Results 41 to 50 of about 29,784 (268)

Diversity in neuroanatomical distribution of abnormal prion protein in atypical scrapie.

PLoS Pathogens, 2007
Scrapie is a transmissible spongiform encephalopathy (TSE) in sheep and goats. In recent years, atypical scrapie cases were identified that differed from classical scrapie in the molecular characteristics of the disease-associated pathological prion ...
Alice Nentwig, Anna Oevermann, Dagmar Heim, Catherine Botteron, Karola Zellweger, Cord Drögemüller, Andreas Zurbriggen, Torsten Seuberlich   +7 more
doaj   +1 more source

Transmission of scrapie prions to primate after an extended silent incubation period

Scientific Reports, 2015
Classical bovine spongiform encephalopathy (c-BSE) is the only animal prion disease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having guided protective measures for animal and human health against animal prion ...
E. Comoy, J. Mikol, Sophie Luccantoni-Freire, E. Correia, Nathalie Lescoutra-etchegaray, V. Durand, C. Dehen, O. Andréoletti, C. Casalone, J. Richt, J. Greenlee, T. Baron, S. Benestad, P. Brown, J. Deslys   +14 more
semanticscholar   +1 more source

Implications of conflicting associations of the prion protein (PrP) gene with scrapie susceptibility and fitness on the persistence of scrapie.

PLoS ONE, 2009
BackgroundExisting mathematical models for scrapie dynamics in sheep populations assume that the PrP gene is only associated with scrapie susceptibility and with no other fitness related traits.
Andrea Doeschl-Wilson, Rami Sawalha, Simon Gubbins, Beatriz Villanueva   +3 more
doaj   +1 more source

Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scarpie strains within Europe [PDF]

, 2010
Variability of pathological phenotypes within classical sheep scrapie cases has been reported for some time, but in many instances it has been attributed to differences in the PRNP genotype of the host.
Acín, C., Badiola, J.J., Balkema-Buschmann, A., Casalone, C., González, L., Hoffmann, C., Jeffrey, M., Keulen, L.J.M., van, Langeveld, J.P.M., Lulini, B., Monleón, E., Ortiz-Peláez, A., Sisó, S.   +12 more
core   +2 more sources

Scrapie versus Chronic Wasting Disease in White-Tailed Deer

Emerging Infectious Diseases
White-tailed deer are susceptible to scrapie (WTD scrapie) after oronasal inoculation with the classical scrapie agent from sheep. Deer affected by WTD scrapie are difficult to differentiate from deer infected with chronic wasting disease (CWD).
Zoe J. Lambert, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, Justin J. Greenlee   +4 more
doaj   +1 more source

Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance

BMC Veterinary Research, 2010
Background Susceptibility of sheep to scrapie infection is known to be modulated by the PrP genotype of the animal. In the Netherlands an ambitious scrapie control programme was started in 1998, based on genetic selection of animals for breeding.
Engel Bas, Davidse Aart, Bossers Alex, Melchior Marielle B, Hagenaars Thomas J, van Zijderveld Fred G   +5 more
doaj   +1 more source

Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (bse) and scrapie in Great Britain [PDF]

, 2017
Transmissible spongiform encephalopathies (TSEs) are an important public health concern. Since the emergence of bovine spongiform encephalopathy (BSE) during the 1980s and its link with human Creutzfeldt- Jakob disease, active surveillance has been a key
Arnold, Arnold, Arnold, Boqvist, Cassard, Comoy, Del Rio Vilas, Detwiler, Gafni, Garber, Gill, Gubbins, Maheshwari, McCabe, Prattley, Wells, Wilesmith   +16 more
core   +3 more sources

The placenta shed from goats with classical scrapie is infectious to goat kids and lambs

Journal of General Virology, 2015
The placenta of domestic sheep plays a key role in horizontal transmission of classical scrapie. Domestic goats are frequently raised with sheep and are susceptible to classical scrapie, yet potential routes of transmission from goats to sheep are not ...
D. Schneider, Sally A. Madsen-Bouterse, D. Zhuang, T. Truscott, R. Dassanayake, K. O'Rourke   +5 more
semanticscholar   +1 more source

Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype. [PDF]

PLoS ONE, 2009
Atypical scrapie or Nor98 has been identified as a transmissible spongiform encephalopathy (TSE) that is clearly distinguishable from classical scrapie and BSE, notably regarding the biochemical features of the protease-resistant prion protein PrP(res ...
Jean-Noël Arsac, Dominique Bétemps, Eric Morignat, Cécile Féraudet, Anna Bencsik, Denise Aubert, Jacques Grassi, Thierry Baron   +7 more
doaj   +1 more source

Genetic Diversity in Dutch Sheep Breeds

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT The Netherlands has a rich variety of native sheep breeds, most of them at risk or endangered. We studied the distinctiveness of these breeds, their genetic diversity within and between breeds, and how this diversity is shaped by geography, purpose, history and genetic management practices.
J. Noëlle Hoorneman, Mira A. Schoon, Richard P. M. A. Crooijmans, Sipke Joost Hiemstra, Jack J. Windig   +4 more
wiley   +1 more source