Significant differences in incubation times in sheep infected with bovine spongiform encephalopathy result from variation at codon 141 in the PRNP gene [PDF]
, 2012 The susceptibility of sheep to prion infection is linked to variation in the PRNP gene, which encodes the prion protein. Common polymorphisms occur at codons 136, 154 and 171.
Blanco, A. R. A. +8 more
core +1 more source
Low-volume goat milk transmission of classical scrapie to lambs and goat kids. [PDF]
PLoS ONE, 2018 The risk of classical scrapie transmission in small ruminants is highest during the neonatal period with the placenta recognized as a significant source of infection.
Sally A Madsen-Bouterse +4 more
doaj +1 more source
Emerging infectious diseases: coping with uncertainty [PDF]
, 2009 The world’s scientific community must be in a state of constant readiness to address the threat posed by newly emerging infectious diseases. Whether the disease in question is SARS in humans or BSE in animals, scientists must be able to put into action ...
Cummings, L
core +1 more source
Atypical scrapie in sheep from a UK research flock which is free from classical scrapie
BMC Veterinary Research, 2009 Background In the wake of the epidemic of bovine spongiform encephalopathy the British government established a flock of sheep from which scrapie-free animals are supplied to laboratories for research.
Ortiz-Pelaez Angel +9 more
doaj +1 more source
Atypical scrapie isolates involve a uniform prion species with a complex molecular signature. [PDF]
PLoS ONE, 2011 The pathobiology of atypical scrapie, a prion disease affecting sheep and goats, is still poorly understood. In a previous study, we demonstrated that atypical scrapie affecting small ruminants in Switzerland differs in the neuroanatomical distribution ...
Dorothea R Götte +5 more
doaj +1 more source
Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (bse) and scrapie in Great Britain [PDF]
, 2017 Transmissible spongiform encephalopathies (TSEs) are an important public health concern. Since the emergence of bovine spongiform encephalopathy (BSE) during the 1980s and its link with human Creutzfeldt- Jakob disease, active surveillance has been a key
Arnold +16 more
core +3 more sources
Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission
Frontiers in Veterinary Science, 2015 Classical scrapie is an environmentally transmissible prion disease of sheep and goats. Prions can persist and remain potentially infectious in the environment for many years and thus pose a risk of infecting animals after re-stocking.
Timm eKonold +6 more
doaj +1 more source
VirusesChronic wasting disease (CWD), a transmissible spongiform encephalopathy that targets cervids, has become a significant threat to both free-ranging and captive populations of Canadian white-tailed deer.
William Pilot +5 more
doaj +1 more source
Atypical status of bovine spongiform encephalopathy in Poland: a molecular typing study [PDF]
, 2008 The aim of this study was to analyze molecular features of protease-resistant prion protein (PrPres) in Western blots of BSE cases diagnosed in Poland with respect to a possible atypical status.
Jacobs, J.G. +3 more
core +1 more source
Diversity in neuroanatomical distribution of abnormal prion protein in atypical scrapie.
PLoS Pathogens, 2007 Scrapie is a transmissible spongiform encephalopathy (TSE) in sheep and goats. In recent years, atypical scrapie cases were identified that differed from classical scrapie in the molecular characteristics of the disease-associated pathological prion ...
Alice Nentwig +7 more
doaj +1 more source