Scientific Reports, 2019 Small ruminants, including sheep and goats are natural hosts of scrapie, and the progression of scrapie pathogenesis is strongly influenced by polymorphisms in the prion protein gene (PRNP).
Seonkwan Kim +3 more
semanticscholar +1 more source
Norwegian farmers' vigilance in reporting sheep showing scrapie-associated signs
BMC Veterinary Research, 2007 Background Scrapie is a chronic neurodegenerative disease affecting small ruminants and belongs to the transmissible spongiform encephalopathies. Scrapie is considered a serious animal disease and it has been notifiable in Norway since 1965. The clinical
Jarp Jorun, Vatn Synnøve, Hopp Petter
doaj +1 more source
Evaluation of Antemortem Diagnostic Techniques in Goats Naturally Infected With Scrapie
Frontiers in Veterinary Science, 2020 Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) that affects sheep and goats. Sheep and goats can be infected with scrapie as lambs or kids via contact with the placenta or placental fluids, or from ingestion of prions shed
Najiba Mammadova +6 more
doaj +1 more source
PLoS ONE, 2021 Scrapie is a transmissible spongiform encephalopathy that occurs in sheep. Atypical/Nor98 scrapie occurs in sheep that tend to be resistant to classical scrapie and it is thought to occur spontaneously.
Eric D Cassmann +4 more
doaj +1 more source
Review: Update on Classical and Atypical Scrapie in Sheep and Goats
Veterinary Pathology-Supplement, 2018 Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion protein (PrPC) misfolds into a pathogenic form (PrPSc) that is highly ...
J. Greenlee
semanticscholar +1 more source
Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection. [PDF]
PLoS ONE, 2011 Prions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which has been exploited successfully ...
Sandra Pritzkow +7 more
doaj +1 more source
Atypical scrapie in sheep from a UK research flock which is free from classical scrapie
BMC Veterinary Research, 2009 Background In the wake of the epidemic of bovine spongiform encephalopathy the British government established a flock of sheep from which scrapie-free animals are supplied to laboratories for research.
Ortiz-Pelaez Angel +9 more
doaj +1 more source
Low-volume goat milk transmission of classical scrapie to lambs and goat kids. [PDF]
PLoS ONE, 2018 The risk of classical scrapie transmission in small ruminants is highest during the neonatal period with the placenta recognized as a significant source of infection.
Sally A Madsen-Bouterse +4 more
doaj +1 more source
Atypical scrapie isolates involve a uniform prion species with a complex molecular signature. [PDF]
PLoS ONE, 2011 The pathobiology of atypical scrapie, a prion disease affecting sheep and goats, is still poorly understood. In a previous study, we demonstrated that atypical scrapie affecting small ruminants in Switzerland differs in the neuroanatomical distribution ...
Dorothea R Götte +5 more
doaj +1 more source
Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission
Frontiers in Veterinary Science, 2015 Classical scrapie is an environmentally transmissible prion disease of sheep and goats. Prions can persist and remain potentially infectious in the environment for many years and thus pose a risk of infecting animals after re-stocking.
Timm eKonold +6 more
doaj +1 more source