Results 101 to 110 of about 26,346 (266)
Physics of Protein Aggregation in Normal and Accelerated Brain Aging
BioEssays, Volume 47, Issue 8, August 2025.Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay +9 more
wiley +1 more source
Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities
Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.ABSTRACT Primary dysautonomia is a complex and often fatal autonomic nervous system disease. This literature review consolidates information on dysautonomia across species. Electronic databases (PubMed, Google Scholar and the Equine Grass Sickness Fund website) were systematically searched for veterinary and human medical literature on the topic.
Callum N. Atkins +2 more
wiley +1 more source
IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease [PDF]
, 2019 Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD).
Dodel, Richard +10 more
core +1 more source
In Vivo Quantification of Creatine Kinase Kinetics in Mouse Brain Using 31P‐MRS at 7 T
NMR in Biomedicine, Volume 38, Issue 6, June 2025.We demonstrate the feasibility of using 31P‐MRS to quantify creatine kinase activity in the mouse brain on preclinical 7‐T scanners. A 20% drop in respiration increased the apparent forward rate constant by 36%, likely due to altered pH and mitochondrial ATP production.
Mohamed Tachrount +3 more
wiley +1 more source
Helices 2 and 3 are the initiation sites in the PrPc -> PrPsc transition
, 2012 It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes that the normal cellular form PrPC undergoes in the conversion process to a self-replicating ...
Chen, Jie, Thirumalai, Devarajan
core +1 more source
BMC Veterinary Research, 2020 Background Classical scrapie susceptibility in sheep has been linked to three polymorphisms at codon 136, 154, and 171 in the prion protein gene (PRNP) whereas atypical scrapie susceptibility is related to polymorphisms at codon 141.
Eden Yitna Teferedegn +2 more
doaj +1 more source
Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins [PDF]
, 2011 Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. The neurodegenerative diseases such as Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob diseases, Gerstmann-Str$\ddot{a}$ussler ...
Zhang, Jiapu
core +2 more sources
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]
, 2008 Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano +8 more
core +3 more sources
BMC Veterinary Research, 2010 Background Atypical scrapie was first identified in Norwegian sheep in 1998 and has subsequently been identified in many countries. Retrospective studies have identified cases predating the initial identification of this form of scrapie, and ...
Bellworthy Susan J +5 more
doaj +1 more source
Ankara Üniversitesi Veteriner Fakültesi Dergisi, 1964 Scrapie is a progressive disease of sheep characterised by nervoussymptoms and by a diffuse or focal degeneration of the grey matterof the subcortical centers along the neuroaxis of the central nervoussystem. The disease as far as we are aware is invariably fataL.The clinical symptoms in the shcep consist of incoordination ofgait, trembling and severe ...
openaire +3 more sources