Results 11 to 20 of about 8,594 (178)

Prnp Deletion Mitigates Muscle Fiber Type‐Specific Sarcopenia Induced by Prion Infection in Mice [PDF]

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Recent studies have shown that significant expression of PrPC protein is also present in skeletal muscle, and it plays a significant role in maintaining skeletal muscle homeostasis. Although the expression of PrPC in skeletal muscle has been clarified, the effects of PrPSc‐mediated prion protein infection on sarcopenia in mice and its ...
Wenduo Liu, Yong‐Chan Kim, Sae‐Young Won, Thi Thu Trang Kieu, Sung Ho Kook, Byung‐Hoon Jeong, Sang Hyun Kim   +6 more
wiley   +2 more sources

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains [PDF]

Brain Pathology, Volume 36, Issue 4, July 2026.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +2 more sources

The prevalence of atypical scrapie in sheep from positive flocks is not higher than in the general sheep population in 11 European countries

BMC Veterinary Research, 2010
Background During the last decade, active surveillance for transmissible spongiform encephalopathies in small ruminants has been intensive in Europe. In many countries this has led to the detection of cases of atypical scrapie which, unlike classical ...
Liam Barry, Hautaniemi Maria, Poizat Renaud, Orge Leonor, Thorgeirsdottir Stefania, Ingravalle Francesco, Nöremark Maria, Maurella Cristiana, Fediaevsky Alexandre, Calavas Didier, Ru Giuseppe, Hopp Petter   +11 more
doaj   +1 more source

Monitoring of clinical signs in goats with transmissible spongiform encephalopathies

BMC Veterinary Research, 2010
Background As there is limited information about the clinical signs of BSE and scrapie in goats, studies were conducted to describe the clinical progression of scrapie and BSE in goats and to evaluate a short clinical protocol for its use in detecting ...
Goldmann Wilfred, Sisó Sílvia, González Lorenzo, Simmons Marion M, Phelan Laura J, Bone Gemma E, Konold Timm, Cawthraw Saira, Hawkins Steve AC   +8 more
doaj   +1 more source

Norwegian farmers' vigilance in reporting sheep showing scrapie-associated signs

BMC Veterinary Research, 2007
Background Scrapie is a chronic neurodegenerative disease affecting small ruminants and belongs to the transmissible spongiform encephalopathies. Scrapie is considered a serious animal disease and it has been notifiable in Norway since 1965. The clinical
Jarp Jorun, Vatn Synnøve, Hopp Petter
doaj   +1 more source

Evaluation of Antemortem Diagnostic Techniques in Goats Naturally Infected With Scrapie

Frontiers in Veterinary Science, 2020
Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) that affects sheep and goats. Sheep and goats can be infected with scrapie as lambs or kids via contact with the placenta or placental fluids, or from ingestion of prions shed
Najiba Mammadova, M. Heather West Greenlee, S. Jo Moore, Soyoun Hwang, Aaron D. Lehmkuhl, Eric M. Nicholson, Justin J. Greenlee   +6 more
doaj   +1 more source

Transmission of the atypical/Nor98 scrapie agent to Suffolk sheep with VRQ/ARQ, ARQ/ARQ, and ARQ/ARR genotypes.

PLoS ONE, 2021
Scrapie is a transmissible spongiform encephalopathy that occurs in sheep. Atypical/Nor98 scrapie occurs in sheep that tend to be resistant to classical scrapie and it is thought to occur spontaneously.
Eric D Cassmann, Najiba Mammadova, S Jo Moore, Sylvie Benestad, Justin J Greenlee   +4 more
doaj   +1 more source

Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection. [PDF]

PLoS ONE, 2011
Prions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which has been exploited successfully ...
Sandra Pritzkow, Katja Wagenführ, Martin L Daus, Susann Boerner, Karin Lemmer, Achim Thomzig, Martin Mielke, Michael Beekes   +7 more
doaj   +1 more source

Atypical scrapie isolates involve a uniform prion species with a complex molecular signature. [PDF]

PLoS ONE, 2011
The pathobiology of atypical scrapie, a prion disease affecting sheep and goats, is still poorly understood. In a previous study, we demonstrated that atypical scrapie affecting small ruminants in Switzerland differs in the neuroanatomical distribution ...
Dorothea R Götte, Sylvie L Benestad, Hubert Laude, Andreas Zurbriggen, Anna Oevermann, Torsten Seuberlich   +5 more
doaj   +1 more source

Atypical scrapie in sheep from a UK research flock which is free from classical scrapie

BMC Veterinary Research, 2009
Background In the wake of the epidemic of bovine spongiform encephalopathy the British government established a flock of sheep from which scrapie-free animals are supplied to laboratories for research.
Ortiz-Pelaez Angel, Davis Andrew, Povey Gill, Chaplin Melanie J, Spencer Yvonne I, Simmons Marion M, Simmons Hugh A, Hunter Nora, Matthews Danny, Wrathall Anthony E   +9 more
doaj   +1 more source