Results 11 to 20 of about 12,794 (224)

Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance [PDF]

BMC Veterinary Research, 2010
Background Susceptibility of sheep to scrapie infection is known to be modulated by the PrP genotype of the animal. In the Netherlands an ambitious scrapie control programme was started in 1998, based on genetic selection of animals for breeding.
Engel Bas, Davidse Aart, Bossers Alex, Melchior Marielle B, Hagenaars Thomas J, van Zijderveld Fred G   +5 more
doaj   +2 more sources

Diversity in neuroanatomical distribution of abnormal prion protein in atypical scrapie. [PDF]

PLoS Pathogens, 2007
Scrapie is a transmissible spongiform encephalopathy (TSE) in sheep and goats. In recent years, atypical scrapie cases were identified that differed from classical scrapie in the molecular characteristics of the disease-associated pathological prion ...
Alice Nentwig, Anna Oevermann, Dagmar Heim, Catherine Botteron, Karola Zellweger, Cord Drögemüller, Andreas Zurbriggen, Torsten Seuberlich   +7 more
doaj   +2 more sources

Prnp Deletion Mitigates Muscle Fiber Type-Specific Sarcopenia Induced by Prion Infection in Mice. [PDF]

Immun Inflamm Dis
ABSTRACT Recent studies have shown that significant expression of PrPC protein is also present in skeletal muscle, and it plays a significant role in maintaining skeletal muscle homeostasis. Although the expression of PrPC in skeletal muscle has been clarified, the effects of PrPSc‐mediated prion protein infection on sarcopenia in mice and its ...
Liu W, Kim YC, Won SY, Kieu TTT, Kook SH, Jeong BH, Kim SH.   +6 more
europepmc   +2 more sources

The European Union summary report on surveillance for the presence of transmissible spongiform encephalopathies (TSE) in 2024. [PDF]

EFSA J
ABSTRACT This report presents results of surveillance on transmissible spongiform encephalopathies in bovines, sheep, goats, cervids and other species, and genotyping in sheep and goats, carried out in 2024 by 27 EU Member States (EU27, MS), the UK (in respect of Northern Ireland, (XI)) and 8 non‐EU reporting countries: Bosnia and Herzegovina, Iceland,
European Food Safety Authority (EFSA), Nonno R, Ru G, Aminalragia-Giamini R, Iancu C, Ortiz-Pelaez A, Kryemadhi K, Baldinelli F.   +7 more
europepmc   +2 more sources

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains. [PDF]

Brain Pathol
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Eraña H, Vidal E, Fernández-Borges N, Charco JM, Díaz-Domínguez CM, Sampedro-Torres-Quevedo C, Galarza-Ahumada J, Fernández-Muñoz E, San-Juan-Ansoleaga M, Pérez-Castro MÁ, Gonçalves-Anjo N, Piñeiro P, Giler S, González-Martín N, Lorenzo NL, Manero-Azua A, Perez de Nanclares G, Geijo M, Sánchez-Martín MA, Requena JR, Castilla J.   +20 more
europepmc   +2 more sources

Demographic risk factors for classical and atypical scrapie in Great Britain [PDF]

, 2007
Following the bovine spongiform encephalopathy (BSE) crisis, the European Union has introduced policies for eradicating transmissible spongiform encephalopathies (TSEs), including scrapie, from large ruminants. However, recent European Union surveillance
Noel D McCarthy (16058201), Green, Darren, McCarthy, N.D., Kao, Rowland R, Kao, RR, del Rio Vilas, V.J., Kiss, I.Z., del Rio Vilas, Victor J, Kiss, IZ, del Rio Vilas, VJ, McCarthy, Noel D, Colin P D Birch (16058198), Darren M Green (16058192), Jethro Johnson (12099290), Kao, R.R., Victor J del Rio Vilas (16058195), Green, D.M., Johnson, J., McCarthy, ND, Istvan Kiss (4462126), Kiss, Istvan Z, Johnson, Jethro, Birch, CPD, Green, DM, Johnson, J, Birch, CP, Rowland R Kao (16058204), Birch, C.P.D., Birch, Colin P D   +28 more
core   +1 more source

Proteinase K-Resistant Material in ARR/VRQ Sheep Brain Affected with Classical Scrapie Is Composed Mainly of VRQ Prion Protein [PDF]

, 2011
Classical scrapie is a prion disease in sheep and goats. In sheep, susceptibility to disease is genetically influenced by single amino acid substitutions.
Bossers, A., A. Bossers, T. Sklaviadis, I. Lantier, F. Lantier, L. J. M. van Keulen, Van Keulen, L., S. McCutcheon, Berthon, P., Lantier, Isabelle, van Keulen, L.J.M., van Zijderveld, F.G., P. Berthon, Lantier, Frédéric, F., Zijderveld, F.G., van, Jacobs, J.G., Keulen, L., Van, Langeveld, J.P.M., Lantier, I., H. Rezaei, J. P. M. Langeveld, Rezaei, Human, Sklaviadis, T., Berthon, Patricia, J. G. Jacobs, F. G. van Zijderveld, Lantier, F., McCutcheon, S., Rezaei, H.   +28 more
core   +1 more source

Advanced survival models for risk-factor analysis in scrapie [PDF]

, 2007
Because of the confounding effects of long incubation duration and flock management, accurate epidemiological studies of scrapie outbreaks are difficult to carry out.
Joly, Pierre, Fidelle, Francis, Schelcher, François, Barillet, Francis, Andréoletti, Olivier, Corbière, Fabien, Laphitz-Bordet, Nathalie   +6 more
core   +1 more source

An economic evaluation of preclinical testing strategies compared to the compulsory scrapie flock scheme in the control of classical scrapie [PDF]

, 2012
Cost-benefit is rarely combined with nonlinear dynamic models when evaluating control options for infectious diseases. The current strategy for scrapie in Great Britain requires that all genetically susceptible livestock in affected flocks be culled ...
Fiona Houston, Kao, R., Boden, L., Kao, Rowland, Fryer Helen, Hawkins, Neil, Helen Fryer, Handel, I., Boden Lisa, Hawkins, N., Handel Ian, Ian Handel, Fryer, Helen, Houston Fiona, Kao Rowland, Handel, Ian, Hawkins Neil, Rowland Kao, Fryer, H., Boden, Lisa, Houston, Fiona, Lisa Boden, Houston, F., Neil Hawkins   +23 more
core   +1 more source

Monitoring of clinical signs in goats with transmissible spongiform encephalopathies

BMC Veterinary Research, 2010
Background As there is limited information about the clinical signs of BSE and scrapie in goats, studies were conducted to describe the clinical progression of scrapie and BSE in goats and to evaluate a short clinical protocol for its use in detecting ...
Goldmann Wilfred, Sisó Sílvia, González Lorenzo, Simmons Marion M, Phelan Laura J, Bone Gemma E, Konold Timm, Cawthraw Saira, Hawkins Steve AC   +8 more
doaj   +1 more source