as a fundamental hypothesis of how information is transferred from DNA to proteins but not out of proteins, it is now introduced in cell biology textbooks as three sequential ...
Anat Ben‐Zvi
wiley +1 more source
Evidence of scrapie transmission via milk
BMC Veterinary Research, 2008 Background The risk of scrapie infection increases with increased duration and proximity of contact between sheep at lambing. Scrapie infectivity has not been detected in milk but cellular prion protein, the precursor of disease-associated prion protein ...
Moore S Jo +3 more
doaj +1 more source
Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie
Scientific Reports, 2021 Pigs are susceptible to infection with the classical bovine spongiform encephalopathy (C-BSE) agent following experimental inoculation, and PrPSc accumulation was detected in porcine tissues after the inoculation of certain scrapie and chronic wasting ...
Belén Marín +12 more
doaj +1 more source
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, Volume 13, Issue 40, 17 July 2026.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
Genotyping and surveillance for scrapie in Finnish sheep
BMC Veterinary Research, 2012 Background The progression of scrapie is known to be influenced by the amino acid polymorphisms of the host prion protein (PrP) gene. There is no breeding programme for TSE resistance in sheep in Finland, but a scrapie control programme has been in place
Hautaniemi Maria +3 more
doaj +1 more source
The limits of test-based scrapie eradication programs in goats. [PDF]
PLoS ONE, 2013 Small ruminant post-mortem testing programs were initially designed for monitoring the prevalence of prion disease. They are now considered as a potential alternative to genetic selection for eradicating/controlling classical scrapie at population level.
Fabien Corbière +10 more
doaj +1 more source
Incidence of infection in Prnp ARR/ARR sheep following experimental inoculation with or natural exposure to classical scrapie. [PDF]
PLoS ONE, 2014 The prion protein gene (Prnp) is highly influential in determining risk and susceptibility of sheep exposed to classical scrapie. Sheep homozygous for alanine at codon 136 and arginine at codons 154 and 171 (ARR/ARR) of the Prnp gene are historically ...
Martin Jeffrey +5 more
doaj +1 more source
HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone +2 more
wiley +1 more source