Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection. [PDF]
PLoS ONE, 2011 Prions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which has been exploited successfully ...
Sandra Pritzkow +7 more
doaj +1 more source
A quantitative assessment of the prion risk associated with wastewater from carcase-handling facilities [PDF]
, 2013 Wastewater from facilities processing livestock that may harbor transmissible spongiform encephalopathies (TSEs) infectivity is permitted under license for application to land where susceptible livestock may have access. Several previous risk assessments
Adkin +24 more
core +1 more source
Atypical scrapie in sheep from a UK research flock which is free from classical scrapie
BMC Veterinary Research, 2009 Background In the wake of the epidemic of bovine spongiform encephalopathy the British government established a flock of sheep from which scrapie-free animals are supplied to laboratories for research.
Ortiz-Pelaez Angel +9 more
doaj +1 more source
Atypical scrapie isolates involve a uniform prion species with a complex molecular signature. [PDF]
PLoS ONE, 2011 The pathobiology of atypical scrapie, a prion disease affecting sheep and goats, is still poorly understood. In a previous study, we demonstrated that atypical scrapie affecting small ruminants in Switzerland differs in the neuroanatomical distribution ...
Dorothea R Götte +5 more
doaj +1 more source
A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrPres [PDF]
, 2006 Prion diseases are associated with the conversion of the normal cellular prion protein, PrPc, to the abnormal, disease-associated form, PrPSc. This conversion can be mimicked in vitro by using a cell-free conversion assay. It has recently been shown that
Gill, Andrew C. +4 more
core +1 more source
Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission
Frontiers in Veterinary Science, 2015 Classical scrapie is an environmentally transmissible prion disease of sheep and goats. Prions can persist and remain potentially infectious in the environment for many years and thus pose a risk of infecting animals after re-stocking.
Timm eKonold +6 more
doaj +1 more source
Low-volume goat milk transmission of classical scrapie to lambs and goat kids. [PDF]
PLoS ONE, 2018 The risk of classical scrapie transmission in small ruminants is highest during the neonatal period with the placenta recognized as a significant source of infection.
Sally A Madsen-Bouterse +4 more
doaj +1 more source
Rapid testing leads to the underestimation of the scrapie prevalence in an affected sheep and goat flock [PDF]
, 2007 To obtain a more detailed understanding of the prevalence of classical scrapie infections in a heavily affected German sheep flock (composed of 603 sheep and 6 goats), we analysed 169 sheep and 6 goats that carried the genotypes susceptible to the ...
Bellmann, Steffi +10 more
core +2 more sources
Clinical findings in two cases of atypical scrapie in sheep: a case report
BMC Veterinary Research, 2007 Background Atypical scrapie is a recently recognised form of transmissible spongiform encephalopathy of sheep that differs from classical scrapie in its neuropathological and biochemical features.
Chaplin Melanie +8 more
doaj +1 more source
VirusesChronic wasting disease (CWD), a transmissible spongiform encephalopathy that targets cervids, has become a significant threat to both free-ranging and captive populations of Canadian white-tailed deer.
William Pilot +5 more
doaj +1 more source