Results 51 to 60 of about 12,794 (224)

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Scrapie-resistant sheep show certain coat colour characteristics

, 2009
Susceptibility to scrapie is known to be associated with polymorphisms at the prion protein (PrP) gene, and this association is the basis of current selective programmes implemented to control scrapie in many Countries.
White, I, Brotherstone, S., White, I., Sawalha, RM, Villanueva, B., Villanueva, B, Wilson, A. J., Brotherstone, S, Wilson, AJ, Bell, L., Bell, L, Sawalha, R. M.   +11 more
core   +1 more source

A Practice Framework for Genetic Testing in Asymptomatic Relatives of Patients With Creutzfeldt‐Jakob Disease: Experience and Insights From Israel

European Journal of Neurology, Volume 33, Issue 6, June 2026.
Presymptomatic genetic testing for genetic Creutzfeldt‐Jakob disease requires careful balancing of autonomy, psychological preparedness, and potential familial implications. Based on multidisciplinary experience in Israel, we propose a structured framework including pre‐test counseling, psychological appraisal, genetic testing, in‐person results ...
Dror Shir, Noa Bregman, Aya Bar David, Talya Nathan, Orly Goldstein, Tanya Gurevich, Avner Thaler, Anat Mirelman, Tamara Shiner, Mali Gana Weisz, Shiri Shkedi‐Rafid, Gael Ganz, Hagit Shani, Elon Pras, Odelia Chorin, Gia Sorkin, Keren Markus‐Bustani, Shlomzion Kahana Merhavi, Mor Shechory‐Stahl, Miri Yanoov Sharav, Michal Dicastro, Dorin Trigubov, Dalit Barel, Esther Kahana, Avi Fellner, Amos Korczyn, Hagit Baris Feldman, Lior Greenbaum, Nurit Omer   +28 more
wiley   +1 more source

Genetic Diversity in Dutch Sheep Breeds

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT The Netherlands has a rich variety of native sheep breeds, most of them at risk or endangered. We studied the distinctiveness of these breeds, their genetic diversity within and between breeds, and how this diversity is shaped by geography, purpose, history and genetic management practices.
J. Noëlle Hoorneman, Mira A. Schoon, Richard P. M. A. Crooijmans, Sipke Joost Hiemstra, Jack J. Windig   +4 more
wiley   +1 more source

Scrapie Resistance Gene Identification using Optimized Taqman Test qPCR Method in Sheep on the Territory of the Republic of Serbia

Acta Veterinaria, 2021
Scrapie is an infectious neurodegenerative disease affecting the central nervous system of sheep and goats that belongs to transmissible spongiform encephalopathies.
Nešić Slađan, Jelisić Stefan, Aleksić-Kovačević Sanja, Aničić Milan, Vučićević Ivana   +4 more
doaj   +1 more source

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, Volume 99, Issue 4, Page 897-911, April 2026.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie

, 2010
With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (
Bossers, A., A. Bossers, Y. Tang, Sauer, M., M. Sauer, L. J. M. van Keulen, J. P. M. Langeveld, J. G. Jacobs, Keulen, L.J.M., van, van Keulen, L.J.M., Tang, Y., Jacobs, J.G., Langeveld, J.P.M.   +12 more
core   +1 more source

Pruritus is a common feature in sheep infected with the BSE agent. [PDF]

, 2008
BACKGROUND: The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain ...
Vidal-Diez, Alberto, Chaplin, Melanie J., Simmons, MM, Marion M Simmons, Chaplin, Melani J., Dexter, Glenda, Vidal-Diez, A, Martin Jeffrey, Christine Berthelin-Baker, Bone Gemma, Melanie J Chaplin, Glenda Dexter, Konold Timm, Tortosa Méndez, Raül, Peter Hill, Simmons Marion M, Simmons, Marion M., Tortosa Raul, Chaplin Melanie J, Davis Andrew, Berthelin-Baker, C, Bellworthy, SJ, Dexter Glenda, Bellworthy Susan J, Chaplin, MJ, Susan J Bellworthy, Bellworthy, Susan J., Timm Konold, Hill, P, Berthelin-Baker Christine, Gemma Bone, Raul Tortosa, Tortosa, R, Vidal-Diez Alberto, Jeffrey Martin, Hill, Peter, Konold, T, Hill Peter, Tortosa, Raul, Berthelin-Baker, Christine, Dexter, G, Davis, Andrew, Bone, G, Davis, A, Vidal Díez, Alberto, Jeffrey, M, Bone, Gemma, Jeffrey, Martin, Konold, Timm, Andrew Davis, Alberto Vidal-Diez   +50 more
core   +1 more source

Incidence of infection in Prnp ARR/ARR sheep following experimental inoculation with or natural exposure to classical scrapie. [PDF]

PLoS ONE, 2014
The prion protein gene (Prnp) is highly influential in determining risk and susceptibility of sheep exposed to classical scrapie. Sheep homozygous for alanine at codon 136 and arginine at codons 154 and 171 (ARR/ARR) of the Prnp gene are historically ...
Martin Jeffrey, Stuart Martin, Francesca Chianini, Samantha Eaton, Mark P Dagleish, Lorenzo González   +5 more
doaj   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, Volume 39, Issue 3, Page 346-367, April 2026.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source