Results 111 to 120 of about 902,814 (336)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Seasonal Arctic Sea Ice Prediction Using a Newly Developed Fully Coupled Regional Model With the Assimilation of Satellite Sea Ice Observations

Journal of Advances in Modeling Earth Systems, 2020
To increase our capability to predict Arctic sea ice and climate, we have developed a coupled atmosphere‐sea ice‐ocean model configured for the pan‐Arctic with sufficient flexibility.
Chao‐Yuan Yang, Jiping Liu, Shiming Xu
doaj   +1 more source

Southern Ocean warming: Increase in basal melting and grounded ice loss [PDF]

, 2013
We apply a global finite element sea ice/ice shelf/ocean model (FESOM) to the Antarctic marginal seas to analyze projections of ice shelf basal melting in a warmer climate.
Determann, Jürgen, Hellmer, Hartmut, Timmermann, Ralph   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Corresponding Volumes, etc., of Ice and Sea-Water [PDF]

, 1887
W. A. Ashe
openalex   +3 more sources

Capacity of a set of CMIP6 models to simulate Arctic sea ice drift

Annals of Glaciology
Evaluating CMIP6 model performance helps to improve the prediction of future changes in Arctic sea ice. We analyze the seasonal cycles, distribution, and evolution of sea ice in different regions from 1979 to 2014.
Xinfang Zhang, Jari Haapala, Petteri Uotila   +2 more
doaj   +1 more source

Expedition 302 geophysics: integrating past data with new results [PDF]

, 2006
In preparation for IODP Expedition 302, Arctic Coring Expedition (ACEX), a site survey database comprising geophysical and geological data from the Lomonosov Ridge was compiled.
Backman, J., Brinkhuis, H., Clemens, S., Cronin, T., Dickens, G.R., Eynaud, F., Floden, T., Gattacceca, J., Jakobsson, M., Jakobsson, M., Jordan, R.W., Kaminski, M., King, J., Koç, N., Martinez, N.C., Matthiessen, J., McInroy, D., Moore Jr., T.C., Moran, K., O'Regan, M., Onodera, J., Pälike, H., Rea, B., Rio, D., Sakamoto, T., Smith, D.C., St. John, K.E.K., Stein, R., Suto, I., Suzuki, N., Takahashi, K., Watanabe, M., Yamamoto, M.   +32 more
core   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Data on Physical Properties of Sea Ice in the Northern Barents Sea and Adjacent Arctic Basin From the Nansen Legacy Project

Geoscience Data Journal
Recent decline of sea ice in the Barents Sea represents a clear manifestation of the ongoing Arctic warming. This study presents a compilation of data sets on sea ice physics acquired during 2018–2022 during Nansen Legacy—a Norwegian multidisciplinary ...
Dmitry V. Divine, Adam Steer, Mats A. Granskog, Sebastian Gerland, Øyvind Foss, Anca Cristea, Polona Itkin, Malin Johansson, Emily Down, Agneta Fransson   +9 more
doaj   +1 more source