Results 11 to 20 of about 16,279 (223)
Prnp Deletion Mitigates Muscle Fiber Type-Specific Sarcopenia Induced by Prion Infection in Mice. [PDF]
Immun Inflamm DisABSTRACT Recent studies have shown that significant expression of PrPC protein is also present in skeletal muscle, and it plays a significant role in maintaining skeletal muscle homeostasis. Although the expression of PrPC in skeletal muscle has been clarified, the effects of PrPSc‐mediated prion protein infection on sarcopenia in mice and its ...
Liu W +6 more
europepmc +2 more sources
The European Union summary report on surveillance for the presence of transmissible spongiform encephalopathies (TSE) in 2024. [PDF]
EFSA JABSTRACT This report presents results of surveillance on transmissible spongiform encephalopathies in bovines, sheep, goats, cervids and other species, and genotyping in sheep and goats, carried out in 2024 by 27 EU Member States (EU27, MS), the UK (in respect of Northern Ireland, (XI)) and 8 non‐EU reporting countries: Bosnia and Herzegovina, Iceland,
European Food Safety Authority (EFSA) +7 more
europepmc +2 more sources
The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains. [PDF]
Brain PatholA single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Eraña H +20 more
europepmc +2 more sources
Iron and iron/manganese ratio in forage from Icelandic sheep farms: relation to scrapie
Acta Veterinaria Scandinavica, 2006 This study was undertaken in order to examine whether any connection existed between the amounts of iron in forage and the sporadic occurrence of scrapie observed in certain parts of Iceland.
Jóhannesson T +4 more
doaj +1 more source
PLoS ONE, 2022 Nor98-like atypical scrapie is a sporadic disease that affects the central nervous system of sheep and goats that, in contrast to classical scrapie, is not generally regarded as naturally transmissible.
Robert B Piel +7 more
doaj +2 more sources
BMC Veterinary Research, 2008 Background The development of active surveillance programmes for transmissible spongiform encephalopathies of small ruminants across Europe has led to the recent identification of a previously undetected form of ovine prion disease, 'atypical' scrapie ...
Calavas Didier +5 more
doaj +1 more source
Classical scrapie in small ruminants is caused by at least four different prion strains
Veterinary Research, 2021 The diversity of goat scrapie strains in Europe has recently been studied using bioassays in a wide collection of rodent models, resulting in the classification of classical scrapie into four different categories.
Alba Marín-Moreno +10 more
doaj +1 more source
Acta Veterinaria Scandinavica, 2008 Background Preliminary studies indicated decreased glutathione peroxidase (GPX) activity in blood of ewes on scrapie-afflicted farms. Other studies have shown decreased GPX activity in brain of prion-infected mice and in prion-infected cells in vitro ...
Eiríksson Tryggvi +4 more
doaj +1 more source
BMC Veterinary Research, 2010 Background During the last decade, active surveillance for transmissible spongiform encephalopathies in small ruminants has been intensive in Europe. In many countries this has led to the detection of cases of atypical scrapie which, unlike classical ...
Liam Barry +11 more
doaj +1 more source
Monitoring of clinical signs in goats with transmissible spongiform encephalopathies
BMC Veterinary Research, 2010 Background As there is limited information about the clinical signs of BSE and scrapie in goats, studies were conducted to describe the clinical progression of scrapie and BSE in goats and to evaluate a short clinical protocol for its use in detecting ...
Goldmann Wilfred +8 more
doaj +1 more source