Results 91 to 100 of about 5,354,916 (300)
A large-scale high-resolution numerical model for sea-ice fragmentation dynamics [PDF]
The CryosphereForecasts of sea-ice motion and fragmentation are of vital importance for all human interactions with sea ice, ranging from those involving indigenous hunters to shipping in polar regions.
J. Åström +5 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Calving rates at tidewater glaciers vary strongly with ocean temperature [PDF]
, 2015 TerraSAR-X data were provided by DLR (project OCE1503), and funded by the Conoco Phillips-Lundin Northern Area Program through the CRIOS project (Calving Rates and Impact on Sea level). A.L. and S.B.
Luckman, Adrian +14 more
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Late Quaternary ice-ocean interactions in central West Greenland [PDF]
, 2011 A greater knowledge of the interactions between the Greenland Ice Sheet and climate is critical to understanding the possible impacts of future global warming, including ice sheet contribution to global sea-level rise and perturbations to ocean ...
MCCARTHY, DAVID,JOHN +1 more
core
Numerical study of sea ice dynamics and wave-ice interactions in the marginal ice zone
, 2021 The Marginal Ice Zone (MIZ) is a highly dynamic region between the open ocean and the inner ice pack. The ice over this region is subjected to waves, introducing new forces but also changing the ice from a cohesive material to a mobile collection of ...
Auclair, Jean-Pierre
core
Arctic ScienceFoxe Basin is a shallow inland sea in the Canadian Arctic that has strong tidal dynamics and is covered by a notoriously deformed and dirty sea ice cover for 9 months a year.
D.G. Babb +3 more
doaj +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Barents Sea ice cover reflects Atlantic inflow [PDF]
, 2011 The recent Arctic winter sea-ice retreat is most pronounced in the Barents Sea. Using available observations of the Atlantic inflow to the Barents Sea and results from a regional ice-ocean model we assess the role of inflowing heat anomalies on sea-ice ...
Skagseth, Øystein +3 more
core
Sea ice friction and Arctic sea ice dynamics
, 2010 A series of double-shear experiments were undertaken in the Environmental Test Basin at the Hamburgische Shiffbau-Versuchsanstalt (HSVA) in Hamburg. The aim of these experiments was to improve understanding of transient behaviour in sea ice friction. To this end we have fitted our experimental results to a rate- and state- dependent model of friction ...
Lishman, Ben +3 more
openaire +1 more source