Results 81 to 90 of about 26,346 (266)

Scrapie Resistance Gene Identification using Optimized Taqman Test qPCR Method in Sheep on the Territory of the Republic of Serbia

open access: yesActa Veterinaria, 2021
Scrapie is an infectious neurodegenerative disease affecting the central nervous system of sheep and goats that belongs to transmissible spongiform encephalopathies.
Nešić Slađan   +4 more
doaj   +1 more source

Metabolic and Inflammatory Stimuli Impact Vascular Circulation and Cell Proliferation Processes in the Amygdala

open access: yesGenes, Brain and Behavior, Volume 24, Issue 5, October 2025.
Sex‐specific differential expression of the genes in the synaptic vesicle cycle pathway of the amygdala in response to stimuli. In the pathway network depiction, the edges connecting the nodes (genes) represent known molecular interactions. More intense red and blue hues indicate gene under‐expression and over‐expression in response to fasting relative
Sreelaya Bhamidi   +5 more
wiley   +1 more source

High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrP in vivo [PDF]

open access: yes, 2007
Rona Barron - ORCID: 0000-0003-4512-9177 https://orcid.org/0000-0003-4512-9177Diagnosis of transmissible spongiform encephalopathy (TSE) disease in humans and ruminants relies on the detection in post-mortem brain tissue of the protease-resistant form of
Barron, R. M.   +6 more
core   +1 more source

Partial Deletion of the Carboxyl‐Terminal Signal Sequence of the Cellular Prion Protein Alters Protein Expression via Endoplasmic Reticulum–Associated Degradation

open access: yesThe FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Knock‐in mice expressing PrP with a partial deletion of the C‐terminal signal sequence (KIBVPrP248) showed reduced PrPC expression and resistance to prion infection. The underlying mechanism is that the mutant PrP is aberrantly retained in the endoplasmic reticulum and eventually undergoes proteasomal degradation.
Miryeong Yoo   +12 more
wiley   +1 more source

Classic Scrapie in Sheep with the ARR/ARR Prion Genotype in Germany and France

open access: yesEmerging Infectious Diseases, 2007
In the past, natural scrapie and bovine spongiform encephalopathy (BSE) infections have essentially not been diagnosed in sheep homozygous for the A136R154R171 haplotype of the prion protein.
Martin H. Groschup   +12 more
doaj   +1 more source

Lambs with scrapie susceptible genotypes have higher postnatal survival. [PDF]

open access: yesPLoS ONE, 2007
BACKGROUND: Prion protein (PrP) alleles associated with scrapie susceptibility persist in many sheep populations even with high frequencies despite centuries of selection against them.
Rami M Sawalha   +3 more
doaj   +1 more source

Japanese Scrapie Cases

open access: yesJapanese Journal of Infectious Diseases, 2000
Worldwide attention has been given to scrapie, because bovine spongiform encephalopathy (BSE) could be experimentally transmitted to sheep. This ovine form of BSE was clinically identical to scrapie. In Japanese scrapie cases, a majority of the diseased sheep were from Suffolk, while 8 cases were from Corriedale.
T, Onodera, K, Saeki
openaire   +2 more sources

Factors influencing Wisconsin deer hunter participation in voluntary CWD testing

open access: yesThe Journal of Wildlife Management, Volume 89, Issue 7, September 2025.
Hunter participation in testing harvested white‐tailed deer for chronic wasting disease (CWD) is a critical wildlife disease surveillance strategy. We present the results of a binary logistic model to quantify the effects of CWD status of the county of harvest, perceptions of CWD risk, trust in information provided by the management agency, and belief ...
Ben Beardmore   +3 more
wiley   +1 more source

Neurofilaments in blood is a new promising preclinical biomarker for the screening of natural scrapie in sheep.

open access: yesPLoS ONE, 2019
Scrapie is a fatal neurodegenerative disease of sheep and goats belonging to the group of Transmissible Spongiform Encephalopathy or prion diseases. The EU has adopted mandatory measures for scrapie surveillance to safeguard public and animal health ...
Henrik Zetterberg   +8 more
doaj   +1 more source

The Molecular Pathology of Prion Diseases [PDF]

open access: yes, 2004
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of invariably fatal neurodegenerative disorders. Uniquely, they may present as sporadic, inherited, or infectious forms, all of which involve conversion of the normal ...
Herms, Jochen   +2 more
core  

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