Results 71 to 80 of about 26,346 (266)
Scrapie-Associated Tubulofilamentous Particles in Scrapie Hamsters
Intervirology, 1992 Examination of thin sections from the cerebral cortex of scrapie-infected hamster brains revealed characteristic circular 26-30 nm diameter tubulofilamentous particles, identical to those previously described in both experimentally induced scrapie in mice, hamsters and natural scrapie of sheep, bovine spongiform encephalopathy and human Creutzfeldt ...
openaire +2 more sources
A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing
Advanced Science, Volume 12, Issue 41, November 6, 2025.This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang +17 more
wiley +1 more source
Genotyping and surveillance for scrapie in Finnish sheep
BMC Veterinary Research, 2012 Background The progression of scrapie is known to be influenced by the amino acid polymorphisms of the host prion protein (PrP) gene. There is no breeding programme for TSE resistance in sheep in Finland, but a scrapie control programme has been in place
Hautaniemi Maria +3 more
doaj +1 more source
PLoS Pathogens, 2023 Prion agents occur in strains that are encoded by the structure of the misfolded prion protein (PrPSc). Prion strains can influence disease phenotype and the potential for interspecies transmission.
Robyn D Kokemuller +4 more
doaj +1 more source
A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein [PDF]
, 2016 Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrPC) into PrPSc, a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals.
Biasini, Emiliano +16 more
core +2 more sources
Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie
Scientific Reports, 2021 Pigs are susceptible to infection with the classical bovine spongiform encephalopathy (C-BSE) agent following experimental inoculation, and PrPSc accumulation was detected in porcine tissues after the inoculation of certain scrapie and chronic wasting ...
Belén Marín +12 more
doaj +1 more source
Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer +45 more
wiley +1 more source
Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure [PDF]
, 2005 The accumulation of the scrapie agent in lymphoid tissues following inoculation via the skin is critical for efficient neuroinvasion, but how the agent is initially transported from the skin to the draining lymph node is not known. Langerhans cells (LCs)
Caughey B +10 more
core +2 more sources
The Chemical Record, Volume 25, Issue 10, October 2025.This review explores aptamers as therapeutic oligonucleotides targeting neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's, with a focus on G‐quadruplex‐forming sequences. It discusses chemical modifications that enhance aptamer stability and function, alongside the use of clay nanoparticles, such as halloysite nanotubes ...
Valentina Arciuolo +9 more
wiley +1 more source
PLoS ONE, 2020 Scrapie, a prion disease of sheep, is highly resistant to conventional deactivation. Numerous methods to deactivate scrapie have been tested in laboratory animal models, and adequate autoclave treatment can reduce or remove the infectivity of some ...
Eric D Cassmann +2 more
doaj +1 more source