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Editorial: Women in science - nuclear medicine 2024. [PDF]
Front Med (Lausanne)Gutfilen B, Ramirez-Fort MK.
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Pathogenesis, detection, and control of scrapie in sheep.
American Journal of Veterinary Research, 2020In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a prion (designated PrPSc). The normal cellular prion protein (PrPC) is encoded by an endogenous gene, PRNP, that is present in high concentrations within the ...
E. Cassmann, J. Greenlee
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Journal of Comparative Pathology and Therapeutics, 1950
Summary Scrapie occurring in certain Scottish sheep stocks is an infective disease caused by a filtrable virus of undetermined size. The disease is transmissable in series from sheep to sheep; in the present investigation nine successful passages have been made.
D R, WILSON, R D, ANDERSON, W, SMITH
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Summary Scrapie occurring in certain Scottish sheep stocks is an infective disease caused by a filtrable virus of undetermined size. The disease is transmissable in series from sheep to sheep; in the present investigation nine successful passages have been made.
D R, WILSON, R D, ANDERSON, W, SMITH
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Molecular Biotechnology, 1998
Scrapie and other transmissible spongiform encephalopathies (TSEs) are characterized by similar pathology, biochemistry and genetics. The PrP protein and its conversion to the disease-related isoform, PrPSC, are crucial for the development of all TSEs.
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Scrapie and other transmissible spongiform encephalopathies (TSEs) are characterized by similar pathology, biochemistry and genetics. The PrP protein and its conversion to the disease-related isoform, PrPSC, are crucial for the development of all TSEs.
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Scrapie associated fibrils in the diagnosis of scrapie in sheep
Veterinary Record, 1987Previous research has consistently demonstrated by electron microscopy the presence of scrapie associated fibrils in brain extracts prepared from mice and hamsters with clinical signs of experimental scrapie. In the present study similar fibrils were seen in all the brain extracts prepared from 11 Cheviot or Suffolk sheep with natural or experimental ...
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Revue Scientifique et Technique de l'OIE, 1992
A detailed review is presented of the history, geographical distribution, cause, epidemiology, clinical features, pathogenesis, pathology, diagnosis, prevention, control and economic effects of scrapie in sheep. Brief mention is made of the disease in goats and moufflon.
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A detailed review is presented of the history, geographical distribution, cause, epidemiology, clinical features, pathogenesis, pathology, diagnosis, prevention, control and economic effects of scrapie in sheep. Brief mention is made of the disease in goats and moufflon.
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British Veterinary Journal, 1991
Scrapie was first recorded in Cyprus in 1985 in two flocks of sheep and subsequently the disease was diagnosed in dairy goats kept in mixed flocks with affected sheep. By 1989 scrapie had been diagnosed in 23 flocks. Epidemiological data presented in the present study are essentially from clinicopathological investigations between 1985 and 1989.
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Scrapie was first recorded in Cyprus in 1985 in two flocks of sheep and subsequently the disease was diagnosed in dairy goats kept in mixed flocks with affected sheep. By 1989 scrapie had been diagnosed in 23 flocks. Epidemiological data presented in the present study are essentially from clinicopathological investigations between 1985 and 1989.
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British Medical Bulletin, 1993
There is no specific marker for scrapie infectivity, and therefore no means other than prolonged bioassay for estimating levels of infection in tissues. Our knowledge of replication dynamics depends on precise rodent models which have enabled us to determine how the disease spreads and in which cells it replicates.
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There is no specific marker for scrapie infectivity, and therefore no means other than prolonged bioassay for estimating levels of infection in tissues. Our knowledge of replication dynamics depends on precise rodent models which have enabled us to determine how the disease spreads and in which cells it replicates.
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