Results 91 to 100 of about 403,562 (281)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A twenty-first century structural change in Antarctica’s sea ice system
Communications Earth & EnvironmentFrom 1979 to 2016, total Antarctic sea ice extent experienced a positive trend with record winter maxima in 2012 and 2014. Record summer minima followed within the period 2017-2024, raising the possibility that the Antarctic sea ice system might be ...
Marilyn N. Raphael +4 more
doaj +1 more source
Million years of Greenland Ice Sheet history recorded in ocean sediments [PDF]
, 2011 Geological records from Tertiary and Quaternary terrestrial and oceanic sections have documented the presence of ice caps and sea ice covers both in the Southern and the Northern hemispheres since Eocene times, approximately since 45 Ma.
Jessen, Catherine +6 more
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The impact of early Holocene Arctic Shelf flooding on climate in an atmosphere–ocean–sea–ice model [PDF]
, 2013 Glacial terminations are characterized by a strong rise in sea level related to melting ice sheets. This rise in sea level is not uniform all over the world, because regional effects (uplift and subsidence of coastal zones) are superimposed on global ...
Blaschek, M., Renssen, H.
core +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Environmental Research Letters, 2015 The rapid change in Arctic sea ice in recent decades has led to a rising demand for seasonal sea ice prediction. A recent modeling study that employed a prognostic melt pond model in a stand-alone sea ice model found that September Arctic sea ice extent ...
Jiping Liu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Sea ice trends in climate models only accurate in runs with biased global warming
, 2017 Observations indicate that the Arctic sea ice cover is rapidly retreating while the Antarctic sea ice cover is steadily expanding. State-of-the-art climate models, by contrast, typically simulate a moderate decrease in both the Arctic and Antarctic sea ...
Eisenman, Ian, Rosenblum, Erica
core +1 more source