Results 51 to 60 of about 8,594 (178)

Scrapie-Associated Tubulofilamentous Particles in Scrapie Hamsters

Intervirology, 1992
Examination of thin sections from the cerebral cortex of scrapie-infected hamster brains revealed characteristic circular 26-30 nm diameter tubulofilamentous particles, identical to those previously described in both experimentally induced scrapie in mice, hamsters and natural scrapie of sheep, bovine spongiform encephalopathy and human Creutzfeldt ...
openaire   +2 more sources

Genetic Diversity in Dutch Sheep Breeds

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT The Netherlands has a rich variety of native sheep breeds, most of them at risk or endangered. We studied the distinctiveness of these breeds, their genetic diversity within and between breeds, and how this diversity is shaped by geography, purpose, history and genetic management practices.
J. Noëlle Hoorneman, Mira A. Schoon, Richard P. M. A. Crooijmans, Sipke Joost Hiemstra, Jack J. Windig   +4 more
wiley   +1 more source

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, Volume 99, Issue 4, Page 897-911, April 2026.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Neurofilaments in blood is a new promising preclinical biomarker for the screening of natural scrapie in sheep.

PLoS ONE, 2019
Scrapie is a fatal neurodegenerative disease of sheep and goats belonging to the group of Transmissible Spongiform Encephalopathy or prion diseases. The EU has adopted mandatory measures for scrapie surveillance to safeguard public and animal health ...
Henrik Zetterberg, Elena Bozzetta, Alessandra Favole, Cristiano Corona, Maria Concetta Cavarretta, Francesco Ingravalle, Kaj Blennow, Maurizio Pocchiari, Daniela Meloni   +8 more
doaj   +1 more source

Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

Animal, 2016
Scrapie is a naturally occurring transmissible spongiform encephalopathy in sheep and goat. It has been known for ~250 years and is characterised by the accumulation of an abnormal isoform of a host-encoded prion protein that leads to progressive ...
L. Curcio, C. Sebastiani, P. Di Lorenzo, E. Lasagna, M. Biagetti   +4 more
doaj   +1 more source

Lambs with scrapie susceptible genotypes have higher postnatal survival. [PDF]

PLoS ONE, 2007
BACKGROUND: Prion protein (PrP) alleles associated with scrapie susceptibility persist in many sheep populations even with high frequencies despite centuries of selection against them.
Rami M Sawalha, Susan Brotherstone, Joanne Conington, Beatriz Villanueva   +3 more
doaj   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, Volume 39, Issue 3, Page 346-367, April 2026.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

Veterinary Research, 2018
In animal prion diseases, including bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in cervids, and scrapie in sheep and goats, a disease-associated isoform of prion protein (PrPd) accumulates in the brains of affected animals ...
Kohtaro Miyazawa, Kentaro Masujin, Yuichi Matsuura, Yoshifumi Iwamaru, Takashi Yokoyama, Hiroyuki Okada   +5 more
doaj   +1 more source

Possible alignment of the EU BSE surveillance with the new WOAH provisions

EFSA Journal, Volume 24, Issue 4, April 2026.
Abstract The European Commission requested the assessment of the capacity of the surveillance provisions of the World Organization for Animal Health (WOAH) to detect bovine spongiform encephalopathy (BSE) cases (C‐, H‐ and L‐type) in the European Union (EU) and to propose if any current EU surveillance provisions should be kept.
EFSA Panel on Animal Health and Welfare (AHAW), Søren Saxmose Nielsen, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Angel Miranda Chueca, Eleonora Nannoni, Anja B. Riber, Karl Stahl, Jan Arend Stegeman, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Mark Arnold, Christian Ducrot, John Griffin, Giuseppe Ru, Marion Simmons, Sean Ashe, Angel Ortiz‐ Pelaez, Kamela Kryemadhi, Romolo Nonno   +25 more
wiley   +1 more source

Optimising the Use of Cryopreserved Genetic Resources for the Selection and Conservation of Animal Populations

Journal of Animal Breeding and Genetics, Volume 143, Issue 1, Page 50-67, January 2026.
ABSTRACT Genetic diversity is essential for the sustainability and adaptability of populations, and is thus a central pillar of the agro‐ecological transition. However, within a population, it is inevitable that some amount of genetic variability is lost, and efforts must be made to limit this as much as possible.
Alicia Jacques, Michèle Tixier‐Boichard, Gwendal Restoux   +2 more
wiley   +1 more source