Norwegian farmers' vigilance in reporting sheep showing scrapie-associated signs
BMC Veterinary Research, 2007 Background Scrapie is a chronic neurodegenerative disease affecting small ruminants and belongs to the transmissible spongiform encephalopathies. Scrapie is considered a serious animal disease and it has been notifiable in Norway since 1965. The clinical
Jarp Jorun, Vatn Synnøve, Hopp Petter
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PLoS ONE, 2021 Scrapie is a transmissible spongiform encephalopathy that occurs in sheep. Atypical/Nor98 scrapie occurs in sheep that tend to be resistant to classical scrapie and it is thought to occur spontaneously.
Eric D Cassmann +4 more
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Gene expression profiling en association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals. [PDF]
, 2011 The pathogenesis of natural scrapie and other prion diseases remains unclear. Examining transcriptome variations in infected versus control animals may highlight new genes potentially involved in some of the molecular mechanisms of prion-induced ...
Bossers, A. +34 more
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Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection. [PDF]
PLoS ONE, 2011 Prions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which has been exploited successfully ...
Sandra Pritzkow +7 more
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Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep [PDF]
, 2006 The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms
Vé Ronique Gayrard +13 more
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Evaluation of Antemortem Diagnostic Techniques in Goats Naturally Infected With Scrapie
Frontiers in Veterinary Science, 2020 Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) that affects sheep and goats. Sheep and goats can be infected with scrapie as lambs or kids via contact with the placenta or placental fluids, or from ingestion of prions shed
Najiba Mammadova +6 more
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Atypical scrapie isolates involve a uniform prion species with a complex molecular signature. [PDF]
PLoS ONE, 2011 The pathobiology of atypical scrapie, a prion disease affecting sheep and goats, is still poorly understood. In a previous study, we demonstrated that atypical scrapie affecting small ruminants in Switzerland differs in the neuroanatomical distribution ...
Dorothea R Götte +5 more
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Atypical scrapie in sheep from a UK research flock which is free from classical scrapie
BMC Veterinary Research, 2009 Background In the wake of the epidemic of bovine spongiform encephalopathy the British government established a flock of sheep from which scrapie-free animals are supplied to laboratories for research.
Ortiz-Pelaez Angel +9 more
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Prions in Milk from Ewes Incubating Natural Scrapie [PDF]
, 2008 Since prion infectivity had never been reported in milk, dairy products originating from transmissible spongiform encephalopathy (TSE)-affected ruminant flocks currently enter unrestricted into the animal and human food chain.
Bergonier Dominique +68 more
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Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission
Frontiers in Veterinary Science, 2015 Classical scrapie is an environmentally transmissible prion disease of sheep and goats. Prions can persist and remain potentially infectious in the environment for many years and thus pose a risk of infecting animals after re-stocking.
Timm eKonold +6 more
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