Results 31 to 40 of about 8,594 (178)

Histopathological studies of "CH1641-like" scrapie sources versus classical scrapie and BSE transmitted to ovine transgenic mice (TgOvPrP4).

PLoS ONE, 2011
The possibility of the agent causing bovine spongiform encephalopathy (BSE) infecting small ruminants is of serious concern for human health. Among scrapie cases, the CH1641 source in particular appears to have certain biochemical properties similar to ...
Anna Bencsik, Thierry Baron
doaj   +1 more source

Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer.

PLoS Pathogens, 2023
Prion agents occur in strains that are encoded by the structure of the misfolded prion protein (PrPSc). Prion strains can influence disease phenotype and the potential for interspecies transmission.
Robyn D Kokemuller, S Jo Moore, Jifeng Bian, M Heather West Greenlee, Justin J Greenlee   +4 more
doaj   +1 more source

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source

Evidence of scrapie transmission via milk

BMC Veterinary Research, 2008
Background The risk of scrapie infection increases with increased duration and proximity of contact between sheep at lambing. Scrapie infectivity has not been detected in milk but cellular prion protein, the precursor of disease-associated prion protein ...
Moore S Jo, Konold Timm, Bellworthy Susan J, Simmons Hugh A   +3 more
doaj   +1 more source

Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie

Scientific Reports, 2021
Pigs are susceptible to infection with the classical bovine spongiform encephalopathy (C-BSE) agent following experimental inoculation, and PrPSc accumulation was detected in porcine tissues after the inoculation of certain scrapie and chronic wasting ...
Belén Marín, Alicia Otero, Séverine Lugan, Juan Carlos Espinosa, Alba Marín-Moreno, Enric Vidal, Carlos Hedman, Antonio Romero, Martí Pumarola, Juan J. Badiola, Juan María Torres, Olivier Andréoletti, Rosa Bolea   +12 more
doaj   +1 more source

Space and resource use by American crow Corvus brachyrhynchos in an area endemic for chronic wasting disease

Wildlife Biology, EarlyView.
American crow Corvus brachyrhynchos is a common species throughout North America. Crows play a role in the ecology of multiple diseases and a single laboratory experiment has shown the potential for crows to pass infectious prions, such as those associated with chronic wasting disease (CWD), in their feces after being force‐fed with infected material ...
Tyler S. Walters, Kurt C. VerCauteren, W. David Walter   +2 more
wiley   +1 more source

Genotyping and surveillance for scrapie in Finnish sheep

BMC Veterinary Research, 2012
Background The progression of scrapie is known to be influenced by the amino acid polymorphisms of the host prion protein (PrP) gene. There is no breeding programme for TSE resistance in sheep in Finland, but a scrapie control programme has been in place
Hautaniemi Maria, Tapiovaara Hannele, Korpenfelt Sirkka-Liisa, Sihvonen Liisa   +3 more
doaj   +1 more source

The limits of test-based scrapie eradication programs in goats. [PDF]

PLoS ONE, 2013
Small ruminant post-mortem testing programs were initially designed for monitoring the prevalence of prion disease. They are now considered as a potential alternative to genetic selection for eradicating/controlling classical scrapie at population level.
Fabien Corbière, Cécile Chauvineau-Perrin, Caroline Lacroux, Séverine Lugan, Pierrette Costes, Myriam Thomas, Isabelle Brémaud, Christophe Chartier, Francis Barillet, François Schelcher, Olivier Andréoletti   +10 more
doaj   +1 more source

The Exceptions to the Central Dogma of Biology—Bending the Rules and Extending the Scope

Natural Sciences, Volume 6, Issue 4, October 2026.
ABSTRACT The central dogma is an organizing framework for how information flows in biological systems. First presented in 1957 by Francis Crick in his talk “On Protein Synthesis” as a fundamental hypothesis of how information is transferred from DNA to proteins but not out of proteins, it is now introduced in cell biology textbooks as three sequential ...
Anat Ben‐Zvi
wiley   +1 more source

Modeling localized deer removal strategies for managing chronic wasting disease

The Journal of Wildlife Management, Volume 90, Issue 7, September 2026.
We used an agent‐based model developed for chronic wasting disease (CWD) in Midwestern white‐tailed deer to assess localized deer removal strategies and how local conditions affect management outcomes. Parcel‐based and ring culling were most effective at reducing CWD prevalence and persistence, and transmission was always greater at greater deer ...
Noelle E. Thompson, Daniel J. O'Brien, Daniel P. Walsh, Chad M. Stewart, Earl G. Krom, Gary J. Roloff   +5 more
wiley   +1 more source