Results 31 to 40 of about 16,279 (223)

White-Tailed Deer Prion Protein Gene Variability Suggests Selection Against Chronic Wasting Disease in Canada’s Prairies

Viruses
Chronic wasting disease (CWD), a transmissible spongiform encephalopathy that targets cervids, has become a significant threat to both free-ranging and captive populations of Canadian white-tailed deer.
William Pilot, Maria I. Arifin, Antanas Staskevicius, Nicholas J. Haley, Gordon Mitchell, Jiewen Guan   +5 more
doaj   +1 more source

Clinical findings in two cases of atypical scrapie in sheep: a case report

BMC Veterinary Research, 2007
Background Atypical scrapie is a recently recognised form of transmissible spongiform encephalopathy of sheep that differs from classical scrapie in its neuropathological and biochemical features.
Chaplin Melanie, Everitt Sharon, Bracegirdle John, Bone Gemma, Davis Andrew, Konold Timm, Saunders Ginny C, Cawthraw Saira, Simmons Marion M   +8 more
doaj   +1 more source

Implications of conflicting associations of the prion protein (PrP) gene with scrapie susceptibility and fitness on the persistence of scrapie.

PLoS ONE, 2009
BackgroundExisting mathematical models for scrapie dynamics in sheep populations assume that the PrP gene is only associated with scrapie susceptibility and with no other fitness related traits.
Andrea Doeschl-Wilson, Rami Sawalha, Simon Gubbins, Beatriz Villanueva   +3 more
doaj   +1 more source

Transmission of scrapie prions to primate after an extended silent incubation period

Scientific Reports, 2015
Classical bovine spongiform encephalopathy (c-BSE) is the only animal prion disease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having guided protective measures for animal and human health against animal prion ...
E. Comoy, J. Mikol, S. Luccantoni-Freire, E. Correia, Nathalie Lescoutra-etchegaray, V. Durand, C. Dehen, O. Andréoletti, C. Casalone, J. Richt, J. Greenlee, T. Baron, S. Benestad, P. Brown, J. Deslys   +14 more
semanticscholar   +1 more source

Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance

BMC Veterinary Research, 2010
Background Susceptibility of sheep to scrapie infection is known to be modulated by the PrP genotype of the animal. In the Netherlands an ambitious scrapie control programme was started in 1998, based on genetic selection of animals for breeding.
Engel Bas, Davidse Aart, Bossers Alex, Melchior Marielle B, Hagenaars Thomas J, van Zijderveld Fred G   +5 more
doaj   +1 more source

Scrapie versus Chronic Wasting Disease in White-Tailed Deer

Emerging Infectious Diseases
White-tailed deer are susceptible to scrapie (WTD scrapie) after oronasal inoculation with the classical scrapie agent from sheep. Deer affected by WTD scrapie are difficult to differentiate from deer infected with chronic wasting disease (CWD).
Zoe J. Lambert, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, Justin J. Greenlee   +4 more
doaj   +1 more source

The placenta shed from goats with classical scrapie is infectious to goat kids and lambs

Journal of General Virology, 2015
The placenta of domestic sheep plays a key role in horizontal transmission of classical scrapie. Domestic goats are frequently raised with sheep and are susceptible to classical scrapie, yet potential routes of transmission from goats to sheep are not ...
D. Schneider, Sally A. Madsen-Bouterse, D. Zhuang, T. Truscott, R. Dassanayake, K. O'Rourke   +5 more
semanticscholar   +1 more source

Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype. [PDF]

PLoS ONE, 2009
Atypical scrapie or Nor98 has been identified as a transmissible spongiform encephalopathy (TSE) that is clearly distinguishable from classical scrapie and BSE, notably regarding the biochemical features of the protease-resistant prion protein PrP(res ...
Jean-Noël Arsac, Dominique Bétemps, Eric Morignat, Cécile Féraudet, Anna Bencsik, Denise Aubert, Jacques Grassi, Thierry Baron   +7 more
doaj   +1 more source

Modeling localized deer removal strategies for managing chronic wasting disease

The Journal of Wildlife Management, EarlyView.
We used an agent‐based model developed for chronic wasting disease (CWD) in Midwestern white‐tailed deer to assess localized deer removal strategies and how local conditions affect management outcomes. Parcel‐based and ring culling were most effective at reducing CWD prevalence and persistence, and transmission was always greater at greater deer ...
Noelle E. Thompson, Daniel J. O'Brien, Daniel P. Walsh, Chad M. Stewart, Earl G. Krom, Gary J. Roloff   +5 more
wiley   +1 more source

Histopathological studies of "CH1641-like" scrapie sources versus classical scrapie and BSE transmitted to ovine transgenic mice (TgOvPrP4).

PLoS ONE, 2011
The possibility of the agent causing bovine spongiform encephalopathy (BSE) infecting small ruminants is of serious concern for human health. Among scrapie cases, the CH1641 source in particular appears to have certain biochemical properties similar to ...
Anna Bencsik, Thierry Baron
doaj   +1 more source