Results 111 to 120 of about 878,327 (287)

Million years of Greenland Ice Sheet history recorded in ocean sediments [PDF]

open access: yes, 2011
Geological records from Tertiary and Quaternary terrestrial and oceanic sections have documented the presence of ice caps and sea ice covers both in the Southern and the Northern hemispheres since Eocene times, approximately since 45 Ma.
Jessen, Catherine   +6 more
core  

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

open access: yesAdvanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo   +8 more
wiley   +1 more source

Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats

open access: yesAdvanced Biology, EarlyView.
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang   +8 more
wiley   +1 more source

Optimized Cell‐Based Platform for Platelet‐Free Detection of Heparin‐Induced Thrombocytopenia Antibodies

open access: yesAdvanced Biology, EarlyView.
This study optimized a cell‐based ELISA for HIT antibody detection using PF4‐coated breast cancer cells (MDA‐MB‐231). Enhanced binding was observed at 50 mM NaCl and 4% paraformaldehyde fixation. Live MDA‐MB‐231 and HCT‐116 cells demontrated superior sensitivity and specificity, providing a promising platelet‐free alternative for clinical HIT diagnosis.
Li‐Yu Chen   +4 more
wiley   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Sea ice/climate studies [PDF]

open access: yes
The objectives were to determine and analyze the annual cycle of sea ice extents in the Arctic Ocean and peripheral seas and bays over the period 1973 to 1986, looking in particular for any long term trends; to examine the relationship between local sea ...
Parkinson, C. L.
core   +1 more source

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