Results 171 to 180 of about 12,794 (224)
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Journal of Comparative Pathology and Therapeutics, 1950
Summary Scrapie occurring in certain Scottish sheep stocks is an infective disease caused by a filtrable virus of undetermined size. The disease is transmissable in series from sheep to sheep; in the present investigation nine successful passages have been made.
D R, WILSON, R D, ANDERSON, W, SMITH
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Summary Scrapie occurring in certain Scottish sheep stocks is an infective disease caused by a filtrable virus of undetermined size. The disease is transmissable in series from sheep to sheep; in the present investigation nine successful passages have been made.
D R, WILSON, R D, ANDERSON, W, SMITH
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Molecular Biotechnology, 1998
Scrapie and other transmissible spongiform encephalopathies (TSEs) are characterized by similar pathology, biochemistry and genetics. The PrP protein and its conversion to the disease-related isoform, PrPSC, are crucial for the development of all TSEs.
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Scrapie and other transmissible spongiform encephalopathies (TSEs) are characterized by similar pathology, biochemistry and genetics. The PrP protein and its conversion to the disease-related isoform, PrPSC, are crucial for the development of all TSEs.
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Scrapie associated fibrils in the diagnosis of scrapie in sheep
Veterinary Record, 1987Previous research has consistently demonstrated by electron microscopy the presence of scrapie associated fibrils in brain extracts prepared from mice and hamsters with clinical signs of experimental scrapie. In the present study similar fibrils were seen in all the brain extracts prepared from 11 Cheviot or Suffolk sheep with natural or experimental ...
P H, Gibson +4 more
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Revue Scientifique et Technique de l'OIE, 1992
A detailed review is presented of the history, geographical distribution, cause, epidemiology, clinical features, pathogenesis, pathology, diagnosis, prevention, control and economic effects of scrapie in sheep. Brief mention is made of the disease in goats and moufflon.
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A detailed review is presented of the history, geographical distribution, cause, epidemiology, clinical features, pathogenesis, pathology, diagnosis, prevention, control and economic effects of scrapie in sheep. Brief mention is made of the disease in goats and moufflon.
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British Veterinary Journal, 1991
Scrapie was first recorded in Cyprus in 1985 in two flocks of sheep and subsequently the disease was diagnosed in dairy goats kept in mixed flocks with affected sheep. By 1989 scrapie had been diagnosed in 23 flocks. Epidemiological data presented in the present study are essentially from clinicopathological investigations between 1985 and 1989.
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Scrapie was first recorded in Cyprus in 1985 in two flocks of sheep and subsequently the disease was diagnosed in dairy goats kept in mixed flocks with affected sheep. By 1989 scrapie had been diagnosed in 23 flocks. Epidemiological data presented in the present study are essentially from clinicopathological investigations between 1985 and 1989.
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British Medical Bulletin, 1993
There is no specific marker for scrapie infectivity, and therefore no means other than prolonged bioassay for estimating levels of infection in tissues. Our knowledge of replication dynamics depends on precise rodent models which have enabled us to determine how the disease spreads and in which cells it replicates.
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There is no specific marker for scrapie infectivity, and therefore no means other than prolonged bioassay for estimating levels of infection in tissues. Our knowledge of replication dynamics depends on precise rodent models which have enabled us to determine how the disease spreads and in which cells it replicates.
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New Zealand Veterinary Journal, 1977
Abstract Extract It will probably never be known why New Zealand sheep up to 1952 remained free from the particular slow virus disease called scrapie. Scrapie has occurred for many years in European countries from which many of our earlier sheep breeds were imported.
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Abstract Extract It will probably never be known why New Zealand sheep up to 1952 remained free from the particular slow virus disease called scrapie. Scrapie has occurred for many years in European countries from which many of our earlier sheep breeds were imported.
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, 2016 Scrapie is a neurodegenerative disease, caused by a prion, that affects sheep, and less frequently, goats. Infected animals do not usually become ill for years; however, the clinical signs are progressive and invariably fatal once they develop.
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Nature, 1972
THE nature of the scrapie agent1,2 is of considerable interest especially as to whether it is a virus in the strict sense, or some replicating agent devoid of nucleic acid3,4, or indeed whether scrapie disease represents a transmissible progressive biochemical transformation of cellular membranes5,6.
H K, Narang +3 more
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THE nature of the scrapie agent1,2 is of considerable interest especially as to whether it is a virus in the strict sense, or some replicating agent devoid of nucleic acid3,4, or indeed whether scrapie disease represents a transmissible progressive biochemical transformation of cellular membranes5,6.
H K, Narang +3 more
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The nature of the scrapie agent
Medical Hypotheses, 1986There now seems little doubt that the infective agent of scrapie cannot be accommodated within current concepts of virology/molecular biology. It is proposed: that the basic infective entity is a nucleic acid fragment (oligonucleotide) of some 40 bp coupled with specific (but host encoded) protein totalling approximately 10(5) daltons, a significant ...
D.H. Adams, null M.R.C. External Staff
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