Results 11 to 20 of about 29,784 (268)

Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

Animal, 2016
Scrapie is a naturally occurring transmissible spongiform encephalopathy in sheep and goat. It has been known for ~250 years and is characterised by the accumulation of an abnormal isoform of a host-encoded prion protein that leads to progressive ...
L. Curcio, C. Sebastiani, P. Di Lorenzo, E. Lasagna, M. Biagetti   +4 more
doaj   +2 more sources

Evidence in sheep for pre-natal transmission of scrapie to lambs from infected mothers.

PLoS ONE, 2013
Natural scrapie transmission from infected ewes to their lambs is thought to occur by the oral route around the time of birth. However the hypothesis that scrapie transmission can also occur before birth (in utero) is not currently favoured by most ...
James D Foster, Wilfred Goldmann, Nora Hunter   +2 more
doaj   +2 more sources

Prnp Deletion Mitigates Muscle Fiber Type-Specific Sarcopenia Induced by Prion Infection in Mice. [PDF]

Immun Inflamm Dis
ABSTRACT Recent studies have shown that significant expression of PrPC protein is also present in skeletal muscle, and it plays a significant role in maintaining skeletal muscle homeostasis. Although the expression of PrPC in skeletal muscle has been clarified, the effects of PrPSc‐mediated prion protein infection on sarcopenia in mice and its ...
Liu W, Kim YC, Won SY, Kieu TTT, Kook SH, Jeong BH, Kim SH.   +6 more
europepmc   +2 more sources

The European Union summary report on surveillance for the presence of transmissible spongiform encephalopathies (TSE) in 2024. [PDF]

EFSA J
ABSTRACT This report presents results of surveillance on transmissible spongiform encephalopathies in bovines, sheep, goats, cervids and other species, and genotyping in sheep and goats, carried out in 2024 by 27 EU Member States (EU27, MS), the UK (in respect of Northern Ireland, (XI)) and 8 non‐EU reporting countries: Bosnia and Herzegovina, Iceland,
European Food Safety Authority (EFSA), Nonno R, Ru G, Aminalragia-Giamini R, Iancu C, Ortiz-Pelaez A, Kryemadhi K, Baldinelli F.   +7 more
europepmc   +2 more sources

Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene

Veterinary Research, 2012
Susceptibility of sheep to scrapie, a transmissible spongiform encephalopathy of small ruminants, is strongly influenced by polymorphisms of the prion protein gene (PRNP).
Acutis Pier Luigi, Martucci Francesca, D'Angelo Antonio, Peletto Simone, Colussi Silvia, Maurella Cristiana, Porcario Chiara, Iulini Barbara, Mazza Maria, Dell'Atti Luana, Zuccon Fabio, Corona Cristiano, Martinelli Nicola, Casalone Cristina, Caramelli Maria, Lombardi Guerino   +15 more
doaj   +2 more sources

Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases

Animals, 2021
Simple Summary Classical scrapie is a prionic, neurological, consumptive, and chronic disease that affects naturally domestic small ruminants. It was initially described in the UK, and since then it has spread throughout the world.
C. Acín, R. Bolea, M. Monzón, E. Monleón, B. Moreno, Hicham Filali, B. Marín, D. Sola, M. Betancor, Isabel M Guijarro, M. García, A. Vargas, J. Badiola   +12 more
semanticscholar   +1 more source

Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep [PDF]

, 2006
The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms
Andréoletti, Banks, Baron, Baylis, Bieschke, Brown, Buschmann, Catherine Viguié, Chantal Imbs, Ecroyd, Elsen, Green, Hunter, Le Dur, Mohammed Moudjou, Morel, Moudjou, Nicole Picard-Hagen, Pierre-Louis Toutain, Rezaei, Safar, Toutain, Véronique Gayrard, Weller, Wong   +24 more
core   +3 more sources

Classical scrapie in small ruminants is caused by at least four different prion strains

Veterinary Research, 2021
The diversity of goat scrapie strains in Europe has recently been studied using bioassays in a wide collection of rodent models, resulting in the classification of classical scrapie into four different categories.
Alba Marín-Moreno, Patricia Aguilar-Calvo, Juan Carlos Espinosa, María Zamora-Ceballos, José Luis Pitarch, Lorenzo González, Natalia Fernández-Borges, Leonor Orge, Olivier Andréoletti, Romolo Nonno, Juan María Torres   +10 more
doaj   +1 more source

Prion diseases are efficiently transmitted by blood transfusion in sheep [PDF]

, 2008
The emergence of variant Creutzfeld-Jakob disease, following on from the bovine spongiform encephalopathy (BSE) epidemic, led to concerns about the potential risk of iatrogenic transmission of disease by blood transfusion and the introduction of costly ...
Andréoletti, Angela Chong, Bishop, Brown, Castilla, Clarke, Fiona Houston, Goldmann, Goldmann, Goldmann, González, González, Gregori, Gregori, Hadlow, Hewitt, Hill, Hilton, Houston, Houston, Hunter, Ironside, James Foster, Jeffrey, Jeffrey, Jeffrey, Kirby, Llewelyn, Lorenzo González, Martin Jeffrey, Mead, Nora Hunter, O'Rourke, Peden, Sandra McCutcheon, Saá, Schreuder, Silvia Sisó, Sisó, Valleron, van Keulen, Wilfred Goldmann, Will, Wroe   +43 more
core   +1 more source

Glutathione peroxidase (GPX) activity in blood of ewes on farms in different scrapie categories in Iceland

Acta Veterinaria Scandinavica, 2008
Background Preliminary studies indicated decreased glutathione peroxidase (GPX) activity in blood of ewes on scrapie-afflicted farms. Other studies have shown decreased GPX activity in brain of prion-infected mice and in prion-infected cells in vitro ...
Eiríksson Tryggvi, Sigurdarson Sigurdur, Kristinsson Jakob, Gudmundsdóttir Kristín B, Jóhannesson Torkell   +4 more
doaj   +1 more source