Results 81 to 90 of about 12,794 (224)
, 2010 Although proteinacious in nature, prions exist as strains with specific self-perpetuating biological properties. Prion strains are thought to be associated with different conformers of PrPSc, a disease-associated isoform of the host-encoded cellular ...
Gabriele Vaccari +34 more
core +1 more source
, 2012 In this article the development and parameterization of a quantitative assessment is described that estimates the amount of TSE infectivity that is present in a whole animal carcass (bovine spongiform encephalopathy [BSE] for cattle and classical ...
Adkin, A. +5 more
core +1 more source
Effects of post-translational modifications on prion protein aggregation and the propagation of scrapie-like characteristics in vitro [PDF]
, 2007 Prion diseases, or transmissible spongiform encephalopathies (TSEs) are typically characterised by CNS accumulation of PrPSc, an aberrant conformer of a normal cellular protein PrPC.
Oxley, David +9 more
core +1 more source
Veterinary Research, 2018 In animal prion diseases, including bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in cervids, and scrapie in sheep and goats, a disease-associated isoform of prion protein (PrPd) accumulates in the brains of affected animals ...
Kohtaro Miyazawa +5 more
doaj +1 more source
Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer +45 more
wiley +1 more source
, 2013 Wastewater from facilities processing livestock that may harbor transmissible spongiform encephalopathies (TSEs) infectivity is permitted under license for application to land where susceptible livestock may have access. Several previous risk assessments
Adkin, A. +2 more
core +1 more source
The Chemical Record, Volume 25, Issue 10, October 2025.This review explores aptamers as therapeutic oligonucleotides targeting neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's, with a focus on G‐quadruplex‐forming sequences. It discusses chemical modifications that enhance aptamer stability and function, alongside the use of clay nanoparticles, such as halloysite nanotubes ...
Valentina Arciuolo +9 more
wiley +1 more source
Retrospective surveillance of atypical scrapie in Japan
, 2008 Recently, atypical scrapie cases have increased mainly in genetically scrapie-resistant sheep in Europe. The characteristics of the abnormal isoform of prion protein (PrP^Sc) and its deposition pattern in the brain differ between atypical and classical ...
IMAMURA, Morikazu +17 more
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A Targeted Survey for Scrapie in Jos Plateau State, Nigeria [PDF]
, 2013 Scrapie, a disease of sheep and goats with a progressive course and fatal outcome, has not been identified in Nigeria. Anecdotal scrapie reports by livestock workers abound. Livestock diseases like scrapie form huddles in livestock economics of countries.
Seuberlich, Torsten +5 more
core +1 more source
Genes, Brain and Behavior, Volume 24, Issue 5, October 2025.Sex‐specific differential expression of the genes in the synaptic vesicle cycle pathway of the amygdala in response to stimuli. In the pathway network depiction, the edges connecting the nodes (genes) represent known molecular interactions. More intense red and blue hues indicate gene under‐expression and over‐expression in response to fasting relative
Sreelaya Bhamidi +5 more
wiley +1 more source