Results 21 to 30 of about 8,594 (178)

Implications of conflicting associations of the prion protein (PrP) gene with scrapie susceptibility and fitness on the persistence of scrapie.

PLoS ONE, 2009
BackgroundExisting mathematical models for scrapie dynamics in sheep populations assume that the PrP gene is only associated with scrapie susceptibility and with no other fitness related traits.
Andrea Doeschl-Wilson, Rami Sawalha, Simon Gubbins, Beatriz Villanueva   +3 more
doaj   +1 more source

Low-volume goat milk transmission of classical scrapie to lambs and goat kids. [PDF]

PLoS ONE, 2018
The risk of classical scrapie transmission in small ruminants is highest during the neonatal period with the placenta recognized as a significant source of infection.
Sally A Madsen-Bouterse, Margaret A Highland, Rohana P Dassanayake, Dongyue Zhuang, David A Schneider   +4 more
doaj   +1 more source

White-Tailed Deer Prion Protein Gene Variability Suggests Selection Against Chronic Wasting Disease in Canada’s Prairies

Viruses
Chronic wasting disease (CWD), a transmissible spongiform encephalopathy that targets cervids, has become a significant threat to both free-ranging and captive populations of Canadian white-tailed deer.
William Pilot, Maria I. Arifin, Antanas Staskevicius, Nicholas J. Haley, Gordon Mitchell, Jiewen Guan   +5 more
doaj   +1 more source

Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission

Frontiers in Veterinary Science, 2015
Classical scrapie is an environmentally transmissible prion disease of sheep and goats. Prions can persist and remain potentially infectious in the environment for many years and thus pose a risk of infecting animals after re-stocking.
Timm eKonold, Stephen Anthony Charles Hawkins, Lisa Claire Thurston, Benjamin Charles Maddison, Kevin Christopher Gough, Anthony eDuarte, Hugh Andrew Simmons   +6 more
doaj   +1 more source

Clinical findings in two cases of atypical scrapie in sheep: a case report

BMC Veterinary Research, 2007
Background Atypical scrapie is a recently recognised form of transmissible spongiform encephalopathy of sheep that differs from classical scrapie in its neuropathological and biochemical features.
Chaplin Melanie, Everitt Sharon, Bracegirdle John, Bone Gemma, Davis Andrew, Konold Timm, Saunders Ginny C, Cawthraw Saira, Simmons Marion M   +8 more
doaj   +1 more source

Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance

BMC Veterinary Research, 2010
Background Susceptibility of sheep to scrapie infection is known to be modulated by the PrP genotype of the animal. In the Netherlands an ambitious scrapie control programme was started in 1998, based on genetic selection of animals for breeding.
Engel Bas, Davidse Aart, Bossers Alex, Melchior Marielle B, Hagenaars Thomas J, van Zijderveld Fred G   +5 more
doaj   +1 more source

Evidence in sheep for pre-natal transmission of scrapie to lambs from infected mothers.

PLoS ONE, 2013
Natural scrapie transmission from infected ewes to their lambs is thought to occur by the oral route around the time of birth. However the hypothesis that scrapie transmission can also occur before birth (in utero) is not currently favoured by most ...
James D Foster, Wilfred Goldmann, Nora Hunter   +2 more
doaj   +1 more source

Scrapie versus Chronic Wasting Disease in White-Tailed Deer

Emerging Infectious Diseases
White-tailed deer are susceptible to scrapie (WTD scrapie) after oronasal inoculation with the classical scrapie agent from sheep. Deer affected by WTD scrapie are difficult to differentiate from deer infected with chronic wasting disease (CWD).
Zoe J. Lambert, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, Justin J. Greenlee   +4 more
doaj   +1 more source

Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype. [PDF]

PLoS ONE, 2009
Atypical scrapie or Nor98 has been identified as a transmissible spongiform encephalopathy (TSE) that is clearly distinguishable from classical scrapie and BSE, notably regarding the biochemical features of the protease-resistant prion protein PrP(res ...
Jean-Noël Arsac, Dominique Bétemps, Eric Morignat, Cécile Féraudet, Anna Bencsik, Denise Aubert, Jacques Grassi, Thierry Baron   +7 more
doaj   +1 more source

Affected Persons in Laboratory Exposures to Human Pathogens and Toxins in Canada, 2016–2024: A Sector‐Specific Analysis

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Exposures to human pathogens and toxins in licensed facilities in Canada have been monitored by a federal surveillance system since 2015, yet the affected persons (APs) in these incidents remain uncharacterized. This study comprehensively describes APs, highlighting sector‐specific patterns and trends over time.
Emily F. Tran, Christine Abalos, Antoinette N. Davis, Audrey Gauthier, Samuel Bonti‐Ankomah   +4 more
wiley   +1 more source