Results 101 to 110 of about 136,579 (306)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Estimation of Arctic Sea Ice Thickness Using HY-2B Altimeter Data

Remote Sensing
Sea ice thickness is an important component of the Arctic environment, bearing crucial significance in investigations pertaining to global climate and environmental changes.
Chunyu Pang, Lele Li, Lili Zhan, Haihua Chen, Yingni Shi   +4 more
doaj   +1 more source

Present State and Prospects of Ice Sheet and Glacier Modelling [PDF]

, 2018
Since the late 1970s, numerical modelling has become established as an important technique for the understanding of ice sheet and glacier dynamics, and several models have been developed over the years.
Abe-Ouchi, Ayako, Blatter, Heinz, Greve, Ralf   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Potential climatic transitions with profound impact on Europe [PDF]

, 2011
We discuss potential transitions of six climatic subsystems with large-scale impact on Europe, sometimes denoted as tipping elements. These are the ice sheets on Greenland and West Antarctica, the Atlantic thermohaline circulation, Arctic sea ice, Alpine
A Born, A Ganachaud, A Ganopolski, A Hu, A Jones, A Laurian, A Levermann, A Levermann, A Levermann, A Levermann, A Schmittner, A Winguth, AA Scaife, Anders Levermann, Andrey Ganopolski, B Dickson, B Schaefli, B Zwierl, BJ Soden, BN Goswami, C Deser, C Haas, C Harris, C Schnadt, C Schoof, C Stick, C Vincent, CAPE-Last Interglaicial Project Members, CL Parkinson, D Farinotti, D Notz, D Pollard, D Stammer, DA Lashof, DA Rothrock, DB Kirk-Davidoff, DG Vaughan, Dirk Notz, DK Perovich, DM Holland, DM Lawrence, DT Shindell, DWJ Thompson, E Kriegler, E Meur Le, E Rignot, E Rignot, E Rignot, EJ Rignot, F Paul, F Paul, G Cogley, G Jouvet, G Kaser, G Manney, G Manney, G Manney, GA Meehl, GJ Oldenborgh van, H Goosse, H Hátún, HD Pritchard, HJ Schellnhuber, I Auer, I Eisenmann, I Joughin, I Joughin, I Velicogna, J Maslanik, J Noetzli, J Oerlemans, J Oerlemans, J Oerlemans, J Ridley, J Ridley, J Stroeve, J Weertman, J Yin, J Yin, J Zhang, JA Church, JC Comiso, JE Kay, JF McManus, JH Jungclaus, JL Bamber, JL Chen, JM Gregory, JM Gregory, Jonathan L. Bamber, JP Wilkinson, JR Miller, JT Overpeck, JX Mitrovica, K Eckhardt, K Zickfeld, KH Rosenlof, Kirstin Krüger, LC Sime, LH Smedsrud, M Beniston, M Dameris, M Hoelzle, M Hofmann, M Honda, M Huss, M Huss, M Huss, M Ogi, M Rex, M Rex, M Scheffer, M Stendel, M Vellinga, M Vellinga, M Wang, M Winton, M Winton, M Zemp, M Zemp, Matthias Huss, MF Meier, MM Holland, Neil R. P. Harris, NP Harris, NW Arnell, O Solomina, P Huybrechts, P Wadhams, P Wadhams, P Wadhams, Peter Wadhams, PM Forster, PU Clark, R Hock, R Lindsay, RE Kopp, RJ Braithwaite, RJ Stouffer, Ronald W. Lindsay, RP Scherer, S Amstrup, S Gruber, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Solomon, S Solomon, S Tegtmeier, S Tietsche, SJ Evans, SJ Oltmans, SL Weber, SL Weber, SS Drijfhout, Susanne Weber, Sybren Drijfhout, T Hattermann, T Kuhlbrodt, T Naish, T Toniazzo, Timothy M. Lenton, TM Lenton, V Petoukhov, VM Kattsov, W Haeberli, W Haeberli, W Weijer, Winfried Haeberli, WJ Randel, WT Pfeffer, Y Wang, ZW Kundzewicz   +174 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

State-of-the-art in studies of glacial isostatic adjustment for the British Isles: a literature review [PDF]

, 2016
Understanding the effects of glacial isostatic adjustment (GIA) of the British Isles is essential for the assessment of past and future sea-level trends.
Alistair Rennie, Arıkan, Bekaert, Bingley, Bähr, Davenport, Elizabeth J Petrie, Firth, Firth, Firth, Jardine, Jim Hansom, Julia Stockamp, Kaneko, Lambeck, Li, Li, Paul Bishop, Peltier, Plag, Ringrose, Samsonov, Shennan, Shennan, Shennan, Shennan, Sissons, Sissons, Sissons, Smith, Smith, Smith, Tong, Van de Plassche, Wang, Woodroffe, Zhenhong Li   +36 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source