Results 81 to 90 of about 29,784 (268)
Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
Journal of Visualized Experiments, 2014 The diagnosis of scrapie, a transmissible spongiform encephalopathy (TSEs) of sheep and goats, is currently based on the detection of disease-associated prion protein by post mortem tests.
T. Konold, Laura J. Phelan
semanticscholar +1 more source
PLoS ONE, 2019 Scrapie is a fatal neurodegenerative disease of sheep and goats belonging to the group of Transmissible Spongiform Encephalopathy or prion diseases. The EU has adopted mandatory measures for scrapie surveillance to safeguard public and animal health ...
Henrik Zetterberg +8 more
doaj +1 more source
Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer +45 more
wiley +1 more source
The Chemical Record, Volume 25, Issue 10, October 2025.This review explores aptamers as therapeutic oligonucleotides targeting neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's, with a focus on G‐quadruplex‐forming sequences. It discusses chemical modifications that enhance aptamer stability and function, alongside the use of clay nanoparticles, such as halloysite nanotubes ...
Valentina Arciuolo +9 more
wiley +1 more source
Prion degradation pathways: Potential for therapeutic intervention [PDF]
, 2015 Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be
Goold, R, McKinnon, C, Tabrizi, SJ
core +1 more source
Genes, Brain and Behavior, Volume 24, Issue 5, October 2025.Sex‐specific differential expression of the genes in the synaptic vesicle cycle pathway of the amygdala in response to stimuli. In the pathway network depiction, the edges connecting the nodes (genes) represent known molecular interactions. More intense red and blue hues indicate gene under‐expression and over‐expression in response to fasting relative
Sreelaya Bhamidi +5 more
wiley +1 more source
Atypical/Nor98 scrapie infectivity in sheep peripheral tissues. [PDF]
PLoS Pathogens, 2011 Atypical/Nor98 scrapie was first identified in 1998 in Norway. It is now considered as a worldwide disease of small ruminants and currently represents a significant part of the detected transmissible spongiform encephalopathies (TSE) cases in Europe ...
Olivier Andréoletti +14 more
doaj +1 more source
Assignment of the Human and Mouse Prion Protein Genes to Homologous Chromosomes [PDF]
, 1986 Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles.
Blatt, Cila +13 more
core
The FASEB Journal, Volume 39, Issue 17, 15 September 2025.Knock‐in mice expressing PrP with a partial deletion of the C‐terminal signal sequence (KIBVPrP248) showed reduced PrPC expression and resistance to prion infection. The underlying mechanism is that the mutant PrP is aberrantly retained in the endoplasmic reticulum and eventually undergoes proteasomal degradation.
Miryeong Yoo +12 more
wiley +1 more source
Veterinary Research, 2018 In animal prion diseases, including bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in cervids, and scrapie in sheep and goats, a disease-associated isoform of prion protein (PrPd) accumulates in the brains of affected animals ...
Kohtaro Miyazawa +5 more
doaj +1 more source