Results 91 to 100 of about 5,134,596 (300)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sea Ice Dynamics in Foxe Basin: Formation of a Thick Dirty Seasonal Ice Cover along a Proposed Year-Round Shipping Route

Arctic Science
Foxe Basin is a shallow inland sea in the Canadian Arctic that has strong tidal dynamics and is covered by a notoriously deformed and dirty sea ice cover for 9 months a year.
David Babb, Sergei Kirillov, Ryan Galley, Jens Ehn   +3 more
doaj   +1 more source

Recent trends in melting conditions on the Antarctic Peninsula and their implications for ice-sheet mass balance and sea level [PDF]

, 2006
Long-term records from meteorological stations on the Antarctic Peninsula show strong rising trends in the annual duration of melting conditions. In each case, the trend is statistically significant and represents a major increase in the potential for ...
Dowdeswell, J.A., Bassford, R. P., Glazovsky, A.F., Glazovsky, A. F., Siegert, M. J,, Macheret, Y.Y., Macheret, Y. Y., Vaughan, David G., J. A. Dowdeswell, David G. Vaughan, A. F. Glazovsky, Oerlemans, J., R. P. Bassford, Bassford, R.P., Y. Y. Macheret, M. J. Siegert, Siegert, M. J., Dowdeswell, J. A., Siegert, M.J., J. Oerlemans, Hoch, Günter, Dowling, Carolyn, Vaughn, Bruce H., Olofsson, Johan,, Körner, Christian, Lyons, W. Berry, Gooseff, Michael N., Fountain, Andrew G., McKnight, Diane M.   +28 more
core   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The impact of sea ice melt on the evolution of surface pCO2 in a polar ocean basin

Frontiers in Marine Science
The strong CO2 sink in Arctic Ocean plays a significant role in the global carbon budget. As a high-latitude oceanic ecosystem, the features of sea surface pCO2 and air-sea CO2 flux are significantly influenced by sea ice melt; however, our understanding
Wei Yang, Yu Zhao, Yingxu Wu, Zijie Chen, Xiang Gao, Hongmei Lin, Zhangxian Ouyang, Weijun Cai, Liqi Chen, Di Qi   +9 more
doaj   +1 more source

Sea ice friction and Arctic sea ice dynamics

, 2010
A series of double-shear experiments were undertaken in the Environmental Test Basin at the Hamburgische Shiffbau-Versuchsanstalt (HSVA) in Hamburg. The aim of these experiments was to improve understanding of transient behaviour in sea ice friction. To this end we have fitted our experimental results to a rate- and state- dependent model of friction ...
Lishman, Ben, Sammonds, Peter, Feltham, Danny, Wilchinsky, Alex   +3 more
openaire   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Microbial Loop Dynamics in Antarctic Sea-Ice [PDF]

, 2021
<p>Sea-ice is a predominant feature of polar oceans and exerts a unique influence on marine ecosystems. The annual circumpolar expansion of sea-ice around Antarctica provides a stable platform for the in situ colonisation and growth of a diverse assemblage of microbes that are integral to the energy base of the Southern Ocean. An active microbial
openaire   +1 more source