Results 81 to 90 of about 5,354,916 (300)
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
A study on the role of sea ice in the nitrous oxide cycle in the Prydz Bay, Antarctica
Frontiers in Marine ScienceN2O is one of the most important greenhouse gases and ozone depletor, which was a matter of more and more concerned. The Southern Ocean was considered as one of the most important N2O source and was believed to account for ~1/4 of oceanic budget. However,
Man Wu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Gypsum and hydrohalite dynamics in sea ice brines [PDF]
Geochimica et Cosmochimica Acta, 2017 Abstract Mineral authigenesis from their dissolved sea salt matrix is an emergent feature of sea ice brines, fuelled by dramatic equilibrium solubility changes in the large sub-zero temperature range of this cryospheric system on the surface of high latitude oceans.
Benjamin M. Butler +3 more
openaire +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Using Sea-Level Data to Constrain the Contribution of the Greenland Ice Sheet to Contemporary and Recent Sea-Level Change [PDF]
, 2010 Due to the potentially wide-reaching impacts on climate and sea-level change of a declining Greenland Ice Sheet (GrIS), the mass balance of the past decade has caused concern that the ice sheet is reacting to increased temperatures of the industrial era ...
Wake, Leanne Mary, WAKE, LEANNE,MARY
core
Journal of Climate, 2015 Abstract The study analyzes the sensitivity and memory of the Southern Hemisphere coupled climate system to increased Antarctic sea ice (ASI), taking into account the persistence of the sea ice maxima in the current climate. The mechanisms involved in restoring the climate balance under two sets of experiments, which differ in regard to ...
Claudia K. Parise +3 more
openaire +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Microbial Loop Dynamics in Antarctic Sea-Ice
, 2009 Sea-ice is a predominant feature of polar oceans and exerts a unique influence on marine ecosystems. The annual circumpolar expansion of sea-ice around Antarctica provides a stable platform for the in situ colonisation and growth of a diverse assemblage ...
Martin, Andrew Robert (11640262) +2 more
core +1 more source
An assessment of key model parametric uncertainties in projections of Greenland Ice Sheet behavior [PDF]
, 2012 Lack of knowledge about the values of ice sheet model input parameters introduces substantial uncertainty into projections of Greenland Ice Sheet contributions to future sea level rise.
Stone, Emma J. +17 more
core +2 more sources